Q17XF1 (DAPB_HELAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Hac_0897

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008572

Sequences

	Sequence		Length	Mass (Da)
	Q17XF1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 0482D8B972AF3571	FASTA	254	27,778
	10 20 30 40 50 60 MKIGVYGASG RIGKLLLEEL KGGYKGLVLS SVFVRQKCEI DFSSFSHKPL VTNDLKAFVR 70 80 90 100 110 120 ACECVIDFSL PKGVDSLLDT LLECPKILVS GTTGLEEKTL EKMQNLALKT PLLHAHNMSI 130 140 150 160 170 180 GIAILNQLAF LASLKLKDAD IEIVETHHNL KKDAPSGTAL SLYQTCAKAR GYDEKNALTT 190 200 210 220 230 240 HREGLRSKES IGVAALRGGD VAGKHTIGFY LEGEYIELSH TATNRSIFAK GALEVALWLK 250 DKAAKKYEIN EIFD

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheeba.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260522 Genomic DNA. Translation: CAJ99675.1.
RefSeq	YP_664674.1. NC_008229.1.
3D structure databases
ProteinModelPortal	Q17XF1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q17XF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4176402.
GenomeReviews	Gene locus Hac_0897 in contig AM260522_GR.
KEGG	hac:Hac_0897.
NMPDR	fig|382638.8.peg.871.
PATRIC	20585651. VBIHelAci71660_0841.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	IEISHKS.
PhylomeDB	Q17XF1.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	HACI382638:HAC_0897-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_HELAH

Accession

Primary (citable) accession number: Q17XF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program