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Q17Y01

- TRMB_HELAH

UniProt

Q17Y01 - TRMB_HELAH

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Hac_0671
Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241S-adenosyl-L-methionine By similarity
Binding sitei149 – 1491S-adenosyl-L-methionine By similarity
Binding sitei176 – 1761S-adenosyl-L-methionine By similarity
Binding sitei232 – 2321Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHACI382638:GJAU-628-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Hac_0671
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000288157Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_0671.

Structurei

3D structure databases

ProteinModelPortaliQ17Y01.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000252163.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17Y01-1 [UniParc]FASTAAdd to Basket

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MPHFLAKLDC KPLEYPIISG DFCFHKEFSS LKHPTKSCVY ASFKDHIFLL    50
QKIRRANDFL IKSEKATPLK REILKQALRI YAQSFEVILH NLQENSKHAS 100
GKKALDLEDF EDFIKENQAP ILMEIGFGSG RHLMELAKNN PTKTCLGIEI 150
YTPSIAQVLK QIELLDLKNL HVLQGDGRLV LESIPHHKCE KIFVHFPVPW 200
NDKKHRRVLS ERFLDEALRV LEPNGFLELR TDDTLYFEDS LKLALKHFKS 250
EIEIKKNAQI PVVSKYEARW NKLKKDIYDL RIYSLESNET PFNNHAFDFS 300
FDTITLNQKS VGMILKTPKI IKEGYFVHVC NIYENKGDFL VELSMGDFDW 350
PMRLFVLSVK NQVFYLNKSP LKTLNNHKAH LLLQNILKEF DEYNHCSE 398
Length:398
Mass (Da):46,494
Last modified:July 25, 2006 - v1
Checksum:iFDA930604915A833
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99475.1.
RefSeqiYP_664474.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAJ99475; CAJ99475; Hac_0671.
GeneIDi4176664.
KEGGihac:Hac_0671.
PATRICi20585243. VBIHelAci71660_0637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99475.1 .
RefSeqi YP_664474.1. NC_008229.1.

3D structure databases

ProteinModelPortali Q17Y01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382638.Hac_0671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ99475 ; CAJ99475 ; Hac_0671 .
GeneIDi 4176664.
KEGGi hac:Hac_0671.
PATRICi 20585243. VBIHelAci71660_0637.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000252163.
KOi K03439.
OMAi SKYEARW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HACI382638:GJAU-628-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheeba.

Entry informationi

Entry nameiTRMB_HELAH
AccessioniPrimary (citable) accession number: Q17Y01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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