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Q17XZ1 (DDL_HELAH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Hac_0681
OrganismHelicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]
Taxonomic identifier382638 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341108

Regions

Domain135 – 335201ATP-grasp
Nucleotide binding164 – 21956ATP By similarity

Sites

Metal binding2911Magnesium or manganese 1 By similarity
Metal binding3031Magnesium or manganese 1 By similarity
Metal binding3031Magnesium or manganese 2 By similarity
Metal binding3051Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17XZ1 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 9ADFFD462F654DE8

FASTA35039,997
        10         20         30         40         50         60 
MVEFCVLFGG ASFEHEISIV SAIALKEVLK DQIKYFIFLD ENHHFYLIEA SNMHSKYFAQ 

        70         80         90        100        110        120 
IKEKKLPPLM LTHNGLLKNS FLGAKTIELP LMINLVHGGD GEDGKLASLL EFYRIAFIGS 

       130        140        150        160        170        180 
RVEASVLSYN KHLTKLYAKN LGVKTLDCIL LNEKNRANAL DLIKPSFNFP FIVKPNNAGS 

       190        200        210        220        230        240 
SLGVSVVKEE KELAYALDGA FEYSKEVLIE PFIQRVKEYN LAGCKIKEDF CFSYVEEPNK 

       250        260        270        280        290        300 
QEFLDFKQKY LDFSRTKAPK ANIPNALEEQ LRENFKKLYN DLFDGAIIRC DFFVIDNEVY 

       310        320        330        340        350 
LNEINPIPGS LANYLFDDFK TTLENLAQSL PKTPKIQVKN SYLLQIQKNK 

« Hide

References

[1]"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sheeba.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260522 Genomic DNA. Translation: CAJ99485.1.
RefSeqYP_664484.1. NC_008229.1.

3D structure databases

ProteinModelPortalQ17XZ1.
SMRQ17XZ1. Positions 2-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382638.Hac_0681.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ99485; CAJ99485; Hac_0681.
GeneID4177122.
KEGGhac:Hac_0681.
PATRIC20585269. VBIHelAci71660_0650.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000102494.
KOK01921.
OMAHNGLLKN.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycHACI382638:GJAU-639-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_HELAH
AccessionPrimary (citable) accession number: Q17XZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways