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Q17X92 (Q17X92_HELAH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL CAJ99734.1
Ordered Locus Names:Hac_0961
OrganismHelicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]
Taxonomic identifier382638 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q17X92 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 77C8A4B0F926269F

FASTA83193,423
        10         20         30         40         50         60 
MQDYLINETK NIVEVGIDCS IEESYLAYSM SVIIGRALPD ARDGLKPVHR RILYAMNELG 

        70         80         90        100        110        120 
LTSKVAYKKS ARIVGDVIGK YHPHGDNAVY DALVRMAQDF SMRLELVDGQ GNFGSIDGDN 

       130        140        150        160        170        180 
AAAMRYTEAR MTKASEEILR DIDKDTIDFV PNYDDTLKEP DILPSRLPNL LVNGANGIAV 

       190        200        210        220        230        240 
GMATSIPPHR IDEIIDALVH VLENPNAELN EVLEFIKGPD FPTGGIIYGK VGIIEAYKTG 

       250        260        270        280        290        300 
RGRVKVRAKV HVEKTKNKEV IVLDEMPFQT NKAKLVEQIS DLAREKQIEG ISEVRDESDR 

       310        320        330        340        350        360 
EGIRVVIELK RDAMSEIVLN HLYKLTAMET TFSIILLAIY NKEPKIFTLL ELLHLFLNHR 

       370        380        390        400        410        420 
KTIIIRRTIF ELEKAKARAH ILEGYLIALD NIDEIVQLIK TSESPEMAKN TLMERFTLSE 

       430        440        450        460        470        480 
IQSKAILEMR LQRLTGLERD KIKEEYQNLL ELIDELNGIL KSEDRLNEVV KTELLEVKEQ 

       490        500        510        520        530        540 
FSSPRRTEIQ ESYENIDIED LIANEPMVVS MSYKGYVKRV DLKAYERQNR GGKGKLSGST 

       550        560        570        580        590        600 
YEGDFIESFF VANTHDILLF ITNKGQLYHL KVYKIPEASR IAMGKAIVNL ISLAPDEKIM 

       610        620        630        640        650        660 
ATLSTKDFSD ERSLAFFTKN GVVKRTNLSE FGSNRSYSGI RAIVLDEYDE LVSAKIVDKN 

       670        680        690        700        710        720 
SKHLLIASHS GTFIKFPLED VREIGRSARG VRGIRLNEND FVIGAVVISD DHNKLLSVSE 

       730        740        750        760        770        780 
NGLGKQTLAE SYREQARGGK GVIGMKLNKK TGNLVGIISV DDENLDLMIL TASAKMIRVS 

       790        800        810        820        830 
IKDIRETGRN ASGVKLIDAA DKVVYVNSCP KEEEPENLET PSTQKPQNLF E

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References

[1]"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM260522 Genomic DNA. Translation: CAJ99734.1.
RefSeqYP_664733.1. NC_008229.1.

3D structure databases

ProteinModelPortalQ17X92.
SMRQ17X92. Positions 34-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ17X92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4177277.
GenomeReviewsGene locus Hac_0961 in contig AM260522_GR.
KEGGhac:Hac_0961.
NMPDRfig|382638.8.peg.935.
PATRIC20585771. VBIHelAci71660_0901.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHBG635183.
OMATSIPPHR.
PhylomeDBQ17X92.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ17X92_HELAH
AccessionPrimary (citable) accession number: Q17X92
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info