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Protein

26S proteasome non-ATPase regulatory subunit 1

Gene

rpn-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

  • enzyme regulator activity Source: InterPro
  • protein kinase C binding Source: WormBase

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 1
Alternative name(s):
26S proteasome regulatory subunit rpn-2
Gene namesi
Name:rpn-2
ORF Names:C23G10.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC23G10.4a; CE40437; WBGene00004459; rpn-2.
C23G10.4b; CE31311; WBGene00004459; rpn-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738031 – 96526S proteasome non-ATPase regulatory subunit 1Add BLAST965

Proteomic databases

EPDiQ18115.
PaxDbiQ18115.
PeptideAtlasiQ18115.
PRIDEiQ18115.

Expressioni

Gene expression databases

BgeeiWBGene00004459.

Interactioni

GO - Molecular functioni

  • protein kinase C binding Source: WormBase

Protein-protein interaction databases

BioGridi41098. 11 interactors.
IntActiQ18115. 10 interactors.
MINTiMINT-210658.
STRINGi6239.C23G10.4b.2.

Structurei

3D structure databases

ProteinModelPortaliQ18115.
SMRiQ18115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati380 – 413PC 1Add BLAST34
Repeati418 – 452PC 2Add BLAST35
Repeati454 – 488PC 3Add BLAST35
Repeati489 – 523PC 4Add BLAST35
Repeati560 – 595PC 5Add BLAST36
Repeati630 – 664PC 6Add BLAST35
Repeati665 – 706PC 7Add BLAST42
Repeati708 – 738PC 8Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi841 – 844Poly-Ala4
Compositional biasi846 – 851Poly-Ser6

Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2062. Eukaryota.
COG5116. LUCA.
GeneTreeiENSGT00550000074915.
HOGENOMiHOG000189403.
InParanoidiQ18115.
KOiK03032.
OMAiRNCTIGL.
OrthoDBiEOG091G01IW.
PhylomeDBiQ18115.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
IPR035266. PSMD1.
PANTHERiPTHR10943:SF2. PTHR10943:SF2. 1 hit.
PfamiView protein in Pfam
PF01851. PC_rep. 3 hits.
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q18115-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTLLNRWRS QPGGASNAAA FIRVLESPKS AVTDKVLVLK AFNDWDVLVN
60 70 80 90 100
TWFEVADALP AVEQLLDNNT FPEHSSAALL VSKVYFCLEQ YERALEFALR
110 120 130 140 150
GDFNVVPATR TGLGNDAEYV NKIIETAIDT YKTLSKQGSG IPQKLRDLID
160 170 180 190 200
RIVARNLDKR EIWFVISLGF ETTNLAMIDR AISAMPADLT IKNQTTLVET
210 220 230 240 250
LNRVVNGAFD RSFRFQVIDT VIKTYLKCPS PDMSKICECY VLTDNAEAAA
260 270 280 290 300
DTITSLIAKS LSTRAYQIAF DLYETASQGF LDRVLKRFQQ QDARDEKSME
310 320 330 340 350
KIHSILKGHE TVKAYLDFFV RHNHTDSVLM EEIKENIRTA SAHNALLISN
360 370 380 390 400
GLMQYGTTCD DFLRNNLNWV SKATNWNKFN AVASLGLIHH GQESSAMKVL
410 420 430 440 450
EPYLPKESVE GFGFKEGGAM LAYGLIHAKH GDATAMSTLA QWLKTAENEP
460 470 480 490 500
VRHGACLGFG VAGLGSSSVS NYEKVREVLQ RDEAVSGESA GIAMGLIMAG
510 520 530 540 550
HLNQEVFNEL KQYTVDTQHD KTQRGIRTGL ACAAFGLQGD AEPYIKEAIG
560 570 580 590 600
AKSNPMLRST GICMLSMAYA GTGSPDVVRR LLEKVATDPN LDVKRYATIG
610 620 630 640 650
IGFVLSKDPS TCLSYVAMLT EHFNGHVRYG AAMALGIACA GTGNMEAIAL
660 670 680 690 700
IEPMISDKEG FVRKGALLSL ALIMCQQTDY TCPKVNGFRK QLLKKIGEKN
710 720 730 740 750
EDSLVKFGAI IAQGLLDIGG QNAAVTMQNS DKQPDMGSMV GMMCFLHGWF
760 770 780 790 800
WHSMHFFIAL AAKPSCLVMM NENLKIPVLD YICHANSQKF AYPPRAESKK
810 820 830 840 850
DKDVKKIETV VLSITGKKNA SKKLIAEEKK RREAAASASS AAAAPSSSST
860 870 880 890 900
SGTAPAAEDE KMEVDQPGKS KKEKAPEKDT KPLHRLQNPA RVIPAQRQLI
910 920 930 940 950
SISDARAYSP MKPLYKGGII VADRVDKERE EKLVSEVVTQ VNTPASSGNT
960
ENKPHSTFEI NINDF
Length:965
Mass (Da):106,008
Last modified:January 27, 2003 - v4
Checksum:i3015F13EF0D9B6DB
GO
Isoform a (identifier: Q18115-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-965: Missing.

Note: No experimental confirmation available.
Show »
Length:871
Mass (Da):95,473
Checksum:i9CC30C216F990357
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041849872 – 965Missing in isoform a. CuratedAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080630 Genomic DNA. Translation: CCD65306.1.
FO080630 Genomic DNA. Translation: CCD65298.1.
RefSeqiNP_498346.2. NM_065945.5. [Q18115-1]
NP_498347.3. NM_065946.5. [Q18115-2]
UniGeneiCel.17756.

Genome annotation databases

EnsemblMetazoaiC23G10.4b.1; C23G10.4b.1; WBGene00004459. [Q18115-1]
C23G10.4b.2; C23G10.4b.2; WBGene00004459. [Q18115-1]
GeneIDi175877.
KEGGicel:CELE_C23G10.4.
UCSCiC23G10.4a.1. c. elegans. [Q18115-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPSMD1_CAEEL
AccessioniPrimary (citable) accession number: Q18115
Secondary accession number(s): Q18114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 27, 2003
Last modified: November 22, 2017
This is version 145 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families