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Protein

UvrABC system protein C

Gene

uvrC

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3584-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:CD630_34100
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002648841 – 605UvrABC system protein CAdd BLAST605

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD3410

Structurei

3D structure databases

ProteinModelPortaliQ180Q8
SMRiQ180Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 92GIY-YIGUniRule annotationAdd BLAST80
Domaini205 – 240UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279960
KOiK03703
OMAiLFPIRQC

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

Q180Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDIQEHLKK LPSEPGVYLM KDKYDHIIYV GKAISLKNRV RQYFQSSKNH
60 70 80 90 100
TSKVKSMVKN IYKFEYIITD SELEALILEC NLIKRYRPKY NVVLRDDKTY
110 120 130 140 150
PYIKVTTNED YPRILKVRRV LKDKAKYFGP YTNITAVNDT LELISSTYPI
160 170 180 190 200
RSCKIDIDKA IKNKTRPCLN LHINKCLGPC TGNVSKEEYG KMIEEIIMCL
210 220 230 240 250
SGKEEKLMEL LKEKMNESSM NFRFEEAAVY RDKIKSLEEM IQKQKIDATV
260 270 280 290 300
SDLNQDVVAM ARAHNEACVQ VFFIRNGKIV GREHFILEGV MDSPRASILS
310 320 330 340 350
SFVKQFYNEQ EYIPKELIIE DEIEDSSILE EWLSSKKGQK VTIRVPQKGE
360 370 380 390 400
KKSLVEMVRK NAVEYLEKFS DMNKRKYEKS IGALEELKQI LNLEKLPIRI
410 420 430 440 450
EAYDISNIQG VDSIGSMVVY TNAKKDKKEY RRYKIKTVIG PNDYDSMAEI
460 470 480 490 500
VDRRLKHGNL PDLILLDGGK GQVSAVKKVL ELNDVDIPLW GMYKDDKHRT
510 520 530 540 550
KGLICKEKEI ELDKTTNLYR FIASIQEEVH NYAITYHRSL RNKALTKSIL
560 570 580 590 600
DDIQGIGEKR KKSLLNHFKD VDAIKKATME ELLEVDGMNK SIADNVYNFF

RKEEN
Length:605
Mass (Da):70,356
Last modified:July 25, 2006 - v1
Checksum:iF64DD341F6EB7924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ70313.1
RefSeqiWP_003436264.1, NZ_CP010905.2
YP_001089930.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ70313; CAJ70313; CD630_34100
GeneIDi31355080
4915787
KEGGicdf:CD630_34100
pdc:CDIF630_03715
PATRICifig|272563.120.peg.3604

Similar proteinsi

Entry informationi

Entry nameiUVRC_PEPD6
AccessioniPrimary (citable) accession number: Q180Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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