Reviewed, UniProtKB/Swiss-Prot Q17WR1 (ACSA_HELAH)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase
    Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	Hac_1156

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 662	662	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000065292
Sites
	Active site	527	1	By similarity
Amino acid modifications
	Modified residue	623	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17WR1-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 84B19724456B64F0	FASTA	662	74,921
	10 20 30 40 50 60 MQLDDDLEFA KKIFNPNRAF AKQARIKNMC EYKDLVHEAN ENYENFWGEL AKQKLTWFKP 70 80 90 100 110 120 FDKVLNSDNA PFFKWFENGK INVSYNCIDR HLKDKKNKVA IIFEGEMGDY NAITYRKLHS 130 140 150 160 170 180 EVNKTANLLK NEFNIKKGDR VIIYMPMIAE SVYMMLACTR IGAIHSIVFA GFSPEALRDR 190 200 210 220 230 240 INDAQAKLVI TADGTFRKGK PYMLKPALDK ALANNTCPSV EKTLIVIRNA KEIDYVRGRD 250 260 270 280 290 300 FVYNEMVNYQ SDKCEPEMMD SEDPLFLLYT SGSTGKPKGV QHSSAGYLLW AQMTMEWVFD 310 320 330 340 350 360 IRDNDNFWCT ADIGWITGHT YVVYGPLACG ATTLILEGTM SYPDYGRWWR MIEEYRVDKF 370 380 390 400 410 420 YTSPTAIRML HAKGENEPSK YNLDSLKVLG TVGEPINPTA WKWFYEKIGN SQCSIVDTWW 430 440 450 460 470 480 QTETGGHIIS PLPGATPIRA SCATLPLPGI HAEVLNEDGS KTKPGEQGFL CITKPWPSMI 490 500 510 520 530 540 RNIWGDEKRY IDSYFSQIQL NGEYVYLSGD GAIVDENGYI TIIGRTDDIV NVSGHRIGTA 550 560 570 580 590 600 EVESAISKHE MVVECAVVGI PDTIKGEGLF AFVVLCDGAK CNLGESLELL KEMNHILAVE 610 620 630 640 650 660 IGKIAKLDNV MYVPGLPKTR SGKIMRRILK SIVKKEPITQ DLSTLEDVNV VKEIINIAQM EE

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260522 Genomic DNA. Translation: CAJ99915.1.
RefSeq	YP_664914.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q17WR1.
Genome annotation databases
GeneID	4177696.
GenomeReviews	Gene locus Hac_1156 in contig AM260522_GR.
KEGG	hac:Hac_1156.
NMPDR	fig|382638.8.peg.1123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q17WR1.
OMA	TGGYNLY.
Enzyme and pathway databases
BioCyc	HACI382638:HAC_1156-MON.
Family and domain databases
HAMAP	MF_01123. [Tree]
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_HELAH

Accession

Primary (citable) accession number: Q17WR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 25, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)