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Protein

Regulator of chromosome condensation

Gene

ran-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Key component of the Ran GTPase system, which comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.1 Publication

Miscellaneous

Loss of ran-3 causes low levels of chromosomes to misalign on the metaphase plate and segregate incorrectly in early embryonic cell divisions.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • embryo development ending in birth or egg hatching Source: WormBase

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of chromosome condensation
Alternative name(s):
Cell cycle regulatory protein
RCC1 homolog
Gene namesi
Name:ran-3
ORF Names:C26D10.1
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC26D10.1 ; CE03024 ; WBGene00004304 ; ran-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066321 – 569Regulator of chromosome condensationAdd BLAST569

Proteomic databases

EPDiQ18211
PaxDbiQ18211
PeptideAtlasiQ18211
PRIDEiQ18211

PTM databases

iPTMnetiQ18211

Expressioni

Gene expression databases

BgeeiWBGene00004304

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ18211, 1 interactor
STRINGi6239.C26D10.1.1

Structurei

3D structure databases

ProteinModelPortaliQ18211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati263 – 318RCC1 1CuratedAdd BLAST56
Repeati388 – 452RCC1 2CuratedAdd BLAST65
Repeati511 – 568RCC1 3CuratedAdd BLAST58

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144029
HOGENOMiHOG000016067
InParanoidiQ18211
KOiK11493
OMAiWGFSSNY
OrthoDBiEOG091G05E6
PhylomeDBiQ18211

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00415 RCC1, 1 hit
PRINTSiPR00633 RCCNDNSATION
SUPFAMiSSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 3 hits

Sequencei

Sequence statusi: Complete.

Q18211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAEQRMDT SEVELPNDNV NEQGNKTPRA DQPESSASGA RNHGEDEEVT
60 70 80 90 100
EQVELAAMET EASDSIVDNV PKTPRRAGRP KKLPSTSTAA AESAVTPGKR
110 120 130 140 150
GRKRKGSESV NTTINSTMNS TLNEPKTPGR KQAKLVAPLL TYDLFAPSII
160 170 180 190 200
GDRVLSCGEG EALGHPGRTT TKKPRKVDIF EEEGLKPLQA VAGGVHSAVL
210 220 230 240 250
TSEGEVYMCG INEKGTVPAE GVEKEGSTDE FAKVKFEEDI EKEGKIVMLA
260 270 280 290 300
AGASFTAALT DQGSVIAWGN LRNSNGNVDV HPLLHKMQEA PVVIVHQAKR
310 320 330 340 350
KIVKIAAGEN HLVMLDEKGC LLTFGDGEMG QLGRSSRTKT IRSKYMCDES
360 370 380 390 400
GDHLLVPLRF KHKGKFFDVV AKNVFASGFW TIVHGEDGKY YAFGLNNYAQ
410 420 430 440 450
LGIKVDEADV GQDGQDNREL RVFLPAEAPA FGAERTFVNI EGVQHVVILG
460 470 480 490 500
SDGKVFAMGK NTDNALGLGN WTGKDDQQHW LYDTIQEIEF DSKIVGVSAK
510 520 530 540 550
LATSIAWSED GTAYAWGFDT TGQLGLGLKD EDEKMVSKPE EISSAHLDGY
560
SIIGASISDQ HTLIIAKKN
Length:569
Mass (Da):61,485
Last modified:November 1, 1996 - v1
Checksum:iED487D2CAA45AFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54327 Genomic DNA Translation: CAA91119.1
PIRiT19483
RefSeqiNP_495753.1, NM_063352.4
UniGeneiCel.7393

Genome annotation databases

EnsemblMetazoaiC26D10.1; C26D10.1; WBGene00004304
GeneIDi174332
KEGGicel:CELE_C26D10.1
UCSCiC26D10.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiRCC1_CAEEL
AccessioniPrimary (citable) accession number: Q18211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health