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Q17YZ0

- SYL_HELAH

UniProt

Q17YZ0 - SYL_HELAH

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Protein
Leucine--tRNA ligase
Gene
leuS, Hac_0293
Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHACI382638:GJAU-277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Hac_0293
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligaseUniRule annotation
PRO_0000334762Add
BLAST

Proteomic databases

PRIDEiQ17YZ0.

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_0293.

Structurei

3D structure databases

ProteinModelPortaliQ17YZ0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 4811"HIGH" regionUniRule annotation
Add
BLAST
Motifi572 – 5765"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17YZ0-1 [UniParc]FASTAAdd to Basket

« Hide

MDFVSIEKKW QEFWHQNESF EPKDDFNLPK KYILSMLPYP SGEIHMGHVR    50
NYTIGDALVR YYRLHHYNVL HPMGFDSFGM PAENAAIKHG IHPKTWTYEN 100
IENMQKEFEA LGFSFSKNRE FATSDPNYTE FEQQFFIDLW EKGLIYRKKA 150
MLNWCPNDKT VLANEQVIEG RCWRCDTEVV QKELYQYYLK ITNYAEELLK 200
DLETLKNHWP SQVLLMQKNW IGKSSGLQFR FKIADECLKA CNDIQEIEVF 250
TTRADTIYGV TYIAIAPEHP LVEHAIKQVN QEDLKTIKAI LNTTPRERTL 300
EKKGAFLGIY AIHPLTKQKI PIWVANFALA NYGSGALMGV PACDERDFEF 350
ANLYHIPIKV ITQSPQNLPH TKEETLKNSG EWSDLPSSVA REKIIAYFEK 400
ENLGKRVINY RLQDWGVSRQ RYWGAPIPMI HCKNCGIVPE TQLPVTLPED 450
IVIDGEGNPL EKHASWKFTQ CPKCHKDALR ETDTMDTFIQ SSWYFLRYTT 500
PKNQRENQAF DKNYLKYFMP VDTYIGGIEH AILHLLYARF FTKALRDLGY 550
IDLDEPFKQL ITQGMVLKDG VKMSKSKGNV VSPKEILKKY GADAARLFIL 600
FAAPPAKELE WNDSALEGAH RFIKRLYDKA NAINPTTYKP EFKEANLNEA 650
EKLARKKVYE ALKKSHEIFN NPESTYAFNT LIASCMEALN ALNTQNNERI 700
LCEGYFVLLQ VLEPMIPHTA WELSERLFKR ANFKPITIDE SALIEDSMTL 750
ALTINGKRRA ELKVHINASK EEILALAKKE LEKYLENASV KKEIYVPNKL 800
VNFVIA 806
Length:806
Mass (Da):93,375
Last modified:July 25, 2006 - v1
Checksum:iDA69A1CB76384ED2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99136.1.
RefSeqiYP_664135.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAJ99136; CAJ99136; Hac_0293.
GeneIDi4177613.
KEGGihac:Hac_0293.
PATRICi20584521. VBIHelAci71660_0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99136.1 .
RefSeqi YP_664135.1. NC_008229.1.

3D structure databases

ProteinModelPortali Q17YZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382638.Hac_0293.

Proteomic databases

PRIDEi Q17YZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ99136 ; CAJ99136 ; Hac_0293 .
GeneIDi 4177613.
KEGGi hac:Hac_0293.
PATRICi 20584521. VBIHelAci71660_0287.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HACI382638:GJAU-277-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheeba.

Entry informationi

Entry nameiSYL_HELAH
AccessioniPrimary (citable) accession number: Q17YZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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