Q18081 (UGT48_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative UDP-glucuronosyltransferase ugt-48
Short name=UDPGT 48
EC=2.4.1.17

Gene names

Name:	ugt-48
Synonyms:	ugt15
ORF Names:	C18C4.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 526	509	Putative UDP-glucuronosyltransferase ugt-48		PRO_0000036054
Regions
	Transmembrane	489 – 509	21	Helical; Potential
Amino acid modifications
	Glycosylation	58	1	N-linked (GlcNAc...) Ref.2
	Glycosylation	305	1	N-linked (GlcNAc...) Potential
	Glycosylation	513	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q18081 [UniParc]. Last modified March 21, 2006. Version 3. Checksum: C291099EE08F9FB5	FASTA	526	59,627
	10 20 30 40 50 60 MLLRILTFLA VCQVTTSHKI LMFSPTASKS HMISQGRIAD ELANAGHEVV NFEPDFLNLT 70 80 90 100 110 120 DKFVPCKKCR RWPVTGLNNY KFKKIQNGLS GDVFQQSSIW SKIFNTDSDP YQDEYTNMCE 130 140 150 160 170 180 EMVTNKELIE KLKKEKFDAY FGEQIHLCGM GLAHLIGIKH RFWIASCTMS VSMRDSLGIP 190 200 210 220 230 240 TPSSLIPFMS TLDATPAPFW QRAKNFVLQM AHIRDEYRDV VLTNDMFKKN FGSDFPCVEF 250 260 270 280 290 300 LAKTSDLIFV STDELLEIQA PTLSNVVHIG GLGLSSEGGG LDEKFVKIME KGKGVILFSL 310 320 330 340 350 360 GTIANTTNLP PTIMENLMKI TQKFKDYEFI IKVDKFDRRS FDLAEGLSNV LVVDWVPQTA 370 380 390 400 410 420 VLAHPRLKAF ITHAGYNSLM ESAYAGVPVI LIPFMFDQPR NGRSVERKGW GILRDRFQLI 430 440 450 460 470 480 KDPDAIEGAI KEILVNPTYQ EKANRLKKLM RSKPQSASER LVKMTNWVLE NDGVEELQYE 490 500 510 520 GKHMDFFTFY NLDIIITAAS IPVLIFIVLR ISNISIITSS PKNKKD

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins." Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T. Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed: 17761667] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58, MASS SPECTROMETRY. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080608 Genomic DNA. Translation: CCD65106.1.
RefSeq	NP_504464.2. NM_072063.4.
UniGene	Cel.23456.
3D structure databases
ProteinModelPortal	Q18081.
SMR	Q18081. Positions 29-55, 279-452.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1047334.
STRING	Q18081.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C18C4.3.1; C18C4.3.1; C18C4.3. C18C4.3.2; C18C4.3.2; C18C4.3. C18C4.3.3; C18C4.3.3; C18C4.3.
GeneID	178940.
KEGG	cel:C18C4.3.
UCSC	C18C4.3.1. c. elegans.
Organism-specific databases
CTD	178940.
WormBase	C18C4.3; CE38487; WBGene00015965; ugt-48.
Phylogenomic databases
eggNOG	meNOG23463.
GeneTree	EMGT00070000025718.
HOGENOM	HBG385940.
InParanoid	Q18081.
OMA	MAHIRDE.
PhylomeDB	Q18081.
Gene expression databases
ArrayExpress	Q18081.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
KO	K00699.
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	903208.

Entry information

Entry name

UGT48_CAEEL

Accession

Primary (citable) accession number: Q18081

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 21, 2006
Last modified:	December 14, 2011
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project