Q17WZ1 (SYE1_HELAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate--tRNA ligase 1
EC=6.1.1.17

Alternative name(s):
Glutamyl-tRNA synthetase 1
Short name=GluRS 1

Gene names

Name:	gltX1
Ordered Locus Names:	Hac_1071

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP MF_00022_B
Catalytic activity	ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP MF_00022_B
Subunit structure	Monomer By similarity. HAMAP MF_00022_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00022_B.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Glutamate--tRNA ligase 1 HAMAP MF_00022_B		PRO_0000367680
Regions
	Motif	6 – 16	11	"HIGH" region HAMAP MF_00022_B
	Motif	232 – 236	5	"KMSKS" region HAMAP MF_00022_B
Sites
	Binding site	235	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17WZ1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: CCE83AF43A82F840	FASTA	439	51,278
	10 20 30 40 50 60 MLRFAPSPTG DMHIGNLRAA IFNYIVAKQQ HKPFLIRIED TDKERNIEGK DQEILEILKL 70 80 90 100 110 120 MGMNWDKLVY QSHNIDYHRE MAEKLLKENK AFYCYASVGF LEQEKEKAKN EKRPFRYLDE 130 140 150 160 170 180 WAALEKNQHN TPVVRLKAPN HAVSFNDAIK KEVKFEPYEL DSFVLLRKDK SPTYNFACAC 190 200 210 220 230 240 DDLLYEISLI IRGEDHVSNT PKQILIQQAL GSNNPIIYAH LPIILDEASG KKMSKRDEAS 250 260 270 280 290 300 SVKWLLNQGF LPVAIVNYLI TIGNKVPKEV FSLDEALEWF SLENLSNSPA HFNLKYLKHL 310 320 330 340 350 360 NHQHLKRLDD EKLLELSQIK DRNLLGLLRL FIEECDTLLE LKEKISLFLE PKDIVKTYEN 370 380 390 400 410 420 EDFKERCSIL FNALKSMDFQ AYKDFESFKK EAMRLSQLKG KDFFKPLRIL LIGDSHGVEL 430 PLIFPYIQSH YQEILRLKA

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheeba.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260522 Genomic DNA. Translation: CAJ99835.1.
RefSeq	YP_664834.1. NC_008229.1.
3D structure databases
ProteinModelPortal	Q17WZ1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q17WZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4177262.
GenomeReviews	Gene locus Hac_1071 in contig AM260522_GR.
KEGG	hac:Hac_1071.
NMPDR	fig|382638.8.peg.1040.
PATRIC	20585984. VBIHelAci71660_1006.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0008.
HOGENOM	HBG628189.
OMA	SVKWLLN.
ProtClustDB	PRK12410.
Enzyme and pathway databases
BioCyc	HACI382638:HAC_1071-MONOMER.
Family and domain databases
HAMAP	MF_00022_B. Glu_tRNA_synth_B. [Tree]
InterPro	IPR008925. aa-tRNA-synth_I_codon-bd. IPR020751. aa-tRNA-synth_I_codon-bd_sub2. IPR001412. aa-tRNA-synth_I_CS. IPR004527. Glu-tRNA-synth_Ib_bac/mito. IPR000924. Glu/Gln-tRNA-synth_Ib. IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:1.10.1160.10. Glu/Gln-tRNA-synth_Ic_a-bdl. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits. G3DSA:1.10.10.350. tRNA_synt_bd. 1 hit.
KO	K01885.
PANTHER	PTHR10119. Glu_tRNA-synt_1c. 1 hit. PTHR10119:SF1. PTHR10119:SF1. 1 hit.
Pfam	PF00749. tRNA-synt_1c. 1 hit. [Graphical view]
PRINTS	PR00987. TRNASYNTHGLU.
SUPFAM	SSF48163. tRNA-synt_bind. 1 hit.
TIGRFAMs	TIGR00464. GltX_bact. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYE1_HELAH

Accession

Primary (citable) accession number: Q17WZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program