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Protein

Putative UDP-glucuronosyltransferase ugt-48

Gene

ugt-48

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucuronosyltransferase ugt-48 (EC:2.4.1.17)
Short name:
UDPGT 48
Gene namesi
Name:ugt-48
Synonyms:ugt15
ORF Names:C18C4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC18C4.3; CE38487; WBGene00015965; ugt-48.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 526509Putative UDP-glucuronosyltransferase ugt-48PRO_0000036054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ18081.

Interactioni

Protein-protein interaction databases

BioGridi43989. 2 interactions.
MINTiMINT-1047334.
STRINGi6239.C18C4.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ18081.
SMRiQ18081. Positions 227-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320140.
GeneTreeiENSGT00770000120743.
HOGENOMiHOG000018977.
InParanoidiQ18081.
KOiK00699.
OMAiQMAHIRD.
OrthoDBiEOG7FJH06.
PhylomeDBiQ18081.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRILTFLA VCQVTTSHKI LMFSPTASKS HMISQGRIAD ELANAGHEVV
60 70 80 90 100
NFEPDFLNLT DKFVPCKKCR RWPVTGLNNY KFKKIQNGLS GDVFQQSSIW
110 120 130 140 150
SKIFNTDSDP YQDEYTNMCE EMVTNKELIE KLKKEKFDAY FGEQIHLCGM
160 170 180 190 200
GLAHLIGIKH RFWIASCTMS VSMRDSLGIP TPSSLIPFMS TLDATPAPFW
210 220 230 240 250
QRAKNFVLQM AHIRDEYRDV VLTNDMFKKN FGSDFPCVEF LAKTSDLIFV
260 270 280 290 300
STDELLEIQA PTLSNVVHIG GLGLSSEGGG LDEKFVKIME KGKGVILFSL
310 320 330 340 350
GTIANTTNLP PTIMENLMKI TQKFKDYEFI IKVDKFDRRS FDLAEGLSNV
360 370 380 390 400
LVVDWVPQTA VLAHPRLKAF ITHAGYNSLM ESAYAGVPVI LIPFMFDQPR
410 420 430 440 450
NGRSVERKGW GILRDRFQLI KDPDAIEGAI KEILVNPTYQ EKANRLKKLM
460 470 480 490 500
RSKPQSASER LVKMTNWVLE NDGVEELQYE GKHMDFFTFY NLDIIITAAS
510 520
IPVLIFIVLR ISNISIITSS PKNKKD
Length:526
Mass (Da):59,627
Last modified:March 21, 2006 - v3
Checksum:iC291099EE08F9FB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080608 Genomic DNA. Translation: CCD65106.1.
RefSeqiNP_504464.2. NM_072063.5.
UniGeneiCel.23456.

Genome annotation databases

EnsemblMetazoaiC18C4.3.1; C18C4.3.1; WBGene00015965.
C18C4.3.2; C18C4.3.2; WBGene00015965.
GeneIDi178940.
KEGGicel:CELE_C18C4.3.
UCSCiC18C4.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080608 Genomic DNA. Translation: CCD65106.1.
RefSeqiNP_504464.2. NM_072063.5.
UniGeneiCel.23456.

3D structure databases

ProteinModelPortaliQ18081.
SMRiQ18081. Positions 227-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43989. 2 interactions.
MINTiMINT-1047334.
STRINGi6239.C18C4.3.1.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbiQ18081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC18C4.3.1; C18C4.3.1; WBGene00015965.
C18C4.3.2; C18C4.3.2; WBGene00015965.
GeneIDi178940.
KEGGicel:CELE_C18C4.3.
UCSCiC18C4.3.1. c. elegans.

Organism-specific databases

CTDi178940.
WormBaseiC18C4.3; CE38487; WBGene00015965; ugt-48.

Phylogenomic databases

eggNOGiNOG320140.
GeneTreeiENSGT00770000120743.
HOGENOMiHOG000018977.
InParanoidiQ18081.
KOiK00699.
OMAiQMAHIRD.
OrthoDBiEOG7FJH06.
PhylomeDBiQ18081.

Miscellaneous databases

NextBioi903208.
PROiQ18081.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiUGT48_CAEEL
AccessioniPrimary (citable) accession number: Q18081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: June 24, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.