Q17ZP4 (Q17ZP4_HELAH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tryptophan synthase beta chain HAMAP-Rule MF_00133
EC=4.2.1.20 HAMAP-Rule MF_00133

Gene names

Name:	trpB HAMAP-Rule MF_00133 EMBL CAJ98882.1
Ordered Locus Names:	Hac_0014 EMBL CAJ98882.1

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP] EMBL CAJ98882.1

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter acinonyx

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity. HAMAP-Rule MF_00133 SAAS SAAS006654
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00133 SAAS SAAS006654
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00133 SAAS SAAS006654
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00133 SAAS SAAS006654
Subunit structure	Tetramer of two alpha and two beta chains By similarity. HAMAP-Rule MF_00133 SAAS SAAS006654
Sequence similarities	Belongs to the TrpB family. HAMAP-Rule MF_00133

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis SAAS SAAS006654 HAMAP-Rule MF_00133
Ligand	Pyridoxal phosphate SAAS SAAS006654 HAMAP-Rule MF_00133 RuleBase RU003663
Molecular function	Lyase SAAS SAAS006654 HAMAP-Rule MF_00133 EMBL CAJ98882.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	tryptophan synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	85	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00133

Sequences

	Sequence		Length	Mass (Da)
	Q17ZP4 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: A7055F1D40481169	FASTA	393	42,823
	10 20 30 40 50 60 MNKKAYFGEF GGSFVSELLV PALRELEQAF DACLKDDKFQ QEYFHLLKDF VGRPSPLTLC 70 80 90 100 110 120 QNIISNPKVR LYLKREDLIH GGAHKTNQAL GQALLAKKMG KTRIIAETGA GQHGVATAIA 130 140 150 160 170 180 CALLNLKCVI FMGGKDIKRQ EMNVFRMRLL GAEIREVNSG SATLKDAVNE TLRDWASSYK 190 200 210 220 230 240 DTHYLLGTAA GPHPYPTMVK TFQKMIGDEA KQQILEKENR LPDYVIACVG GGSNAIGIFS 250 260 270 280 290 300 AFLNDKEVKL IGVEPAGLGL ETNKHGATLN KGRVGILHGN KTYLLQDDEG QIIESHSISA 310 320 330 340 350 360 GLDYPGVGPE HSFLKESGRA IYESASDIEA LEAFSLLCQK EGIIPALESS HALAYALKLA 370 380 390 QKCTQESIIV VNLSGRGDKD LNTVYSALKG DLK

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:e120-e120(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheeba EMBL CAJ98882.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260522 Genomic DNA. Translation: CAJ98882.1.
RefSeq	YP_663881.1. NC_008229.1.
3D structure databases
ProteinModelPortal	Q17ZP4.
SMR	Q17ZP4. Positions 6-390.
ModBase	Search...
Protein-protein interaction databases
STRING	382638.Hac_0014.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ98882; CAJ98882; Hac_0014.
GeneID	4177493.
KEGG	hac:Hac_0014.
PATRIC	20583960. VBIHelAci71660_0014.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0133.
HOGENOM	HOG000161710.
KO	K01696.
OMA	REDLCHT.
ProtClustDB	PRK04346.
Enzyme and pathway databases
BioCyc	HACI382638:GJAU-14-MONOMER.
UniPathway	UPA00035; UER00044.
Family and domain databases
HAMAP	MF_00133. Trp_synth_beta.
InterPro	IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. IPR006653. Trp_synth_b_CS. IPR006654. Trp_synth_beta. IPR023026. Trp_synth_beta/beta-like. [Graphical view]
PANTHER	PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00263. trpB. 1 hit.
PROSITE	PS00168. TRP_SYNTHASE_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q17ZP4_HELAH

Accession

Primary (citable) accession number: Q17ZP4

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)