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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001SubstrateUniRule annotation
Active sitei109 – 1091Proton acceptorUniRule annotation
Metal bindingi129 – 1291Monovalent cationUniRule annotation
Binding sitei132 – 1321ATPUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 138ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3820-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:CD630_35550
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Type III pantothenate kinasePRO_0000267511Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD3555.

Structurei

3D structure databases

ProteinModelPortaliQ181F7.
SMRiQ181F7. Positions 1-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1104Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.
OrthoDBiEOG6G20K0.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q181F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVFDVGNT NMVLGIYKGD KLVNYWRIKT DREKTSDEYG ILISNLFDYD
60 70 80 90 100
NVNISDIDDV IISSVVPNVM HSLENFCIKY CKKQPLIVGP GIKTGLNIKY
110 120 130 140 150
DNPKQVGADR IVNAVAGIEK YGAPSILVDF GTATTFCAIS EKGEYLGGTI
160 170 180 190 200
APGIKISSEA LFQSASKLPR VELAKPGMTI CKSTVSAMQS GIIYGYVGLV
210 220 230 240 250
DKIISIMKKE LNCDDVKVIA TGGLAKLIAS ETKSIDYVDG FLTLEGLRII

YEKNQE
Length:256
Mass (Da):27,939
Last modified:July 25, 2006 - v1
Checksum:i0FC1613661537AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70461.1.
RefSeqiWP_011861999.1. NZ_CP010905.1.
YP_001090078.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ70461; CAJ70461; CD630_35550.
GeneIDi4912891.
KEGGicdf:CD630_35550.
pdc:CDIF630_03875.
PATRICi19445695. VBICloDif38397_3725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70461.1.
RefSeqiWP_011861999.1. NZ_CP010905.1.
YP_001090078.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ181F7.
SMRiQ181F7. Positions 1-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ70461; CAJ70461; CD630_35550.
GeneIDi4912891.
KEGGicdf:CD630_35550.
pdc:CDIF630_03875.
PATRICi19445695. VBICloDif38397_3725.

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.
OrthoDBiEOG6G20K0.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciCDIF272563:GJFE-3820-MONOMER.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiCOAX_PEPD6
AccessioniPrimary (citable) accession number: Q181F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: November 11, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.