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Protein

Proline racemase

Gene

CD630_32370

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways (By similarity).By similarity

Catalytic activityi

L-proline = D-proline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911Proton acceptorBy similarity
Active sitei255 – 2551Proton donorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3480-MONOMER.
BRENDAi5.1.1.4. 1473.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline racemase (EC:5.1.1.4)
Gene namesi
Ordered Locus Names:CD630_32370
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Proline racemasePRO_0000354023Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272563.CD3237.

Structurei

3D structure databases

ProteinModelPortaliQ17ZY4.
SMRiQ17ZY4. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proline racemase family.Curated

Phylogenomic databases

eggNOGiCOG3938.
HOGENOMiHOG000084336.
KOiK01777.
OMAiCPCGLVT.
OrthoDBiEOG6SNDV3.

Family and domain databases

InterProiIPR008794. Pro_racemase_fam.
[Graphical view]
PfamiPF05544. Pro_racemase. 1 hit.
[Graphical view]
PIRSFiPIRSF029792. Pro_racemase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17ZY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSRSIQAI DSHTAGEATR IVVGGIPNIK GNSMPEKKEY LEENLDYLRT
60 70 80 90 100
AIMLEPRGHN DMFGSVMTQP CCPDADFGII FMDGGGYLNM CGHGTIGAMT
110 120 130 140 150
AAIETGVVPA VEPVTHVVME APAGIIRGDV TVVDGKAKEV SFLNVPAFLY
160 170 180 190 200
KEGVEVDLPG VGTVKFDISF GGSFFAIIHA SQLGLKIEPQ NAGKLTELAM
210 220 230 240 250
KLRDIINEKI EIQHPTLAHI KTVDLVEIYD EPTHPEATYK NVVIFGQGQV
260 270 280 290 300
DRSPCGTGTS AKLATLHAKG ELKVGEKFVY ESILGTLFKG EIVEETKVAD
310 320 330
FNAVVPKITG SAYITGFNHF VIDEEDPLKH GFILK
Length:335
Mass (Da):36,221
Last modified:July 25, 2006 - v1
Checksum:iC1C7BD9E6E3FAB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70135.1.
RefSeqiWP_003422090.1. NC_009089.1.
YP_001089754.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ70135; CAJ70135; CD630_32370.
GeneIDi4916393.
KEGGicdf:CD630_32370.
PATRICi19445013. VBICloDif38397_3390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ70135.1.
RefSeqiWP_003422090.1. NC_009089.1.
YP_001089754.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ17ZY4.
SMRiQ17ZY4. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ70135; CAJ70135; CD630_32370.
GeneIDi4916393.
KEGGicdf:CD630_32370.
PATRICi19445013. VBICloDif38397_3390.

Phylogenomic databases

eggNOGiCOG3938.
HOGENOMiHOG000084336.
KOiK01777.
OMAiCPCGLVT.
OrthoDBiEOG6SNDV3.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3480-MONOMER.
BRENDAi5.1.1.4. 1473.

Family and domain databases

InterProiIPR008794. Pro_racemase_fam.
[Graphical view]
PfamiPF05544. Pro_racemase. 1 hit.
[Graphical view]
PIRSFiPIRSF029792. Pro_racemase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiPRAC_PEPD6
AccessioniPrimary (citable) accession number: Q17ZY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 25, 2006
Last modified: May 27, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.