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Q17WJ2

- LPXB_HELAH

UniProt

Q17WJ2 - LPXB_HELAH

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Hac_1230
Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHACI382638:GJAU-1142-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Hac_1230
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049402Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_1230.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17WJ2-1 [UniParc]FASTAAdd to Basket

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MPTILVSALE TSSNVHLEEL RRNLPKDYRF IGVFEGSGAL YSPREFSVMG    50
FRDVIGRLGF LFKVYKEMIQ LAKQADMVLL MDSSSFNIPL AKKIKKQDSH 100
KKIMYYILPQ VWAWKKWRAK TLEKYCDFLG AILPFEVSYY QKKAQYVGHP 150
LLDEIKYYKK DIKGETLVFM PGSRKSEIAK IFPLFVEVAR ILEQNEGFKR 200
RVLVVPSFFK GLDLKALYGE GIEWFEISYD AHKSLFEAEF AFICSGTATL 250
EAALIGTPFV LAYRAKTMDF LIARMFVNLH YIGLANIFYN ALNDETPGLG 300
ESQLHPELIQ HFLSVESLIR AYKDMDRERY FKESLKLREY LMHGSARKIA 350
SEIAFLLNLT 360
Length:360
Mass (Da):41,656
Last modified:July 25, 2006 - v1
Checksum:i987155A926C94FEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99984.1.
RefSeqiWP_011578091.1. NC_008229.1.
YP_664983.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAJ99984; CAJ99984; Hac_1230.
GeneIDi4177621.
KEGGihac:Hac_1230.
PATRICi20586302. VBIHelAci71660_1162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260522 Genomic DNA. Translation: CAJ99984.1 .
RefSeqi WP_011578091.1. NC_008229.1.
YP_664983.1. NC_008229.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382638.Hac_1230.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ99984 ; CAJ99984 ; Hac_1230 .
GeneIDi 4177621.
KEGGi hac:Hac_1230.
PATRICi 20586302. VBIHelAci71660_1162.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HACI382638:GJAU-1142-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheeba.

Entry informationi

Entry nameiLPXB_HELAH
AccessioniPrimary (citable) accession number: Q17WJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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