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Q17Y01

- TRMB_HELAH

UniProt

Q17Y01 - TRMB_HELAH

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
    Binding sitei149 – 1491S-adenosyl-L-methionineUniRule annotation
    Binding sitei176 – 1761S-adenosyl-L-methionineUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHACI382638:GJAU-628-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Hac_0671
    OrganismiHelicobacter acinonychis (strain Sheeba)
    Taxonomic identifieri382638 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000775: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398tRNA (guanine-N(7)-)-methyltransferasePRO_0000288157Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382638.Hac_0671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17Y01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000252163.
    KOiK03439.
    OMAiSKYEARW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17Y01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPHFLAKLDC KPLEYPIISG DFCFHKEFSS LKHPTKSCVY ASFKDHIFLL    50
    QKIRRANDFL IKSEKATPLK REILKQALRI YAQSFEVILH NLQENSKHAS 100
    GKKALDLEDF EDFIKENQAP ILMEIGFGSG RHLMELAKNN PTKTCLGIEI 150
    YTPSIAQVLK QIELLDLKNL HVLQGDGRLV LESIPHHKCE KIFVHFPVPW 200
    NDKKHRRVLS ERFLDEALRV LEPNGFLELR TDDTLYFEDS LKLALKHFKS 250
    EIEIKKNAQI PVVSKYEARW NKLKKDIYDL RIYSLESNET PFNNHAFDFS 300
    FDTITLNQKS VGMILKTPKI IKEGYFVHVC NIYENKGDFL VELSMGDFDW 350
    PMRLFVLSVK NQVFYLNKSP LKTLNNHKAH LLLQNILKEF DEYNHCSE 398
    Length:398
    Mass (Da):46,494
    Last modified:July 25, 2006 - v1
    Checksum:iFDA930604915A833
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAJ99475.1.
    RefSeqiYP_664474.1. NC_008229.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ99475; CAJ99475; Hac_0671.
    GeneIDi4176664.
    KEGGihac:Hac_0671.
    PATRICi20585243. VBIHelAci71660_0637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAJ99475.1 .
    RefSeqi YP_664474.1. NC_008229.1.

    3D structure databases

    ProteinModelPortali Q17Y01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382638.Hac_0671.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ99475 ; CAJ99475 ; Hac_0671 .
    GeneIDi 4176664.
    KEGGi hac:Hac_0671.
    PATRICi 20585243. VBIHelAci71660_0637.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000252163.
    KOi K03439.
    OMAi SKYEARW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci HACI382638:GJAU-628-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
      Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
      PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sheeba.

    Entry informationi

    Entry nameiTRMB_HELAH
    AccessioniPrimary (citable) accession number: Q17Y01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3