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Q17ZP4 (Q17ZP4_HELAH) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity. HAMAP-Rule MF_00133 SAAS SAAS006654

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00133 SAAS SAAS006654

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00133 SAAS SAAS006654

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00133 SAAS SAAS006654

Subunit structure

Tetramer of two alpha and two beta chains By similarity. HAMAP-Rule MF_00133 SAAS SAAS006654

Sequence similarities

Belongs to the TrpB family. HAMAP-Rule MF_00133

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue851N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00133

Sequences

Sequence LengthMass (Da)Tools
Q17ZP4 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: A7055F1D40481169

FASTA39342,823
        10         20         30         40         50         60 
MNKKAYFGEF GGSFVSELLV PALRELEQAF DACLKDDKFQ QEYFHLLKDF VGRPSPLTLC 

        70         80         90        100        110        120 
QNIISNPKVR LYLKREDLIH GGAHKTNQAL GQALLAKKMG KTRIIAETGA GQHGVATAIA 

       130        140        150        160        170        180 
CALLNLKCVI FMGGKDIKRQ EMNVFRMRLL GAEIREVNSG SATLKDAVNE TLRDWASSYK 

       190        200        210        220        230        240 
DTHYLLGTAA GPHPYPTMVK TFQKMIGDEA KQQILEKENR LPDYVIACVG GGSNAIGIFS 

       250        260        270        280        290        300 
AFLNDKEVKL IGVEPAGLGL ETNKHGATLN KGRVGILHGN KTYLLQDDEG QIIESHSISA 

       310        320        330        340        350        360 
GLDYPGVGPE HSFLKESGRA IYESASDIEA LEAFSLLCQK EGIIPALESS HALAYALKLA 

       370        380        390 
QKCTQESIIV VNLSGRGDKD LNTVYSALKG DLK 

« Hide

References

[1]"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sheeba EMBL CAJ98882.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260522 Genomic DNA. Translation: CAJ98882.1.
RefSeqYP_663881.1. NC_008229.1.

3D structure databases

ProteinModelPortalQ17ZP4.
SMRQ17ZP4. Positions 6-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382638.Hac_0014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ98882; CAJ98882; Hac_0014.
GeneID4177493.
KEGGhac:Hac_0014.
PATRIC20583960. VBIHelAci71660_0014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0133.
HOGENOMHOG000161710.
KOK01696.
OMAEFMTLLQ.
OrthoDBEOG6GFGH7.

Enzyme and pathway databases

BioCycHACI382638:GJAU-14-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

HAMAPMF_00133. Trp_synth_beta.
InterProIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00263. trpB. 1 hit.
PROSITEPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ17ZP4_HELAH
AccessionPrimary (citable) accession number: Q17ZP4
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)