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Protein

Tyrosine-protein kinase

Gene

C25A8.5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ18142.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:C25A8.5Imported, CELE_C25A8.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC25A8.5; CE08385; WBGene00016085.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ18142.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C25A8.5.

Structurei

3D structure databases

ProteinModelPortaliQ18142.
SMRiQ18142. Positions 4-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 10898SH2InterPro annotationAdd
BLAST
Domaini120 – 378259Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ18142.
OMAiVEDCAIK.
OrthoDBiEOG708VXW.
PhylomeDBiQ18142.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDKDIPSEP WYHGLLPRED IKAMLRKNGD FLVRSTEPKA GEPRQYVLSA
60 70 80 90 100
MQSEELEDAG VKHYVMRLNP SNQIFLEAKG FETIASLVNY YMNSKEPIKK
110 120 130 140 150
MTVLKTPILK QPWEIEHSQV ELTKKLGEGA FGEVWKGKLT LKNGTVENCA
160 170 180 190 200
IKTAKLESLN KEQIKEIMRE ARLMRNLDHP NVVKFYGVGA SQEPLYVIME
210 220 230 240 250
LADCGALDSY LQKNPNLLPG KKMEMIYQAA CGIAYMHEKK LLHRDIAARN
260 270 280 290 300
CLYGEGQVKI ADFGLSREGN SYVMDLTKKV PIRWLAPETL KAGIYSPKSD
310 320 330 340 350
VFAFGIMAWE ITENGKEPYP DMRVSEVVGY VRSGHRMRFD PVFVDFRFGE
360 370 380 390 400
YVTKHCWAEN PDDRVNMSDV LRYLQTTFGM KPVILSLRNR TTTDDEMKTM
410
KPPMFSMKRK DKKKPK
Length:416
Mass (Da):47,801
Last modified:November 1, 1996 - v1
Checksum:i6D9F549FAAFDBF4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63430.1.
PIRiT29805.
RefSeqiNP_501081.1. NM_068680.1.
UniGeneiCel.13484.

Genome annotation databases

EnsemblMetazoaiC25A8.5; C25A8.5; WBGene00016085.
GeneIDi182879.
KEGGicel:CELE_C25A8.5.
UCSCiC25A8.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63430.1.
PIRiT29805.
RefSeqiNP_501081.1. NM_068680.1.
UniGeneiCel.13484.

3D structure databases

ProteinModelPortaliQ18142.
SMRiQ18142. Positions 4-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C25A8.5.

Proteomic databases

PaxDbiQ18142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC25A8.5; C25A8.5; WBGene00016085.
GeneIDi182879.
KEGGicel:CELE_C25A8.5.
UCSCiC25A8.5. c. elegans.

Organism-specific databases

CTDi182879.
WormBaseiC25A8.5; CE08385; WBGene00016085.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ18142.
OMAiVEDCAIK.
OrthoDBiEOG708VXW.
PhylomeDBiQ18142.

Enzyme and pathway databases

SignaLinkiQ18142.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ18142_CAEEL
AccessioniPrimary (citable) accession number: Q18142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.