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Q17YZ0

- SYL_HELAH

UniProt

Q17YZ0 - SYL_HELAH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei575 – 5751ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHACI382638:GJAU-277-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Hac_0293
    OrganismiHelicobacter acinonychis (strain Sheeba)
    Taxonomic identifieri382638 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000775: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Leucine--tRNA ligasePRO_0000334762Add
    BLAST

    Proteomic databases

    PRIDEiQ17YZ0.

    Interactioni

    Protein-protein interaction databases

    STRINGi382638.Hac_0293.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17YZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 4811"HIGH" regionAdd
    BLAST
    Motifi572 – 5765"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17YZ0-1 [UniParc]FASTAAdd to Basket

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    MDFVSIEKKW QEFWHQNESF EPKDDFNLPK KYILSMLPYP SGEIHMGHVR    50
    NYTIGDALVR YYRLHHYNVL HPMGFDSFGM PAENAAIKHG IHPKTWTYEN 100
    IENMQKEFEA LGFSFSKNRE FATSDPNYTE FEQQFFIDLW EKGLIYRKKA 150
    MLNWCPNDKT VLANEQVIEG RCWRCDTEVV QKELYQYYLK ITNYAEELLK 200
    DLETLKNHWP SQVLLMQKNW IGKSSGLQFR FKIADECLKA CNDIQEIEVF 250
    TTRADTIYGV TYIAIAPEHP LVEHAIKQVN QEDLKTIKAI LNTTPRERTL 300
    EKKGAFLGIY AIHPLTKQKI PIWVANFALA NYGSGALMGV PACDERDFEF 350
    ANLYHIPIKV ITQSPQNLPH TKEETLKNSG EWSDLPSSVA REKIIAYFEK 400
    ENLGKRVINY RLQDWGVSRQ RYWGAPIPMI HCKNCGIVPE TQLPVTLPED 450
    IVIDGEGNPL EKHASWKFTQ CPKCHKDALR ETDTMDTFIQ SSWYFLRYTT 500
    PKNQRENQAF DKNYLKYFMP VDTYIGGIEH AILHLLYARF FTKALRDLGY 550
    IDLDEPFKQL ITQGMVLKDG VKMSKSKGNV VSPKEILKKY GADAARLFIL 600
    FAAPPAKELE WNDSALEGAH RFIKRLYDKA NAINPTTYKP EFKEANLNEA 650
    EKLARKKVYE ALKKSHEIFN NPESTYAFNT LIASCMEALN ALNTQNNERI 700
    LCEGYFVLLQ VLEPMIPHTA WELSERLFKR ANFKPITIDE SALIEDSMTL 750
    ALTINGKRRA ELKVHINASK EEILALAKKE LEKYLENASV KKEIYVPNKL 800
    VNFVIA 806
    Length:806
    Mass (Da):93,375
    Last modified:July 25, 2006 - v1
    Checksum:iDA69A1CB76384ED2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAJ99136.1.
    RefSeqiYP_664135.1. NC_008229.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ99136; CAJ99136; Hac_0293.
    GeneIDi4177613.
    KEGGihac:Hac_0293.
    PATRICi20584521. VBIHelAci71660_0287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAJ99136.1 .
    RefSeqi YP_664135.1. NC_008229.1.

    3D structure databases

    ProteinModelPortali Q17YZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382638.Hac_0293.

    Proteomic databases

    PRIDEi Q17YZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ99136 ; CAJ99136 ; Hac_0293 .
    GeneIDi 4177613.
    KEGGi hac:Hac_0293.
    PATRICi 20584521. VBIHelAci71660_0287.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HACI382638:GJAU-277-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
      Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
      PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sheeba.

    Entry informationi

    Entry nameiSYL_HELAH
    AccessioniPrimary (citable) accession number: Q17YZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3