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Q17YQ7

- METK_HELAH

UniProt

Q17YQ7 - METK_HELAH

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Protein
S-adenosylmethionine synthase
Gene
metK, Hac_0382
Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme By similarity.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Binds 2 divalent ions per subunit. Magnesium or cobalt By similarity.
Binds 1 potassium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Magnesium By similarity
Metal bindingi44 – 441Potassium By similarity
Metal bindingi264 – 2641Potassium By similarity
Metal bindingi272 – 2721Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi260 – 2678ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. methionine adenosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. S-adenosylmethionine biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Cobalt, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciHACI382638:GJAU-361-MONOMER.
UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthase (EC:2.5.1.6)
Short name:
AdoMet synthase
Alternative name(s):
MAT
Methionine adenosyltransferase
Gene namesi
Name:metK
Ordered Locus Names:Hac_0382
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385S-adenosylmethionine synthaseUniRule annotation
PRO_0000302922Add
BLAST

Proteomic databases

PRIDEiQ17YQ7.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi382638.Hac_0382.

Structurei

3D structure databases

ProteinModelPortaliQ17YQ7.
SMRiQ17YQ7. Positions 6-380.

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase family.

Phylogenomic databases

eggNOGiCOG0192.
HOGENOMiHOG000245710.
KOiK00789.
OMAiGYVNSEM.
OrthoDBiEOG68WR6M.

Family and domain databases

HAMAPiMF_00086. S_AdoMet_synth1.
InterProiIPR022631. ADOMET_SYNTHASE_CS.
IPR022630. S-AdoMet_synt_C.
IPR022629. S-AdoMet_synt_central.
IPR022628. S-AdoMet_synt_N.
IPR002133. S-AdoMet_synthetase.
IPR022636. S-AdoMet_synthetase_sfam.
[Graphical view]
PANTHERiPTHR11964. PTHR11964. 1 hit.
PfamiPF02773. S-AdoMet_synt_C. 1 hit.
PF02772. S-AdoMet_synt_M. 1 hit.
PF00438. S-AdoMet_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000497. MAT. 1 hit.
SUPFAMiSSF55973. SSF55973. 3 hits.
TIGRFAMsiTIGR01034. metK. 1 hit.
PROSITEiPS00376. ADOMET_SYNTHASE_1. 1 hit.
PS00377. ADOMET_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17YQ7-1 [UniParc]FASTAAdd to Basket

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MKDSFLFTSE SVTEGHPDKM ADQISDAVLD YIIERDKKAK VACETLVSNG    50
FCVITGELKT SIYAPMQEIA REVVKKIGYT DALYGFDYRS AAVLNGIGEQ 100
SPDINQGVDR EDGEIGAGDQ GLVFGYACKE TQMLMPLPIH LAHQLTFALA 150
QKRKDNTLPF LRPDGKSQVS VRYENNKPIS IDTIVISTQH SPEVSQKHLK 200
EAVIEEIVYK VLPKEYLHDN IKFFVNPTGK FVIGGPQGDA GLTGRKIIVD 250
TYGGSCPHGG GAFSGKDPSK VDRSAAYAAR YVAKNLVASG VCDRATVQLA 300
YAIGVVEPVS IYVNTHNTSK YSSAELEKCV KLVFKLTPKG IIESLDLLRP 350
IYSLTSSYGH FGRELEAFTW EKTNKAEEIK AFFKH 385
Length:385
Mass (Da):42,358
Last modified:July 25, 2006 - v1
Checksum:iFA68A27F9790647A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99219.1.
RefSeqiYP_664218.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAJ99219; CAJ99219; Hac_0382.
GeneIDi4176762.
KEGGihac:Hac_0382.
PATRICi20584697. VBIHelAci71660_0374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99219.1 .
RefSeqi YP_664218.1. NC_008229.1.

3D structure databases

ProteinModelPortali Q17YQ7.
SMRi Q17YQ7. Positions 6-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382638.Hac_0382.

Proteomic databases

PRIDEi Q17YQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ99219 ; CAJ99219 ; Hac_0382 .
GeneIDi 4176762.
KEGGi hac:Hac_0382.
PATRICi 20584697. VBIHelAci71660_0374.

Phylogenomic databases

eggNOGi COG0192.
HOGENOMi HOG000245710.
KOi K00789.
OMAi GYVNSEM.
OrthoDBi EOG68WR6M.

Enzyme and pathway databases

UniPathwayi UPA00315 ; UER00080 .
BioCyci HACI382638:GJAU-361-MONOMER.

Family and domain databases

HAMAPi MF_00086. S_AdoMet_synth1.
InterProi IPR022631. ADOMET_SYNTHASE_CS.
IPR022630. S-AdoMet_synt_C.
IPR022629. S-AdoMet_synt_central.
IPR022628. S-AdoMet_synt_N.
IPR002133. S-AdoMet_synthetase.
IPR022636. S-AdoMet_synthetase_sfam.
[Graphical view ]
PANTHERi PTHR11964. PTHR11964. 1 hit.
Pfami PF02773. S-AdoMet_synt_C. 1 hit.
PF02772. S-AdoMet_synt_M. 1 hit.
PF00438. S-AdoMet_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000497. MAT. 1 hit.
SUPFAMi SSF55973. SSF55973. 3 hits.
TIGRFAMsi TIGR01034. metK. 1 hit.
PROSITEi PS00376. ADOMET_SYNTHASE_1. 1 hit.
PS00377. ADOMET_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheeba.

Entry informationi

Entry nameiMETK_HELAH
AccessioniPrimary (citable) accession number: Q17YQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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