Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spliceosome RNA helicase DDX39B homolog

Gene

hel-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for mRNA export out of the nucleus. May play a role in spliceosome assembly.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 92ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • RNA binding Source: UniProtKB-KW
  • transcription factor binding Source: WormBase

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central
  • determination of adult lifespan Source: WormBase
  • mRNA export from nucleus Source: GO_Central
  • mRNA splicing, via spliceosome Source: GO_Central
  • positive regulation of gene expression Source: WormBase
  • RNA secondary structure unwinding Source: GO_Central

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-109688. Cleavage of Growing Transcript in the Termination Region.
R-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-CEL-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome RNA helicase DDX39B homolog (EC:3.6.4.13)
Alternative name(s):
DEAD box protein UAP56
Gene namesi
Name:hel-1
ORF Names:C26D10.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC26D10.2a; CE03025; WBGene00001840; hel-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleolus Source: GO_Central
  • nucleus Source: WormBase
  • spliceosomal complex Source: GO_Central
  • transcription factor complex Source: WormBase

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550791 – 425Spliceosome RNA helicase DDX39B homologAdd BLAST425

Proteomic databases

EPDiQ18212.
PaxDbiQ18212.
PeptideAtlasiQ18212.
PRIDEiQ18212.

PTM databases

iPTMnetiQ18212.

Expressioni

Gene expression databases

BgeeiWBGene00001840.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

IntActiQ18212. 8 interactors.
STRINGi6239.C26D10.2a.2.

Structurei

3D structure databases

ProteinModelPortaliQ18212.
SMRiQ18212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 245Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST174
Domaini257 – 418Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 69Q motifAdd BLAST29
Motifi192 – 195DECD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0329. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00830000128348.
InParanoidiQ18212.
OMAiIICQAKS.
OrthoDBiEOG091G0H5W.
PhylomeDBiQ18212.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEQLLDYE EEQEEIQDKQ PEVGGGDARK TKGTYASIHS SGFRDFLLKP
60 70 80 90 100
EILRAIGDCG FEHPSEVQHE CIPQAILGMD VVCQAKSGMG KTAVFVITTL
110 120 130 140 150
QQLEPVDGEV SVVCMCHTRE LAFQISKEYE RFSKYLPGVK VAVFFGGMAI
160 170 180 190 200
KKDEERLAND CPHIVVGTPG RMLALARSGK LKLDKVKYFV LDECDKMIGD
210 220 230 240 250
ADMRRDVQEI VKMTPQQKQV MMFSATLPKE LRTVCKRFMQ DPMEVYVDDE
260 270 280 290 300
AKLTLHGLQQ HYVKLKEAEK NRRLLNLLDA LEFNQVVIFV KAVKRCEALH
310 320 330 340 350
QLLTEQNFPS IAIHRQMAQE ERLSRYQAFK DFQKRILVAT DLFGRGMDIE
360 370 380 390 400
RVNIVFNYDM PEDSDSYLHR VARAGRFGTK GLAITFVSDE NDAKTLNSVQ
410 420
DRFDISITEL PEKIDVSTYI EGRTN
Length:425
Mass (Da):48,493
Last modified:November 1, 1996 - v1
Checksum:i7D6041E38AC3A44F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211 – 217Missing in AAB65852 (Ref. 2) Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54327 Genomic DNA. Translation: CAA91120.1.
U08102 mRNA. Translation: AAB65852.1.
PIRiT19484.
RefSeqiNP_001021985.1. NM_001026814.3.
UniGeneiCel.23307.

Genome annotation databases

EnsemblMetazoaiC26D10.2a; C26D10.2a; WBGene00001840.
GeneIDi174333.
KEGGicel:CELE_C26D10.2.
UCSCiC26D10.2a. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiDX39B_CAEEL
AccessioniPrimary (citable) accession number: Q18212
Secondary accession number(s): Q17323
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families