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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cobB)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3606-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:CD630_34290
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002577561 – 408Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST408

Proteomic databases

PRIDEiQ180S8

Interactioni

Protein-protein interaction databases

STRINGi272563.CD3429

Structurei

3D structure databases

ProteinModelPortaliQ180S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 2 hits
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

Q180S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYVYIDGK KYRRGYTTGS CATGASKAAV YMLITKNRIN TINIDTPKGI
60 70 80 90 100
PLLLKVDNIN ISDTFVECSI KKDGGDDIDA THTMDIYARA EIVAKNDKNK
110 120 130 140 150
GYLTLKDIDS LSTNSECKSE LYKFIRVYGG TGIGVVTKKG LSVDVGKPAI
160 170 180 190 200
NPTPLKMINH EIRKLIGDNF ESILGNDKVL KITIFAPQGE TVAKKTFNPR
210 220 230 240 250
LGIVGGISII GTTGIVEPMS DDGWKKSLSI ELQMKKEQGL DKIILVPGNH
260 270 280 290 300
GEQFIREKLN LDIKYVVRVS NFIGYMIKEA QRIGYKKILM AGHIGKFIKV
310 320 330 340 350
SAGIFNTHSK VADARSEILV ANLALMGARY EFLNKINQCV TTEEAVELIN
360 370 380 390 400
NSEYREVYNI LSNKCRERVK QYLNEDSDDI DVEVIIFSMD KSLLGKSDNT

DDLVEVFI
Length:408
Mass (Da):45,430
Last modified:July 25, 2006 - v1
Checksum:iF349930F08E053D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ70332.1
RefSeqiWP_011861964.1, NZ_CP010905.2
YP_001089949.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ70332; CAJ70332; CD630_34290
GeneIDi31355102
4913191
KEGGicdf:CD630_34290
pdc:CDIF630_03737
PATRICifig|272563.120.peg.3623

Similar proteinsi

Entry informationi

Entry nameiCBID_PEPD6
AccessioniPrimary (citable) accession number: Q180S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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