Q17YI6 (AROA_HELAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Hac_0459

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012442

Sequences

	Sequence		Length	Mass (Da)
	Q17YI6 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: F1FE141DCA80F47D	FASTA	429	47,518
	10 20 30 40 50 60 MIELDINASD KSLSHRAVIF SLLAKKPCFV RNFLMGGDCL SSLEIAQNLG ARVENIAKNS 70 80 90 100 110 120 FKITPPWALK EPRKILNCNN SGTSMRLYSG LLSAQKGLFV LSGDNSLNSR PMKRIIEPLK 130 140 150 160 170 180 AFGTKILGRE DNHFAPLVIL GSPLKACDYE SPIASAQVKS AFILSALQAQ GTSTYRESEL 190 200 210 220 230 240 SRNHTEIMLK SLGANIKDQD GVLKISPLEK PLEAFDFKIA NDPSSAFFFA LACAILPKSR 250 260 270 280 290 300 LLLKNVLLNP TRIEAFEVLK KMGTHIECVI KSKDLEIIGD IYIEHALLKA ITIDQNIASL 310 320 330 340 350 360 IDEIPALGIA MLFAKGKSVV KNAKDLRSKE SDRIKALISN LKALGIECEE FEDGFYIEGL 370 380 390 400 410 420 EDISQLKQRF SQIKPPIIKS FNDHRIAMSF AILTLMLPLE IDNLECANIS FPQFKRLLNL FKKGSLHGN

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheeba.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260522 Genomic DNA. Translation: CAJ99290.1.
RefSeq	YP_664289.1. NC_008229.1.
3D structure databases
ProteinModelPortal	Q17YI6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q17YI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4176932.
GenomeReviews	Gene locus Hac_0459 in contig AM260522_GR.
KEGG	hac:Hac_0459.
NMPDR	fig|382638.8.peg.448.
PATRIC	20584855. VBIHelAci71660_0449.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	LECANIS.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	HACI382638:HAC_0459-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_HELAH

Accession

Primary (citable) accession number: Q17YI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program