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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHACI382638:GJAU-277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Hac_0293
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligasePRO_0000334762Add
BLAST

Proteomic databases

PRIDEiQ17YZ0.

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_0293.

Structurei

3D structure databases

ProteinModelPortaliQ17YZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 4811"HIGH" regionAdd
BLAST
Motifi572 – 5765"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17YZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVSIEKKW QEFWHQNESF EPKDDFNLPK KYILSMLPYP SGEIHMGHVR
60 70 80 90 100
NYTIGDALVR YYRLHHYNVL HPMGFDSFGM PAENAAIKHG IHPKTWTYEN
110 120 130 140 150
IENMQKEFEA LGFSFSKNRE FATSDPNYTE FEQQFFIDLW EKGLIYRKKA
160 170 180 190 200
MLNWCPNDKT VLANEQVIEG RCWRCDTEVV QKELYQYYLK ITNYAEELLK
210 220 230 240 250
DLETLKNHWP SQVLLMQKNW IGKSSGLQFR FKIADECLKA CNDIQEIEVF
260 270 280 290 300
TTRADTIYGV TYIAIAPEHP LVEHAIKQVN QEDLKTIKAI LNTTPRERTL
310 320 330 340 350
EKKGAFLGIY AIHPLTKQKI PIWVANFALA NYGSGALMGV PACDERDFEF
360 370 380 390 400
ANLYHIPIKV ITQSPQNLPH TKEETLKNSG EWSDLPSSVA REKIIAYFEK
410 420 430 440 450
ENLGKRVINY RLQDWGVSRQ RYWGAPIPMI HCKNCGIVPE TQLPVTLPED
460 470 480 490 500
IVIDGEGNPL EKHASWKFTQ CPKCHKDALR ETDTMDTFIQ SSWYFLRYTT
510 520 530 540 550
PKNQRENQAF DKNYLKYFMP VDTYIGGIEH AILHLLYARF FTKALRDLGY
560 570 580 590 600
IDLDEPFKQL ITQGMVLKDG VKMSKSKGNV VSPKEILKKY GADAARLFIL
610 620 630 640 650
FAAPPAKELE WNDSALEGAH RFIKRLYDKA NAINPTTYKP EFKEANLNEA
660 670 680 690 700
EKLARKKVYE ALKKSHEIFN NPESTYAFNT LIASCMEALN ALNTQNNERI
710 720 730 740 750
LCEGYFVLLQ VLEPMIPHTA WELSERLFKR ANFKPITIDE SALIEDSMTL
760 770 780 790 800
ALTINGKRRA ELKVHINASK EEILALAKKE LEKYLENASV KKEIYVPNKL

VNFVIA
Length:806
Mass (Da):93,375
Last modified:July 25, 2006 - v1
Checksum:iDA69A1CB76384ED2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA. Translation: CAJ99136.1.
RefSeqiWP_011577251.1. NC_008229.1.
YP_664135.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAJ99136; CAJ99136; Hac_0293.
KEGGihac:Hac_0293.
PATRICi20584521. VBIHelAci71660_0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA. Translation: CAJ99136.1.
RefSeqiWP_011577251.1. NC_008229.1.
YP_664135.1. NC_008229.1.

3D structure databases

ProteinModelPortaliQ17YZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi382638.Hac_0293.

Proteomic databases

PRIDEiQ17YZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ99136; CAJ99136; Hac_0293.
KEGGihac:Hac_0293.
PATRICi20584521. VBIHelAci71660_0287.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciHACI382638:GJAU-277-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheeba.

Entry informationi

Entry nameiSYL_HELAH
AccessioniPrimary (citable) accession number: Q17YZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: April 29, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.