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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3818-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:CD630_35530
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Transcription elongation factor GreAPRO_1000034255Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD3553.

Structurei

3D structure databases

ProteinModelPortaliQ181F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2 – 7776UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4108UKH. Bacteria.
COG0782. LUCA.
HOGENOMiHOG000241145.
KOiK03624.
OMAiHNEGRIA.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB. 1 hit.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q181F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEENKEFLLT QEGYDKLEEE LENLKVVKRK EVAERIKVAI SFGDLSENAE
60 70 80 90 100
YDEAKKEQAQ VEERILKLEN MVRKAVIIDE SKIDLNVVTI GSIVKVKDLE
110 120 130 140 150
FDEEVEYTIV GSTEADPYDG KISNESPVGK ALLGRAAKEV VEVQVPDGVA

KFEILEIRR
Length:159
Mass (Da):18,013
Last modified:July 25, 2006 - v1
Checksum:i2911D43A8A3BE9BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70459.1.
RefSeqiWP_003422204.1. NZ_CP010905.1.
YP_001090076.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ70459; CAJ70459; CD630_35530.
GeneIDi4912889.
KEGGicdf:CD630_35530.
pdc:CDIF630_03873.
PATRICi19445691. VBICloDif38397_3723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70459.1.
RefSeqiWP_003422204.1. NZ_CP010905.1.
YP_001090076.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ181F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ70459; CAJ70459; CD630_35530.
GeneIDi4912889.
KEGGicdf:CD630_35530.
pdc:CDIF630_03873.
PATRICi19445691. VBICloDif38397_3723.

Phylogenomic databases

eggNOGiENOG4108UKH. Bacteria.
COG0782. LUCA.
HOGENOMiHOG000241145.
KOiK03624.
OMAiHNEGRIA.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3818-MONOMER.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB. 1 hit.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGREA_PEPD6
AccessioniPrimary (citable) accession number: Q181F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.