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Protein

Tyrosine-protein kinase

Gene

C25A8.5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ18142.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:C25A8.5Imported, CELE_C25A8.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC25A8.5; CE08385; WBGene00016085.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ18142.
PeptideAtlasiQ18142.

Expressioni

Gene expression databases

BgeeiWBGene00016085.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C25A8.5.

Structurei

3D structure databases

ProteinModelPortaliQ18142.
SMRiQ18142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 108SH2InterPro annotationAdd BLAST98
Domaini120 – 378Protein kinaseInterPro annotationAdd BLAST259

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ18142.
OMAiVMELANK.
OrthoDBiEOG091G087L.
PhylomeDBiQ18142.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDKDIPSEP WYHGLLPRED IKAMLRKNGD FLVRSTEPKA GEPRQYVLSA
60 70 80 90 100
MQSEELEDAG VKHYVMRLNP SNQIFLEAKG FETIASLVNY YMNSKEPIKK
110 120 130 140 150
MTVLKTPILK QPWEIEHSQV ELTKKLGEGA FGEVWKGKLT LKNGTVENCA
160 170 180 190 200
IKTAKLESLN KEQIKEIMRE ARLMRNLDHP NVVKFYGVGA SQEPLYVIME
210 220 230 240 250
LADCGALDSY LQKNPNLLPG KKMEMIYQAA CGIAYMHEKK LLHRDIAARN
260 270 280 290 300
CLYGEGQVKI ADFGLSREGN SYVMDLTKKV PIRWLAPETL KAGIYSPKSD
310 320 330 340 350
VFAFGIMAWE ITENGKEPYP DMRVSEVVGY VRSGHRMRFD PVFVDFRFGE
360 370 380 390 400
YVTKHCWAEN PDDRVNMSDV LRYLQTTFGM KPVILSLRNR TTTDDEMKTM
410
KPPMFSMKRK DKKKPK
Length:416
Mass (Da):47,801
Last modified:November 1, 1996 - v1
Checksum:i6D9F549FAAFDBF4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63430.1.
PIRiT29805.
RefSeqiNP_501081.1. NM_068680.1.
UniGeneiCel.13484.

Genome annotation databases

EnsemblMetazoaiC25A8.5; C25A8.5; WBGene00016085.
GeneIDi182879.
KEGGicel:CELE_C25A8.5.
UCSCiC25A8.5. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ18142_CAEEL
AccessioniPrimary (citable) accession number: Q18142
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported