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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3739-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:CD630_35530
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000342551 – 159Transcription elongation factor GreAAdd BLAST159

Proteomic databases

PRIDEiQ181F4

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272563.CD3553

Structurei

3D structure databases

ProteinModelPortaliQ181F4
SMRiQ181F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 77UniRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4108UKH Bacteria
COG0782 LUCA
HOGENOMiHOG000241145
KOiK03624
OMAiTWLTQEA

Family and domain databases

Gene3Di1.10.287.180, 1 hit
3.10.50.30, 1 hit
HAMAPiMF_00105 GreA_GreB, 1 hit
InterProiView protein in InterPro
IPR036953 GreA/GreB_C_sf
IPR018151 TF_GreA/GreB_CS
IPR006359 Tscrpt_elong_fac_GreA
IPR028624 Tscrpt_elong_fac_GreA/B
IPR001437 Tscrpt_elong_fac_GreA/B_C
IPR023459 Tscrpt_elong_fac_GreA/B_fam
IPR022691 Tscrpt_elong_fac_GreA/B_N
IPR036805 Tscrpt_elong_fac_GreA/B_N_sf
PANTHERiPTHR30437 PTHR30437, 1 hit
PfamiView protein in Pfam
PF01272 GreA_GreB, 1 hit
PF03449 GreA_GreB_N, 1 hit
PIRSFiPIRSF006092 GreA_GreB, 1 hit
SUPFAMiSSF46557 SSF46557, 1 hit
TIGRFAMsiTIGR01462 greA, 1 hit
PROSITEiView protein in PROSITE
PS00829 GREAB_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q181F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEENKEFLLT QEGYDKLEEE LENLKVVKRK EVAERIKVAI SFGDLSENAE
60 70 80 90 100
YDEAKKEQAQ VEERILKLEN MVRKAVIIDE SKIDLNVVTI GSIVKVKDLE
110 120 130 140 150
FDEEVEYTIV GSTEADPYDG KISNESPVGK ALLGRAAKEV VEVQVPDGVA

KFEILEIRR
Length:159
Mass (Da):18,013
Last modified:July 25, 2006 - v1
Checksum:i2911D43A8A3BE9BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ70459.1
RefSeqiWP_003422204.1, NZ_CP010905.2
YP_001090076.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ70459; CAJ70459; CD630_35530
GeneIDi31355234
4912889
KEGGicdf:CD630_35530
pdc:CDIF630_03873
PATRICifig|272563.120.peg.3756

Similar proteinsi

Entry informationi

Entry nameiGREA_PEPD6
AccessioniPrimary (citable) accession number: Q181F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health