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Q17ZP4

- Q17ZP4_HELAH

UniProt

Q17ZP4 - Q17ZP4_HELAH

Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotationSAAS annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHACI382638:GJAU-14-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpBUniRule annotationImported
    Ordered Locus Names:Hac_0014Imported
    OrganismiHelicobacter acinonychis (strain Sheeba)Imported
    Taxonomic identifieri382638 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000775: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei85 – 851N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi382638.Hac_0014.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17ZP4.
    SMRiQ17ZP4. Positions 6-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0133.
    HOGENOMiHOG000161710.
    KOiK01696.
    OMAiEFMTLLQ.
    OrthoDBiEOG6GFGH7.

    Family and domain databases

    HAMAPiMF_00133. Trp_synth_beta.
    InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view]
    PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00263. trpB. 1 hit.
    PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17ZP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKAYFGEF GGSFVSELLV PALRELEQAF DACLKDDKFQ QEYFHLLKDF    50
    VGRPSPLTLC QNIISNPKVR LYLKREDLIH GGAHKTNQAL GQALLAKKMG 100
    KTRIIAETGA GQHGVATAIA CALLNLKCVI FMGGKDIKRQ EMNVFRMRLL 150
    GAEIREVNSG SATLKDAVNE TLRDWASSYK DTHYLLGTAA GPHPYPTMVK 200
    TFQKMIGDEA KQQILEKENR LPDYVIACVG GGSNAIGIFS AFLNDKEVKL 250
    IGVEPAGLGL ETNKHGATLN KGRVGILHGN KTYLLQDDEG QIIESHSISA 300
    GLDYPGVGPE HSFLKESGRA IYESASDIEA LEAFSLLCQK EGIIPALESS 350
    HALAYALKLA QKCTQESIIV VNLSGRGDKD LNTVYSALKG DLK 393
    Length:393
    Mass (Da):42,823
    Last modified:July 25, 2006 - v1
    Checksum:iA7055F1D40481169
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAJ98882.1.
    RefSeqiYP_663881.1. NC_008229.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ98882; CAJ98882; Hac_0014.
    GeneIDi4177493.
    KEGGihac:Hac_0014.
    PATRICi20583960. VBIHelAci71660_0014.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAJ98882.1 .
    RefSeqi YP_663881.1. NC_008229.1.

    3D structure databases

    ProteinModelPortali Q17ZP4.
    SMRi Q17ZP4. Positions 6-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382638.Hac_0014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ98882 ; CAJ98882 ; Hac_0014 .
    GeneIDi 4177493.
    KEGGi hac:Hac_0014.
    PATRICi 20583960. VBIHelAci71660_0014.

    Phylogenomic databases

    eggNOGi COG0133.
    HOGENOMi HOG000161710.
    KOi K01696.
    OMAi EFMTLLQ.
    OrthoDBi EOG6GFGH7.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci HACI382638:GJAU-14-MONOMER.

    Family and domain databases

    HAMAPi MF_00133. Trp_synth_beta.
    InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view ]
    PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00263. trpB. 1 hit.
    PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
      Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
      PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SheebaImported.

    Entry informationi

    Entry nameiQ17ZP4_HELAH
    AccessioniPrimary (citable) accession number: Q17ZP4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3