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Q18081

- UGT48_CAEEL

UniProt

Q18081 - UGT48_CAEEL

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Protein
Putative UDP-glucuronosyltransferase ugt-48
Gene
ugt-48, ugt15, C18C4.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucuronosyltransferase ugt-48 (EC:2.4.1.17)
Short name:
UDPGT 48
Gene namesi
Name:ugt-48
Synonyms:ugt15
ORF Names:C18C4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiC18C4.3; CE38487; WBGene00015965; ugt-48.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 526509Putative UDP-glucuronosyltransferase ugt-48
PRO_0000036054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ18081.

Interactioni

Protein-protein interaction databases

BioGridi43989. 2 interactions.
MINTiMINT-1047334.
STRINGi6239.C18C4.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ18081.
SMRiQ18081. Positions 227-449.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320140.
GeneTreeiENSGT00740000115714.
HOGENOMiHOG000018977.
InParanoidiQ18081.
KOiK00699.
OMAiHEVVNFE.
OrthoDBiEOG7FJH06.
PhylomeDBiQ18081.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18081-1 [UniParc]FASTAAdd to Basket

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MLLRILTFLA VCQVTTSHKI LMFSPTASKS HMISQGRIAD ELANAGHEVV    50
NFEPDFLNLT DKFVPCKKCR RWPVTGLNNY KFKKIQNGLS GDVFQQSSIW 100
SKIFNTDSDP YQDEYTNMCE EMVTNKELIE KLKKEKFDAY FGEQIHLCGM 150
GLAHLIGIKH RFWIASCTMS VSMRDSLGIP TPSSLIPFMS TLDATPAPFW 200
QRAKNFVLQM AHIRDEYRDV VLTNDMFKKN FGSDFPCVEF LAKTSDLIFV 250
STDELLEIQA PTLSNVVHIG GLGLSSEGGG LDEKFVKIME KGKGVILFSL 300
GTIANTTNLP PTIMENLMKI TQKFKDYEFI IKVDKFDRRS FDLAEGLSNV 350
LVVDWVPQTA VLAHPRLKAF ITHAGYNSLM ESAYAGVPVI LIPFMFDQPR 400
NGRSVERKGW GILRDRFQLI KDPDAIEGAI KEILVNPTYQ EKANRLKKLM 450
RSKPQSASER LVKMTNWVLE NDGVEELQYE GKHMDFFTFY NLDIIITAAS 500
IPVLIFIVLR ISNISIITSS PKNKKD 526
Length:526
Mass (Da):59,627
Last modified:March 21, 2006 - v3
Checksum:iC291099EE08F9FB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080608 Genomic DNA. Translation: CCD65106.1.
RefSeqiNP_504464.2. NM_072063.5.
UniGeneiCel.23456.

Genome annotation databases

EnsemblMetazoaiC18C4.3.1; C18C4.3.1; WBGene00015965.
C18C4.3.2; C18C4.3.2; WBGene00015965.
GeneIDi178940.
KEGGicel:CELE_C18C4.3.
UCSCiC18C4.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080608 Genomic DNA. Translation: CCD65106.1 .
RefSeqi NP_504464.2. NM_072063.5.
UniGenei Cel.23456.

3D structure databases

ProteinModelPortali Q18081.
SMRi Q18081. Positions 227-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 43989. 2 interactions.
MINTi MINT-1047334.
STRINGi 6239.C18C4.3.1.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi Q18081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C18C4.3.1 ; C18C4.3.1 ; WBGene00015965 .
C18C4.3.2 ; C18C4.3.2 ; WBGene00015965 .
GeneIDi 178940.
KEGGi cel:CELE_C18C4.3.
UCSCi C18C4.3.1. c. elegans.

Organism-specific databases

CTDi 178940.
WormBasei C18C4.3 ; CE38487 ; WBGene00015965 ; ugt-48.

Phylogenomic databases

eggNOGi NOG320140.
GeneTreei ENSGT00740000115714.
HOGENOMi HOG000018977.
InParanoidi Q18081.
KOi K00699.
OMAi HEVVNFE.
OrthoDBi EOG7FJH06.
PhylomeDBi Q18081.

Miscellaneous databases

NextBioi 903208.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiUGT48_CAEEL
AccessioniPrimary (citable) accession number: Q18081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi