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Q17X86 (Q17X86_HELAH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315 EMBL CAJ99740.1
Ordered Locus Names:Hac_0968
OrganismHelicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]
Taxonomic identifier382638 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS001017

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS001017

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS001017

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS001017

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS001017

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
Q17X86 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 8541C13070292448

FASTA61667,798
        10         20         30         40         50         60 
MQNKTFDLNP NDIASLEAVC QTLRERILEV VSTNGGHLSS SLGAVELIVG MHALFDCQKN 

        70         80         90        100        110        120 
PFIFDTSHQA YAHKLLTGRF ESFSTLRQFK GLSGFTKPSE SAYDYFIAGH SSTSVSVGVG 

       130        140        150        160        170        180 
VAKAFRLKQE LGMPIALLGD GSISAGIFYE ALNELGDRKY PMIMILNDNE MSISTPIGAL 

       190        200        210        220        230        240 
SKALSQLMKG PFYQSFRSKV KKILNTLPES VNYLVSRFEE SFKLITPGVF FEELGINYIG 

       250        260        270        280        290        300 
PINGHDLSTI IETLKLAREL KEPVLIHAQT LKGKGYKIAE GRYEKWHGVG PFDLDTGMSK 

       310        320        330        340        350        360 
KTKSAILSPT EIYSNTLLEL AKKDDKIVGV TAAMPSGTGL DKLIDAYPLR FFDVAIAEQH 

       370        380        390        400        410        420 
ALTSSSAMAK EGFKPFVSIY STFLQRAYDS IVHDACISSL PIKLAIDRAG IVGEDGETHQ 

       430        440        450        460        470        480 
GLLDVSYLRS IPNMVIFAPR DNETLKNAVH FANEYDLSPC AFRYPRGSFV LKEGVFEPSG 

       490        500        510        520        530        540 
FVLGQSELLQ KEGEILLIGY GNGVGRAYLV QLALKEKNIE CALLDLRFLK PLDHNLSSIV 

       550        560        570        580        590        600 
APYKKLYVFS DNYKLGGVAS AILEFLSEQN ILKPVKSFEI VDEFVMHGNT ALVEKSLGLD 

       610 
TESLTDAILK DLGQEK

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References

[1]"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM260522 Genomic DNA. Translation: CAJ99740.1.
RefSeqYP_664739.1. NC_008229.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ17X86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4176388.
GenomeReviewsGene locus Hac_0968 in contig AM260522_GR.
KEGGhac:Hac_0968.
NMPDRfig|382638.8.peg.941.
PATRIC20585783. VBIHelAci71660_0907.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMATRSYTQY.
PhylomeDBQ17X86.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ17X86_HELAH
AccessionPrimary (citable) accession number: Q17X86
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info