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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotationSAAS annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHACI382638:G1G1M-13-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotationImported
Ordered Locus Names:Hac_0014Imported
OrganismiHelicobacter acinonychis (strain Sheeba)Imported
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000775 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi382638.Hac_0014

Structurei

3D structure databases

ProteinModelPortaliQ17ZP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 375PALPInterPro annotationAdd BLAST324

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
KOiK01696
OMAiHGMKSYF
OrthoDBiPOG091H02JY

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q17ZP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKAYFGEF GGSFVSELLV PALRELEQAF DACLKDDKFQ QEYFHLLKDF
60 70 80 90 100
VGRPSPLTLC QNIISNPKVR LYLKREDLIH GGAHKTNQAL GQALLAKKMG
110 120 130 140 150
KTRIIAETGA GQHGVATAIA CALLNLKCVI FMGGKDIKRQ EMNVFRMRLL
160 170 180 190 200
GAEIREVNSG SATLKDAVNE TLRDWASSYK DTHYLLGTAA GPHPYPTMVK
210 220 230 240 250
TFQKMIGDEA KQQILEKENR LPDYVIACVG GGSNAIGIFS AFLNDKEVKL
260 270 280 290 300
IGVEPAGLGL ETNKHGATLN KGRVGILHGN KTYLLQDDEG QIIESHSISA
310 320 330 340 350
GLDYPGVGPE HSFLKESGRA IYESASDIEA LEAFSLLCQK EGIIPALESS
360 370 380 390
HALAYALKLA QKCTQESIIV VNLSGRGDKD LNTVYSALKG DLK
Length:393
Mass (Da):42,823
Last modified:July 25, 2006 - v1
Checksum:iA7055F1D40481169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA Translation: CAJ98882.1
RefSeqiWP_011577004.1, NC_008229.1

Genome annotation databases

EnsemblBacteriaiCAJ98882; CAJ98882; Hac_0014
GeneIDi31757572
KEGGihac:Hac_0014

Similar proteinsi

Entry informationi

Entry nameiQ17ZP4_HELAH
AccessioniPrimary (citable) accession number: Q17ZP4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health