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Q17ZY4

- PRAC_PEPD6

UniProt

Q17ZY4 - PRAC_PEPD6

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Protein
Proline racemase
Gene
CD630_32370
Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways By similarity.

Catalytic activityi

L-proline = D-proline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911Proton acceptor By similarity
Active sitei255 – 2551Proton donor By similarity

GO - Molecular functioni

  1. proline racemase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciCDIF272563:GJFE-3480-MONOMER.
    BRENDAi5.1.1.4. 1473.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline racemase (EC:5.1.1.4)
    Gene namesi
    Ordered Locus Names:CD630_32370
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Proline racemase
    PRO_0000354023Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.

    Protein-protein interaction databases

    STRINGi272563.CD3237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17ZY4.
    SMRiQ17ZY4. Positions 3-335.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the proline racemase family.

    Phylogenomic databases

    eggNOGiCOG3938.
    HOGENOMiHOG000084336.
    KOiK01777.
    OMAiWIRQALM.
    OrthoDBiEOG6SNDV3.

    Family and domain databases

    InterProiIPR008794. Pro_racemase_fam.
    [Graphical view]
    PfamiPF05544. Pro_racemase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF029792. Pro_racemase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q17ZY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFSRSIQAI DSHTAGEATR IVVGGIPNIK GNSMPEKKEY LEENLDYLRT    50
    AIMLEPRGHN DMFGSVMTQP CCPDADFGII FMDGGGYLNM CGHGTIGAMT 100
    AAIETGVVPA VEPVTHVVME APAGIIRGDV TVVDGKAKEV SFLNVPAFLY 150
    KEGVEVDLPG VGTVKFDISF GGSFFAIIHA SQLGLKIEPQ NAGKLTELAM 200
    KLRDIINEKI EIQHPTLAHI KTVDLVEIYD EPTHPEATYK NVVIFGQGQV 250
    DRSPCGTGTS AKLATLHAKG ELKVGEKFVY ESILGTLFKG EIVEETKVAD 300
    FNAVVPKITG SAYITGFNHF VIDEEDPLKH GFILK 335
    Length:335
    Mass (Da):36,221
    Last modified:July 25, 2006 - v1
    Checksum:iC1C7BD9E6E3FAB86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ70135.1.
    RefSeqiYP_001089754.1. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ70135; CAJ70135; CD630_32370.
    GeneIDi4916393.
    KEGGicdf:CD630_32370.
    PATRICi19445013. VBICloDif38397_3390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ70135.1 .
    RefSeqi YP_001089754.1. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q17ZY4.
    SMRi Q17ZY4. Positions 3-335.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272563.CD3237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ70135 ; CAJ70135 ; CD630_32370 .
    GeneIDi 4916393.
    KEGGi cdf:CD630_32370.
    PATRICi 19445013. VBICloDif38397_3390.

    Phylogenomic databases

    eggNOGi COG3938.
    HOGENOMi HOG000084336.
    KOi K01777.
    OMAi WIRQALM.
    OrthoDBi EOG6SNDV3.

    Enzyme and pathway databases

    BioCyci CDIF272563:GJFE-3480-MONOMER.
    BRENDAi 5.1.1.4. 1473.

    Family and domain databases

    InterProi IPR008794. Pro_racemase_fam.
    [Graphical view ]
    Pfami PF05544. Pro_racemase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF029792. Pro_racemase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630.

    Entry informationi

    Entry nameiPRAC_PEPD6
    AccessioniPrimary (citable) accession number: Q17ZY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: July 25, 2006
    Last modified: June 11, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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