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Protein
Submitted name:

Two-component response regulator

Gene

CD630_32650

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation, Two-component regulatory systemSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3509-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Two-component response regulatorImported
Gene namesi
Ordered Locus Names:CD630_32650Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi272563.CD3265.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QZJX-ray2.89A/B/C/D/E/F2-126[»]
ProteinModelPortaliQ180B0.
SMRiQ180B0. Positions 2-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ180B0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 117114Response regulatoryInterPro annotationAdd
BLAST
Domaini126 – 225100OmpR/PhoB-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains OmpR/PhoB-type DNA-binding domain.SAAS annotation
Contains response regulatory domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0745. LUCA.
HOGENOMiHOG000034819.
OMAiYHTELIY.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q180B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTKILIIDG DKDNCQKLKG FLEEKGISID LAYNCEEAIG KIFSNKYDLI
60 70 80 90 100
FLEIILSDGD GWTLCKKIRN VTTCPIVYMT YINEDQSILN ALNSGGDDYL
110 120 130 140 150
IKPLNLEILY AKVKAILRRM NSYVNNNENN TKLEEYNRTS GVIKLEDKII
160 170 180 190 200
KLTPTENKLL NFFIENPEKT LTTKEIYEHV WMNEYLEDNY SVVVAVNGLR
210 220
KKIEKDYKNP QKIITIRGAG YYFNKE
Length:226
Mass (Da):26,204
Last modified:July 25, 2006 - v1
Checksum:iB7FA915E8674F0BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70162.1.
RefSeqiWP_003432361.1. NZ_CP010905.1.
YP_001089781.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ70162; CAJ70162; CD630_32650.
GeneIDi4915689.
KEGGicdf:CD630_32650.
pdc:CDIF630_03564.
PATRICi19445069. VBICloDif38397_3418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70162.1.
RefSeqiWP_003432361.1. NZ_CP010905.1.
YP_001089781.1. NC_009089.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QZJX-ray2.89A/B/C/D/E/F2-126[»]
ProteinModelPortaliQ180B0.
SMRiQ180B0. Positions 2-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ70162; CAJ70162; CD630_32650.
GeneIDi4915689.
KEGGicdf:CD630_32650.
pdc:CDIF630_03564.
PATRICi19445069. VBICloDif38397_3418.

Phylogenomic databases

eggNOGiCOG0745. LUCA.
HOGENOMiHOG000034819.
OMAiYHTELIY.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3509-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ180B0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630Imported.
  2. "Crystal structure of a two-component response regulator from Clostridium difficile."
    Sugadev R., Burley S.K., Swaminathan S.
    Submitted (AUG-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 2-126.

Entry informationi

Entry nameiQ180B0_PEPD6
AccessioniPrimary (citable) accession number: Q180B0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.