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Q18081 (UGT48_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative UDP-glucuronosyltransferase ugt-48

Short name=UDPGT 48
EC=2.4.1.17
Gene names
Name:ugt-48
Synonyms:ugt15
ORF Names:C18C4.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 526509Putative UDP-glucuronosyltransferase ugt-48
PRO_0000036054

Regions

Transmembrane489 – 50921Helical; Potential

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Ref.2
Glycosylation3051N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q18081 [UniParc].

Last modified March 21, 2006. Version 3.
Checksum: C291099EE08F9FB5

FASTA52659,627
        10         20         30         40         50         60 
MLLRILTFLA VCQVTTSHKI LMFSPTASKS HMISQGRIAD ELANAGHEVV NFEPDFLNLT 

        70         80         90        100        110        120 
DKFVPCKKCR RWPVTGLNNY KFKKIQNGLS GDVFQQSSIW SKIFNTDSDP YQDEYTNMCE 

       130        140        150        160        170        180 
EMVTNKELIE KLKKEKFDAY FGEQIHLCGM GLAHLIGIKH RFWIASCTMS VSMRDSLGIP 

       190        200        210        220        230        240 
TPSSLIPFMS TLDATPAPFW QRAKNFVLQM AHIRDEYRDV VLTNDMFKKN FGSDFPCVEF 

       250        260        270        280        290        300 
LAKTSDLIFV STDELLEIQA PTLSNVVHIG GLGLSSEGGG LDEKFVKIME KGKGVILFSL 

       310        320        330        340        350        360 
GTIANTTNLP PTIMENLMKI TQKFKDYEFI IKVDKFDRRS FDLAEGLSNV LVVDWVPQTA 

       370        380        390        400        410        420 
VLAHPRLKAF ITHAGYNSLM ESAYAGVPVI LIPFMFDQPR NGRSVERKGW GILRDRFQLI 

       430        440        450        460        470        480 
KDPDAIEGAI KEILVNPTYQ EKANRLKKLM RSKPQSASER LVKMTNWVLE NDGVEELQYE 

       490        500        510        520 
GKHMDFFTFY NLDIIITAAS IPVLIFIVLR ISNISIITSS PKNKKD 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080608 Genomic DNA. Translation: CCD65106.1.
RefSeqNP_504464.2. NM_072063.5.
UniGeneCel.23456.

3D structure databases

ProteinModelPortalQ18081.
SMRQ18081. Positions 227-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid43989. 2 interactions.
MINTMINT-1047334.
STRING6239.C18C4.3.1.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbQ18081.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC18C4.3.1; C18C4.3.1; WBGene00015965.
C18C4.3.2; C18C4.3.2; WBGene00015965.
GeneID178940.
KEGGcel:CELE_C18C4.3.
UCSCC18C4.3.1. c. elegans.

Organism-specific databases

CTD178940.
WormBaseC18C4.3; CE38487; WBGene00015965; ugt-48.

Phylogenomic databases

eggNOGNOG320140.
GeneTreeENSGT00740000115714.
HOGENOMHOG000018977.
InParanoidQ18081.
KOK00699.
OMAHEVVNFE.
OrthoDBEOG7FJH06.
PhylomeDBQ18081.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio903208.

Entry information

Entry nameUGT48_CAEEL
AccessionPrimary (citable) accession number: Q18081
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase