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Protein

Putative pyruvate, phosphate dikinase regulatory protein

Gene

CD630_24110

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.UniRule annotation

Catalytic activityi

ADP + [pyruvate, phosphate dikinase] = AMP + [pyruvate, phosphate dikinase] phosphate.UniRule annotation
[Pyruvate, phosphate dikinase] phosphate + phosphate = [pyruvate, phosphate dikinase] + diphosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 159ADPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyruvate, phosphate dikinase regulatory proteinUniRule annotation (EC:2.7.11.32UniRule annotation, EC:2.7.4.27UniRule annotation)
Short name:
PPDK regulatory proteinUniRule annotation
Gene namesi
Ordered Locus Names:CD630_24110
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003166631 – 280Putative pyruvate, phosphate dikinase regulatory proteinAdd BLAST280

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2411.

Structurei

3D structure databases

ProteinModelPortaliQ181Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CF9. Bacteria.
COG1806. LUCA.
HOGENOMiHOG000218052.
KOiK09773.
OMAiTSKTPTC.

Family and domain databases

HAMAPiMF_00921. PDRP. 1 hit.
InterProiIPR005177. Kinase-pyrophosphorylase.
IPR026565. PPDK_reg.
[Graphical view]
PfamiPF03618. Kinase-PPPase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q181Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKNLIIYA VSDSVGETAQ QVAKACMSQF YVNETYEIKR FPYMINKGVL
60 70 80 90 100
LETLENAKAE NALIVYTLVD EELCSIVERY CEREGLSCID LMTDILREIS
110 120 130 140 150
KRTGRKPKRE AGIIRKLDES YFKRVEAIEF AVKYDDGKDP RGVLQADIIL
160 170 180 190 200
VGISRTSKTP LSMYLANKNI KVANVPLVPE IPIPKEVFEI DTKKIIGLTN
210 220 230 240 250
SPEKLNEIRT QRLKALGLSS KANYANLERI LQELDYSEEI MKRIGCPVIN
260 270 280
VSNKAIEETA GIILDIMKEN GLKIYKEIEI
Length:280
Mass (Da):31,741
Last modified:July 25, 2006 - v1
Checksum:i94CA0AA7DF7119B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69296.1.
RefSeqiWP_004454708.1. NZ_CP010905.1.
YP_001088923.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69296; CAJ69296; CD630_24110.
GeneIDi4914300.
KEGGicdf:CD630_24110.
PATRICi19443285. VBICloDif38397_2529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69296.1.
RefSeqiWP_004454708.1. NZ_CP010905.1.
YP_001088923.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ181Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69296; CAJ69296; CD630_24110.
GeneIDi4914300.
KEGGicdf:CD630_24110.
PATRICi19443285. VBICloDif38397_2529.

Phylogenomic databases

eggNOGiENOG4105CF9. Bacteria.
COG1806. LUCA.
HOGENOMiHOG000218052.
KOiK09773.
OMAiTSKTPTC.

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2562-MONOMER.

Family and domain databases

HAMAPiMF_00921. PDRP. 1 hit.
InterProiIPR005177. Kinase-pyrophosphorylase.
IPR026565. PPDK_reg.
[Graphical view]
PfamiPF03618. Kinase-PPPase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDRP_PEPD6
AccessioniPrimary (citable) accession number: Q181Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.