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Protein

UvrABC system protein C

Gene

uvrC

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:CD630_34100
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605UvrABC system protein CPRO_0000264884Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD3410.

Structurei

3D structure databases

ProteinModelPortaliQ180Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9280GIY-YIGUniRule annotationAdd
BLAST
Domaini205 – 24036UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q180Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDIQEHLKK LPSEPGVYLM KDKYDHIIYV GKAISLKNRV RQYFQSSKNH
60 70 80 90 100
TSKVKSMVKN IYKFEYIITD SELEALILEC NLIKRYRPKY NVVLRDDKTY
110 120 130 140 150
PYIKVTTNED YPRILKVRRV LKDKAKYFGP YTNITAVNDT LELISSTYPI
160 170 180 190 200
RSCKIDIDKA IKNKTRPCLN LHINKCLGPC TGNVSKEEYG KMIEEIIMCL
210 220 230 240 250
SGKEEKLMEL LKEKMNESSM NFRFEEAAVY RDKIKSLEEM IQKQKIDATV
260 270 280 290 300
SDLNQDVVAM ARAHNEACVQ VFFIRNGKIV GREHFILEGV MDSPRASILS
310 320 330 340 350
SFVKQFYNEQ EYIPKELIIE DEIEDSSILE EWLSSKKGQK VTIRVPQKGE
360 370 380 390 400
KKSLVEMVRK NAVEYLEKFS DMNKRKYEKS IGALEELKQI LNLEKLPIRI
410 420 430 440 450
EAYDISNIQG VDSIGSMVVY TNAKKDKKEY RRYKIKTVIG PNDYDSMAEI
460 470 480 490 500
VDRRLKHGNL PDLILLDGGK GQVSAVKKVL ELNDVDIPLW GMYKDDKHRT
510 520 530 540 550
KGLICKEKEI ELDKTTNLYR FIASIQEEVH NYAITYHRSL RNKALTKSIL
560 570 580 590 600
DDIQGIGEKR KKSLLNHFKD VDAIKKATME ELLEVDGMNK SIADNVYNFF

RKEEN
Length:605
Mass (Da):70,356
Last modified:July 25, 2006 - v1
Checksum:iF64DD341F6EB7924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70313.1.
RefSeqiWP_003436264.1. NZ_CP010905.1.
YP_001089930.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ70313; CAJ70313; CD630_34100.
GeneIDi4915787.
KEGGicdf:CD630_34100.
pdc:CDIF630_03715.
PATRICi19445379. VBICloDif38397_3573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70313.1.
RefSeqiWP_003436264.1. NZ_CP010905.1.
YP_001089930.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ180Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ70313; CAJ70313; CD630_34100.
GeneIDi4915787.
KEGGicdf:CD630_34100.
pdc:CDIF630_03715.
PATRICi19445379. VBICloDif38397_3573.

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3664-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRC_PEPD6
AccessioniPrimary (citable) accession number: Q180Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.