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Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N(3)-methylpseudouridine(1915) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3917-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
23S rRNA m3Psi1915 methyltransferaseUniRule annotation
rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
Gene namesi
Name:rlmHUniRule annotation
Ordered Locus Names:CD630_36490
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Ribosomal RNA large subunit methyltransferase HPRO_0000260545Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD3649.

Structurei

3D structure databases

ProteinModelPortaliQ181Q1.
SMRiQ181Q1. Positions 1-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA methyltransferase RlmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UXA. Bacteria.
COG1576. LUCA.
HOGENOMiHOG000218433.
KOiK00783.
OMAiNGEPYHK.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00658. 23SrRNA_methyltr_H. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR016051. RlmH.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFiPIRSF004505. MT_bac. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00246. tRNA_RlmH_YbeA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q181Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISIVVVGK IKEKYLKLGI DEFKKRLSKY CKLEIIELDD EKAPENLSVK
60 70 80 90 100
EMEIIKDKEG KKILGKIKHN SYVIALAIDG KGLSSEELAK TMSDLAVRGN
110 120 130 140 150
SSLCFIIGGS LGLSDEVLGR ADYRLSFSRM TFPHQMMRLI LLEQIYRAYR

INNGEPYHK
Length:159
Mass (Da):18,083
Last modified:July 25, 2006 - v1
Checksum:i8B90FA9E26A795BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70557.1.
RefSeqiWP_003435703.1. NZ_CP010905.1.
YP_001090173.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ70557; CAJ70557; CD630_36490.
GeneIDi4913596.
KEGGicdf:CD630_36490.
pdc:CDIF630_03973.
PATRICi19445893. VBICloDif38397_3824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70557.1.
RefSeqiWP_003435703.1. NZ_CP010905.1.
YP_001090173.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ181Q1.
SMRiQ181Q1. Positions 1-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ70557; CAJ70557; CD630_36490.
GeneIDi4913596.
KEGGicdf:CD630_36490.
pdc:CDIF630_03973.
PATRICi19445893. VBICloDif38397_3824.

Phylogenomic databases

eggNOGiENOG4108UXA. Bacteria.
COG1576. LUCA.
HOGENOMiHOG000218433.
KOiK00783.
OMAiNGEPYHK.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3917-MONOMER.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00658. 23SrRNA_methyltr_H. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR016051. RlmH.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFiPIRSF004505. MT_bac. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00246. tRNA_RlmH_YbeA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMH_PEPD6
AccessioniPrimary (citable) accession number: Q181Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.