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Protein

Regulator of chromosome condensation

Gene

ran-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key component of the Ran GTPase system, which comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • embryo development ending in birth or egg hatching Source: WormBase
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of chromosome condensation
Alternative name(s):
Cell cycle regulatory protein
RCC1 homolog
Gene namesi
Name:ran-3
ORF Names:C26D10.1
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC26D10.1; CE03024; WBGene00004304; ran-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Regulator of chromosome condensationPRO_0000206632Add
BLAST

Proteomic databases

EPDiQ18211.
PaxDbiQ18211.

PTM databases

iPTMnetiQ18211.

Interactioni

Protein-protein interaction databases

IntActiQ18211. 1 interaction.
STRINGi6239.C26D10.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ18211.
SMRiQ18211. Positions 154-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati263 – 31856RCC1 1CuratedAdd
BLAST
Repeati388 – 45265RCC1 2CuratedAdd
BLAST
Repeati511 – 56858RCC1 3CuratedAdd
BLAST

Sequence similaritiesi

Contains 3 RCC1 repeats.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00840000129719.
HOGENOMiHOG000016067.
InParanoidiQ18211.
OMAiPTRIVNT.
PhylomeDBiQ18211.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAEQRMDT SEVELPNDNV NEQGNKTPRA DQPESSASGA RNHGEDEEVT
60 70 80 90 100
EQVELAAMET EASDSIVDNV PKTPRRAGRP KKLPSTSTAA AESAVTPGKR
110 120 130 140 150
GRKRKGSESV NTTINSTMNS TLNEPKTPGR KQAKLVAPLL TYDLFAPSII
160 170 180 190 200
GDRVLSCGEG EALGHPGRTT TKKPRKVDIF EEEGLKPLQA VAGGVHSAVL
210 220 230 240 250
TSEGEVYMCG INEKGTVPAE GVEKEGSTDE FAKVKFEEDI EKEGKIVMLA
260 270 280 290 300
AGASFTAALT DQGSVIAWGN LRNSNGNVDV HPLLHKMQEA PVVIVHQAKR
310 320 330 340 350
KIVKIAAGEN HLVMLDEKGC LLTFGDGEMG QLGRSSRTKT IRSKYMCDES
360 370 380 390 400
GDHLLVPLRF KHKGKFFDVV AKNVFASGFW TIVHGEDGKY YAFGLNNYAQ
410 420 430 440 450
LGIKVDEADV GQDGQDNREL RVFLPAEAPA FGAERTFVNI EGVQHVVILG
460 470 480 490 500
SDGKVFAMGK NTDNALGLGN WTGKDDQQHW LYDTIQEIEF DSKIVGVSAK
510 520 530 540 550
LATSIAWSED GTAYAWGFDT TGQLGLGLKD EDEKMVSKPE EISSAHLDGY
560
SIIGASISDQ HTLIIAKKN
Length:569
Mass (Da):61,485
Last modified:November 1, 1996 - v1
Checksum:iED487D2CAA45AFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54327 Genomic DNA. Translation: CAA91119.1.
PIRiT19483.
RefSeqiNP_495753.1. NM_063352.4.
UniGeneiCel.7393.

Genome annotation databases

EnsemblMetazoaiC26D10.1; C26D10.1; WBGene00004304.
GeneIDi174332.
KEGGicel:CELE_C26D10.1.
UCSCiC26D10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54327 Genomic DNA. Translation: CAA91119.1.
PIRiT19483.
RefSeqiNP_495753.1. NM_063352.4.
UniGeneiCel.7393.

3D structure databases

ProteinModelPortaliQ18211.
SMRiQ18211. Positions 154-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ18211. 1 interaction.
STRINGi6239.C26D10.1.1.

PTM databases

iPTMnetiQ18211.

Proteomic databases

EPDiQ18211.
PaxDbiQ18211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC26D10.1; C26D10.1; WBGene00004304.
GeneIDi174332.
KEGGicel:CELE_C26D10.1.
UCSCiC26D10.1. c. elegans.

Organism-specific databases

CTDi174332.
WormBaseiC26D10.1; CE03024; WBGene00004304; ran-3.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00840000129719.
HOGENOMiHOG000016067.
InParanoidiQ18211.
OMAiPTRIVNT.
PhylomeDBiQ18211.

Miscellaneous databases

PROiQ18211.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo."
    Bamba C., Bobinnec Y., Fukuda M., Nishida E.
    Curr. Biol. 12:503-507(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRCC1_CAEEL
AccessioniPrimary (citable) accession number: Q18211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Loss of ran-3 causes low levels of chromosomes to misalign on the metaphase plate and segregate incorrectly in early embryonic cell divisions.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.