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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 37C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi117 – 124ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3471-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:CD630_33040
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000979421 – 416ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST416

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272563.CD3304

Structurei

3D structure databases

ProteinModelPortaliQ180E8
SMRiQ180E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 37C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN Bacteria
COG1219 LUCA
HOGENOMiHOG000010093
KOiK03544
OMAiDIMYDLP

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175 ClpX, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004487 Clp_protease_ATP-bd_su_ClpX
IPR027417 P-loop_NTPase
IPR010603 Znf_CppX_C4
IPR038366 Znf_CppX_C4_sf
PANTHERiPTHR11262 PTHR11262, 2 hits
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
PF06689 zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SM00994 zf-C4_ClpX, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00382 clpX, 1 hit

Sequencei

Sequence statusi: Complete.

Q180E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKYEEKRQL KCSFCGKNQD QVRRLIAGPN VYICDECVEL CDEIIQEEIE
60 70 80 90 100
DTIDEDTTSL PKPKEMMEIL NDYVIGQEKA KKALSVAVYN HYKRIYSKKS
110 120 130 140 150
SSKDIEIQKS NILLLGPTGS GKTLLAQTLA RTLNVPFAMA DATSLTEAGY
160 170 180 190 200
VGEDVENILL KLIQAADFDI EKAERGIIYI DEIDKIARKS ENPSITRDVS
210 220 230 240 250
GEGVQQALLK ILEGTVANVP PQGGRKHPHQ EFLKIDTTNV LFILGGAFDG
260 270 280 290 300
LEKIIQKRGG DKTLGFGAKI ESKKELDLGK LYEKVLPEDL LKYGIIPEFI
310 320 330 340 350
GRIPVLATLE LLDEDALMQI LQEPKNALVK QYKKLLELDD VELEFEEGAL
360 370 380 390 400
RAIAKKAIER NTGARGLRSI VESVMMETMF EVPSRDNIKK VIVTEKSVNE
410
DSVNPIIVLK DQEESA
Length:416
Mass (Da):46,471
Last modified:July 25, 2006 - v1
Checksum:i645CA347AE9CF8B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ70201.1
RefSeqiWP_003417105.1, NZ_CP010905.2
YP_001089820.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ70201; CAJ70201; CD630_33040
GeneIDi31354924
4912914
KEGGicdf:CD630_33040
pdc:CDIF630_03605
PATRICifig|272563.120.peg.3489

Similar proteinsi

Entry informationi

Entry nameiCLPX_PEPD6
AccessioniPrimary (citable) accession number: Q180E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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