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Q180R0 (Q180R0_CLOD6) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UvrABC system protein B HAMAP-Rule MF_00204
Short name=Protein UvrB HAMAP-Rule MF_00204
Alternative name(s):
Excinuclease ABC subunit B HAMAP-Rule MF_00204
Gene names
Name:uvrB HAMAP-Rule MF_00204 EMBL CAJ70315.1
Ordered Locus Names:CD630_34120 EMBL CAJ70315.1
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP] EMBL CAJ70315.1
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptostreptococcaceae ›

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity. SAAS SAAS006935 HAMAP-Rule MF_00204

Subunit structure

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity. SAAS SAAS006935 HAMAP-Rule MF_00204 RuleBase RU003587

Subcellular location

Cytoplasm By similarity SAAS SAAS006935 HAMAP-Rule MF_00204 RuleBase RU003587.

Domain

The beta-hairpin motif is involved in DNA binding By similarity. HAMAP-Rule MF_00204

Sequence similarities

Belongs to the UvrB family. HAMAP-Rule MF_00204 RuleBase RU003587

Contains 1 UVR domain. SAAS SAAS006935 HAMAP-Rule MF_00204 RuleBase RU003587

Contains 1 helicase ATP-binding domain. SAAS SAAS004807 HAMAP-Rule MF_00204

Contains 1 helicase C-terminal domain. HAMAP-Rule MF_00204 SAAS SAAS004807

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain24 – 179156Helicase ATP-binding By similarity HAMAP-Rule MF_00204
Domain428 – 590163Helicase C-terminal By similarity HAMAP-Rule MF_00204
Domain618 – 65336UVR By similarity HAMAP-Rule MF_00204
Nucleotide binding37 – 448ATP By similarity HAMAP-Rule MF_00204
Motif90 – 11324Beta-hairpin By similarity HAMAP-Rule MF_00204

Sequences

Sequence LengthMass (Da)Tools
Q180R0 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 64E36B74DBD1FE0A

FASTA65675,630
        10         20         30         40         50         60 
MDFKIKSDFK PTGDQPEAIK SIVDSINRNE KFSTLLGVTG SGKTFTMANI IQQVKKPTLI 

        70         80         90        100        110        120 
MAHNKTLAAQ LYSEFKEFFP DNAVEYFVSY YDYYQPEAYV AHSDTYIEKD ASINDEIDKL 

       130        140        150        160        170        180 
RHSATASILE RRDTIIISSV SCIYGLGDPK DYKELMLSIR PGMQRDRDDV IKRLIEIQYE 

       190        200        210        220        230        240 
RNDINFTRGT FRVRGDILEI FPASNDEKAI RIEFFGDEVD RITEIDYVTG KIVGTRNHVV 

       250        260        270        280        290        300 
IFPASHYVTT PERIEKAIVE IENELQEQIK FFKENDRLLE AQRIEQRTKY DIEMLKEIGF 

       310        320        330        340        350        360 
CQGIENYSRH ITGRSEGERP YTLMDFFPDD YLIIVDEAHV TIPQVRGMYA GDRSRKTSLI 

       370        380        390        400        410        420 
ENGFRLPSAL DNRPLNFQEF EGNINQMLFV SATPGPYEIQ HSETIAEQII RPTGLLDPIV 

       430        440        450        460        470        480 
EVRPINNQID DLVGEITKTI EKNERVLITT LTKKMSEDLT NYLKEIGIKV KYLHSDIVTL 

       490        500        510        520        530        540 
ERTEIIRDLR LGKFDVLVGI NLLREGLDIP EVSLIAILDA DKEGFLRSET ALIQTIGRAA 

       550        560        570        580        590        600 
RNENGRVIMY ADRITDSMQN AIDETKRRRD IQNLYNEEHN IIPKTIQKNI RDSIEATKVA 

       610        620        630        640        650 
EEEVVYGISD TDDKDEIRAN IDKLKSEMME AAQNLQFERA AELRDKVKQL EEKLEK

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM180355 Genomic DNA. Translation: CAJ70315.1.
RefSeqYP_001089932.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ180R0.
SMRQ180R0. Positions 3-645.
ModBaseSearch...

Protein-protein interaction databases

STRING272563.CD3412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ70315; CAJ70315; CD630_34120.
GeneID4914869.
KEGGcdf:CD630_34120.
PATRIC19445383. VBICloDif38397_3575.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0556.
HOGENOMHOG000073580.
KOK03702.
OMACIYGLGI.
ProtClustDBPRK05298.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-3666-MONOMER.

Family and domain databases

Gene3D4.10.860.10. 1 hit.
HAMAPMF_00204. UvrB.
InterProIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERPTHR24029. PTHR24029. 1 hit.
PfamPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF46600. UvrB_C. 1 hit.
TIGRFAMsTIGR00631. uvrb. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ180R0_CLOD6
AccessionPrimary (citable) accession number: Q180R0
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 29, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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