Q18195 (ELP4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative elongator complex protein 4
Short name=ELP4

Gene names

Name:	elpc-4
ORF Names:	C26B2.6

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation By similarity.
Subunit structure	Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the ELP4 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB reproduction Inferred from mutant phenotype. Source: WormBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Elongator holoenzyme complex Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB transcription elongation factor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	phosphorylase kinase regulator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Putative elongator complex protein 4		PRO_0000284009

Sequences

	Sequence		Length	Mass (Da)
	Q18195 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C9CC5643E6CABF1E	FASTA	334	37,632
	10 20 30 40 50 60 MLNVGDSVQI AGCSTKKRLL ETSSGCDSFD TLIGGALVNS SIVLIDEYRS RCYGSYLIRS 70 80 90 100 110 120 FLAEGLHHGH RCFIADPTED PKEINLIPSR RTSTDMQNQE IPNSLPAENE NSMKIAWRYG 130 140 150 160 170 180 NVKQVSSSLG PLSNENQYDF TKHVENPNVD VYAEKVFTLK GIYETLCQIV KENEAHTKSG 190 200 210 220 230 240 GRGGPKKNLL RVVLKNIDME ICEDYKFLGR FLCCLRSLAR SSYMIVYITA NSFRVPKPTW 250 260 270 280 290 300 RILESAADTH IQLMPFDENE KKMFKHLGTA HGYFHLKSLP RLMSVGTHTP PILDLIFEAS 310 320 330 SRKGFQIRVM HLPPAFDEPA PGHQNTPSCQ NIDF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080616 Genomic DNA. Translation: CCD65198.1.
PIR	T34124.
RefSeq	NP_501343.1. NM_068942.4.
UniGene	Cel.37601.
3D structure databases
ProteinModelPortal	Q18195.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26243N.
IntAct	Q18195. 3 interactions.
MINT	MINT-1052341.
Proteomic databases
PRIDE	Q18195.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C26B2.6; C26B2.6; C26B2.6.
GeneID	182929.
KEGG	cel:C26B2.6.
NMPDR	fig|6239.3.peg.14126.
UCSC	C26B2.6. c. elegans.
Organism-specific databases
CTD	182929.
WormBase	C26B2.6; CE04092; WBGene00016128; elpc-4.
Phylogenomic databases
eggNOG	meNOG07998.
GeneTree	EMGT00050000017192.
HOGENOM	HBG383948.
InParanoid	Q18195.
OMA	AADTHIQ.
PhylomeDB	Q18195.
Gene expression databases
ArrayExpress	Q18195.
Family and domain databases
InterPro	IPR008728. Elongator_complex_protein_4. [Graphical view]
KO	K11375.
Pfam	PF05625. PAXNEB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	919324.

Entry information

Entry name

ELP4_CAEEL

Accession

Primary (citable) accession number: Q18195

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project