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Q18081

- UGT48_CAEEL

UniProt

Q18081 - UGT48_CAEEL

Protein

Putative UDP-glucuronosyltransferase ugt-48

Gene

ugt-48

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative UDP-glucuronosyltransferase ugt-48 (EC:2.4.1.17)
    Short name:
    UDPGT 48
    Gene namesi
    Name:ugt-48
    Synonyms:ugt15
    ORF Names:C18C4.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiC18C4.3; CE38487; WBGene00015965; ugt-48.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 526509Putative UDP-glucuronosyltransferase ugt-48PRO_0000036054Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ18081.

    Interactioni

    Protein-protein interaction databases

    BioGridi43989. 2 interactions.
    MINTiMINT-1047334.
    STRINGi6239.C18C4.3.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ18081.
    SMRiQ18081. Positions 227-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei489 – 50921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320140.
    GeneTreeiENSGT00740000115714.
    HOGENOMiHOG000018977.
    InParanoidiQ18081.
    KOiK00699.
    OMAiHEVVNFE.
    OrthoDBiEOG7FJH06.
    PhylomeDBiQ18081.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q18081-1 [UniParc]FASTAAdd to Basket

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    MLLRILTFLA VCQVTTSHKI LMFSPTASKS HMISQGRIAD ELANAGHEVV    50
    NFEPDFLNLT DKFVPCKKCR RWPVTGLNNY KFKKIQNGLS GDVFQQSSIW 100
    SKIFNTDSDP YQDEYTNMCE EMVTNKELIE KLKKEKFDAY FGEQIHLCGM 150
    GLAHLIGIKH RFWIASCTMS VSMRDSLGIP TPSSLIPFMS TLDATPAPFW 200
    QRAKNFVLQM AHIRDEYRDV VLTNDMFKKN FGSDFPCVEF LAKTSDLIFV 250
    STDELLEIQA PTLSNVVHIG GLGLSSEGGG LDEKFVKIME KGKGVILFSL 300
    GTIANTTNLP PTIMENLMKI TQKFKDYEFI IKVDKFDRRS FDLAEGLSNV 350
    LVVDWVPQTA VLAHPRLKAF ITHAGYNSLM ESAYAGVPVI LIPFMFDQPR 400
    NGRSVERKGW GILRDRFQLI KDPDAIEGAI KEILVNPTYQ EKANRLKKLM 450
    RSKPQSASER LVKMTNWVLE NDGVEELQYE GKHMDFFTFY NLDIIITAAS 500
    IPVLIFIVLR ISNISIITSS PKNKKD 526
    Length:526
    Mass (Da):59,627
    Last modified:March 21, 2006 - v3
    Checksum:iC291099EE08F9FB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080608 Genomic DNA. Translation: CCD65106.1.
    RefSeqiNP_504464.2. NM_072063.5.
    UniGeneiCel.23456.

    Genome annotation databases

    EnsemblMetazoaiC18C4.3.1; C18C4.3.1; WBGene00015965.
    C18C4.3.2; C18C4.3.2; WBGene00015965.
    GeneIDi178940.
    KEGGicel:CELE_C18C4.3.
    UCSCiC18C4.3.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080608 Genomic DNA. Translation: CCD65106.1 .
    RefSeqi NP_504464.2. NM_072063.5.
    UniGenei Cel.23456.

    3D structure databases

    ProteinModelPortali Q18081.
    SMRi Q18081. Positions 227-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 43989. 2 interactions.
    MINTi MINT-1047334.
    STRINGi 6239.C18C4.3.1.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q18081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C18C4.3.1 ; C18C4.3.1 ; WBGene00015965 .
    C18C4.3.2 ; C18C4.3.2 ; WBGene00015965 .
    GeneIDi 178940.
    KEGGi cel:CELE_C18C4.3.
    UCSCi C18C4.3.1. c. elegans.

    Organism-specific databases

    CTDi 178940.
    WormBasei C18C4.3 ; CE38487 ; WBGene00015965 ; ugt-48.

    Phylogenomic databases

    eggNOGi NOG320140.
    GeneTreei ENSGT00740000115714.
    HOGENOMi HOG000018977.
    InParanoidi Q18081.
    KOi K00699.
    OMAi HEVVNFE.
    OrthoDBi EOG7FJH06.
    PhylomeDBi Q18081.

    Miscellaneous databases

    NextBioi 903208.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
      Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
      Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUGT48_CAEEL
    AccessioniPrimary (citable) accession number: Q18081
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3