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Q17Y01 (TRMB_HELAH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase

EC=2.1.1.33
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trmB
Ordered Locus Names:Hac_0671
OrganismHelicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]
Taxonomic identifier382638 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP-Rule MF_01057

Catalytic activity

S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine46 in tRNA. HAMAP-Rule MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_01057

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398tRNA (guanine-N(7)-)-methyltransferase HAMAP-Rule MF_01057
PRO_0000288157

Sites

Binding site1241S-adenosyl-L-methionine By similarity
Binding site1491S-adenosyl-L-methionine By similarity
Binding site1761S-adenosyl-L-methionine By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17Y01 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: FDA930604915A833

FASTA39846,494
        10         20         30         40         50         60 
MPHFLAKLDC KPLEYPIISG DFCFHKEFSS LKHPTKSCVY ASFKDHIFLL QKIRRANDFL 

        70         80         90        100        110        120 
IKSEKATPLK REILKQALRI YAQSFEVILH NLQENSKHAS GKKALDLEDF EDFIKENQAP 

       130        140        150        160        170        180 
ILMEIGFGSG RHLMELAKNN PTKTCLGIEI YTPSIAQVLK QIELLDLKNL HVLQGDGRLV 

       190        200        210        220        230        240 
LESIPHHKCE KIFVHFPVPW NDKKHRRVLS ERFLDEALRV LEPNGFLELR TDDTLYFEDS 

       250        260        270        280        290        300 
LKLALKHFKS EIEIKKNAQI PVVSKYEARW NKLKKDIYDL RIYSLESNET PFNNHAFDFS 

       310        320        330        340        350        360 
FDTITLNQKS VGMILKTPKI IKEGYFVHVC NIYENKGDFL VELSMGDFDW PMRLFVLSVK 

       370        380        390 
NQVFYLNKSP LKTLNNHKAH LLLQNILKEF DEYNHCSE 

« Hide

References

[1]"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sheeba.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260522 Genomic DNA. Translation: CAJ99475.1.
RefSeqYP_664474.1. NC_008229.1.

3D structure databases

ProteinModelPortalQ17Y01.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382638.Hac_0671.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ99475; CAJ99475; Hac_0671.
GeneID4176664.
KEGGhac:Hac_0671.
PATRIC20585243. VBIHelAci71660_0637.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0220.
HOGENOMHOG000252163.
KOK03439.
OMASKYEARW.
OrthoDBEOG6K6VBC.
ProtClustDBPRK14121.

Enzyme and pathway databases

BioCycHACI382638:GJAU-628-MONOMER.
UniPathwayUPA00989.

Family and domain databases

HAMAPMF_01057. tRNA_methyltr_TrmB.
InterProIPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00091. TIGR00091. 1 hit.
PROSITEPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_HELAH
AccessionPrimary (citable) accession number: Q17Y01
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways