Q180R8 (Q180R8_CLOD6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase EMBL CAJ70323.2
EC=2.1.1.107 EMBL CAJ70323.2
EC=4.2.1.75 EMBL CAJ70323.2

Gene names

Name:	cobA + hemD EMBL CAJ70323.2
Ordered Locus Names:	CD630_34200

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine SAAS SAAS014776
Molecular function	Lyase EMBL CAJ70323.2 Methyltransferase SAAS SAAS006366 EMBL CAJ70323.2 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	precorrin-2 dehydrogenase activity Inferred from electronic annotation. Source: InterPro uroporphyrin-III C-methyltransferase activity Inferred from electronic annotation. Source: EC uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q180R8 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: BF788795172E193D	FASTA	499	55,425
	10 20 30 40 50 60 MKGKVYLVGA GPGDYKLMTL KGLECIRKSD VIVYDRLANS SYLREAKPDC ELIYVGKASS 70 80 90 100 110 120 NHILPQEDIN RIIAEKAKEG KIVTRLKGGD PYVFGRGGEE AETLVDEGIE FEVVPGITSA 130 140 150 160 170 180 IGGLCYAGIP ITHRDHASSF HVITGHLKGD DSGELNWNAL ANNKGTLVFL MGISNLEKIS 190 200 210 220 230 240 ENLMKEGKDK DTPVALISWA TRYNQRVVTS TLENVYETAI KEEVKPPTLI VVGSVVGLRE 250 260 270 280 290 300 KLNFFESKPL FGKSIAVTRS RNQNSVLVEK IMDLGGNPIE IPTIKVEKIQ NNINLENEIK 310 320 330 340 350 360 NINKYNYLIL TSKNAVEIFF EKIYEMNFDL RILSNLKVCA IGSATSNELK KRGIIADIVP 370 380 390 400 410 420 KKFVAESLYE ELAPILNDDD NILIPRAENA RDYLVDKLKA ICEVTEVHIY RTVIDEEKKG 430 440 450 460 470 480 EILDILNSND IDYITFTSSS TVNNLVEIIG KENIKILEKI KTLSIGPITT ETINSLGIKL 490 YKESATSTID SLVDLIIKN

References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome." Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T. , Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J. Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 630.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180355 Genomic DNA. Translation: CAJ70323.2.
RefSeq	YP_001089940.1. NC_009089.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q180R8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4913182.
GenomeReviews	Gene locus CD3420 in contig AM180355_GR.
KEGG	cdf:CD3420.
PATRIC	19445405. VBICloDif38397_3583.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ETREMIK.
Family and domain databases
InterPro	IPR000878. 4pyrrol_Mease. IPR003754. 4pyrrol_synth_uPrphyn_synth. IPR014777. 4pyrrole_Mease_sub1. IPR014776. 4pyrrole_Mease_sub2. IPR006366. CobA_cysG_C. IPR003043. Uropor_MeTrfase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1010.10. 4pyrrole_Mease_sub1. 1 hit. G3DSA:3.30.950.10. 4pyrrole_Mease_sub2. 1 hit.
KO	K13542.
Pfam	PF02602. HEM4. 1 hit. PF00590. TP_methylase. 1 hit. [Graphical view]
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit. SSF69618. HEM4_synth. 1 hit.
TIGRFAMs	TIGR01469. CobA_cysG_Cterm. 1 hit.
PROSITE	PS00839. SUMT_1. 1 hit. PS00840. SUMT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q180R8_CLOD6

Accession

Primary (citable) accession number: Q180R8

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	June 28, 2011
Last modified:	January 25, 2012
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)