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Q181T8 (PGK_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:CD630_31730
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceae

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000192818

Regions

Nucleotide binding356 – 3594ATP By similarity
Region24 – 263Substrate binding By similarity
Region62 – 654Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1231Substrate By similarity
Binding site1561Substrate By similarity
Binding site2071ATP By similarity
Binding site2981ATP; via carbonyl oxygen By similarity
Binding site3291ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q181T8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 91D1B75293119FD4

FASTA40043,066
        10         20         30         40         50         60 
MSMLNKKTIE DIDVCGKKVL VRCDFNVPLQ DGVITDENRL NGALPTIQYL ISKGAKVILC 

        70         80         90        100        110        120 
SHLGKPKGEA KPELSLAPVA KRLSEMLGKE VVFAADDNVV GENAKKATEK MENGDVVLLE 

       130        140        150        160        170        180 
NTRYRKEETK NEENFSKELA SLAEIFVNDA FGTAHRAHCS TVGAGEFLQE RVCGYLIQKE 

       190        200        210        220        230        240 
LKFLGEAVAN PVRPFTAILG GAKVSDKLAV INELLEKVDN LIIGGGMAYT FLKAQGYEVG 

       250        260        270        280        290        300 
TSLLEIDKVE YAKEMMEKAK NKGVNLLLPV DVVMADHFAP DATPIVTEDA NVKEDYMGLD 

       310        320        330        340        350        360 
MGPKTIANFV KTIKESKTVV WNGPMGVFEF ENFANGTLSV ARAMAELTDA TTVIGGGDSA 

       370        380        390        400 
AAVNQLGFGD KMTHVSTGGG ASLEFLEGKE LPGIAALDNK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ70070.1.
RefSeqYP_001089690.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ181T8.
SMRQ181T8. Positions 5-400.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD3173.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ70070; CAJ70070; CD630_31730.
GeneID4913221.
KEGGcdf:CD630_31730.
PATRIC19444881. VBICloDif38397_3324.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAGLDCGEK.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-3414-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_CLOD6
AccessionPrimary (citable) accession number: Q181T8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways