Q17Z34 (AROE_HELAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Hac_0244

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021290
Regions
	Nucleotide binding	125 – 129	5	NADP By similarity
Sites
	Active site	69	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q17Z34 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 79AE7C094ECD38AA	FASTA	263	28,932
	10 20 30 40 50 60 MGLKSFGVLG NPIKHSKSPL IHNACFLTFQ KELGFLGHYH PILLPLESHI KNEFLNLGLS 70 80 90 100 110 120 GANVTLPFKE RAFQVCDKIK GIALECGAVN TLVLENDELV GYNTDALGFY LSLKQKNYQS 130 140 150 160 170 180 ALILGSGGSA KALACELKKR GLKVSVLNRS TKGLDFFQNL GCACFTTTPK GAFDLIINAT 190 200 210 220 230 240 SASLNNELPL DKEVLKGYFK ESRLAYDLAY GFLTPFLSLA KELKLPFQDG KGMLIYQASL 250 260 SFEKFSSSQI SYSKAFEIMR SVF

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheeba.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260522 Genomic DNA. Translation: CAJ99092.1.
RefSeq	YP_664091.1. NC_008229.1.
3D structure databases
ProteinModelPortal	Q17Z34.
ModBase	Search...
Protein-protein interaction databases
STRING	Q17Z34.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4176936.
GenomeReviews	Gene locus Hac_0244 in contig AM260522_GR.
KEGG	hac:Hac_0244.
NMPDR	fig|382638.8.peg.236.
PATRIC	20584421. VBIHelAci71660_0242.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	Q17Z34.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	HACI382638:HAC_0244-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_HELAH

Accession

Primary (citable) accession number: Q17Z34

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program