Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124S-adenosyl-L-methionineUniRule annotation1
Binding sitei149S-adenosyl-L-methionineUniRule annotation1
Binding sitei176S-adenosyl-L-methionineUniRule annotation1
Binding sitei232SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHACI382638:G1G1M-598-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Hac_0671
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000775 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881571 – 398tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST398

Proteomic databases

PRIDEiQ17Y01

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_0671

Structurei

3D structure databases

ProteinModelPortaliQ17Y01
SMRiQ17Y01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000252163
KOiK03439
OMAiFVHFPVP
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q17Y01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHFLAKLDC KPLEYPIISG DFCFHKEFSS LKHPTKSCVY ASFKDHIFLL
60 70 80 90 100
QKIRRANDFL IKSEKATPLK REILKQALRI YAQSFEVILH NLQENSKHAS
110 120 130 140 150
GKKALDLEDF EDFIKENQAP ILMEIGFGSG RHLMELAKNN PTKTCLGIEI
160 170 180 190 200
YTPSIAQVLK QIELLDLKNL HVLQGDGRLV LESIPHHKCE KIFVHFPVPW
210 220 230 240 250
NDKKHRRVLS ERFLDEALRV LEPNGFLELR TDDTLYFEDS LKLALKHFKS
260 270 280 290 300
EIEIKKNAQI PVVSKYEARW NKLKKDIYDL RIYSLESNET PFNNHAFDFS
310 320 330 340 350
FDTITLNQKS VGMILKTPKI IKEGYFVHVC NIYENKGDFL VELSMGDFDW
360 370 380 390
PMRLFVLSVK NQVFYLNKSP LKTLNNHKAH LLLQNILKEF DEYNHCSE
Length:398
Mass (Da):46,494
Last modified:July 25, 2006 - v1
Checksum:iFDA930604915A833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA Translation: CAJ99475.1
RefSeqiWP_011577588.1, NC_008229.1

Genome annotation databases

EnsemblBacteriaiCAJ99475; CAJ99475; Hac_0671
GeneIDi31758126
KEGGihac:Hac_0671

Similar proteinsi

Entry informationi

Entry nameiTRMB_HELAH
AccessioniPrimary (citable) accession number: Q17Y01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health