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Q17ZP4

- Q17ZP4_HELAH

UniProt

Q17ZP4 - Q17ZP4_HELAH

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Protein
Tryptophan synthase beta chain
Gene
trpB, Hac_0014
Organism
Helicobacter acinonychis (strain Sheeba)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHACI382638:GJAU-14-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotationImported
Ordered Locus Names:Hac_0014Imported
OrganismiHelicobacter acinonychis (strain Sheeba)Imported
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi382638.Hac_0014.

Structurei

3D structure databases

ProteinModelPortaliQ17ZP4.
SMRiQ17ZP4. Positions 6-390.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0133.
HOGENOMiHOG000161710.
KOiK01696.
OMAiEFMTLLQ.
OrthoDBiEOG6GFGH7.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17ZP4-1 [UniParc]FASTAAdd to Basket

« Hide

MNKKAYFGEF GGSFVSELLV PALRELEQAF DACLKDDKFQ QEYFHLLKDF    50
VGRPSPLTLC QNIISNPKVR LYLKREDLIH GGAHKTNQAL GQALLAKKMG 100
KTRIIAETGA GQHGVATAIA CALLNLKCVI FMGGKDIKRQ EMNVFRMRLL 150
GAEIREVNSG SATLKDAVNE TLRDWASSYK DTHYLLGTAA GPHPYPTMVK 200
TFQKMIGDEA KQQILEKENR LPDYVIACVG GGSNAIGIFS AFLNDKEVKL 250
IGVEPAGLGL ETNKHGATLN KGRVGILHGN KTYLLQDDEG QIIESHSISA 300
GLDYPGVGPE HSFLKESGRA IYESASDIEA LEAFSLLCQK EGIIPALESS 350
HALAYALKLA QKCTQESIIV VNLSGRGDKD LNTVYSALKG DLK 393
Length:393
Mass (Da):42,823
Last modified:July 25, 2006 - v1
Checksum:iA7055F1D40481169
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ98882.1.
RefSeqiYP_663881.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAJ98882; CAJ98882; Hac_0014.
GeneIDi4177493.
KEGGihac:Hac_0014.
PATRICi20583960. VBIHelAci71660_0014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ98882.1 .
RefSeqi YP_663881.1. NC_008229.1.

3D structure databases

ProteinModelPortali Q17ZP4.
SMRi Q17ZP4. Positions 6-390.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382638.Hac_0014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ98882 ; CAJ98882 ; Hac_0014 .
GeneIDi 4177493.
KEGGi hac:Hac_0014.
PATRICi 20583960. VBIHelAci71660_0014.

Phylogenomic databases

eggNOGi COG0133.
HOGENOMi HOG000161710.
KOi K01696.
OMAi EFMTLLQ.
OrthoDBi EOG6GFGH7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .
BioCyci HACI382638:GJAU-14-MONOMER.

Family and domain databases

HAMAPi MF_00133. Trp_synth_beta.
InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view ]
PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00263. trpB. 1 hit.
PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SheebaImported.

Entry informationi

Entry nameiQ17ZP4_HELAH
AccessioniPrimary (citable) accession number: Q17ZP4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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