UniProtKB - Q17W92 (G6PI_HELAH)
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Protein
Glucose-6-phosphate isomerase
Gene
pgi
Organism
Helicobacter acinonychis (strain Sheeba)
Status
Functioni
Catalytic activityi
D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
: glycolysis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Glucose-6-phosphate isomerase (pgi)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 351 | Proton donorUniRule annotation | 1 | |
Active sitei | 382 | UniRule annotation | 1 | |
Active sitei | 510 | UniRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphate isomerase activity Source: UniProtKB-EC
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniPathway
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Gluconeogenesis, Glycolysis |
Enzyme and pathway databases
BioCyci | HACI382638:G1G1M-1173-MONOMER. |
UniPathwayi | UPA00109; UER00181. UPA00138. |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation |
Gene namesi | Name:pgiUniRule annotation Ordered Locus Names:Hac_1346 |
Organismi | Helicobacter acinonychis (strain Sheeba) |
Taxonomic identifieri | 382638 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000013975 | 1 – 545 | Glucose-6-phosphate isomeraseAdd BLAST | 545 |
Structurei
3D structure databases
ProteinModelPortali | Q17W92. |
SMRi | Q17W92. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GPI family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4107QP8. Bacteria. COG0166. LUCA. |
HOGENOMi | HOG000261370. |
KOi | K01810. |
OMAi | TNSQHAF. |
OrthoDBi | POG091H04C3. |
Family and domain databases
CDDi | cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit. |
Gene3Di | 1.10.1390.10. 1 hit. |
HAMAPi | MF_00473. G6P_isomerase. 1 hit. |
InterProi | View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2. |
PANTHERi | PTHR11469. PTHR11469. 1 hit. |
Pfami | View protein in Pfam PF00342. PGI. 1 hit. |
PRINTSi | PR00662. G6PISOMERASE. |
PROSITEi | View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q17W92-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTQLKTYPK LLKHYEEIKE MHMRDWFSKD KERASRYFVQ FESLSLDYSK
60 70 80 90 100
NRLNDTTLKL LFELARDCSL KEKIEAMFKG EKINTTEKRA VLHTALRSLN
110 120 130 140 150
DTEILLDNME VLKSVRSVLK RMRAFSDSVR SGKRLGYTNQ VITDIVNIGI
160 170 180 190 200
GGSDLGALMV CTALKRYAHP RLKMHFVSNV DGTQILDVLE KLNPASTLFI
210 220 230 240 250
VASKTFSTQE TLTNALTARK WFVERSGDEK HIAKHFVAVS TNKEAVQQFG
260 270 280 290 300
IDEHNMFEFW DFVGGRYSLW SAIGLSIMIY LGKKNFNALL KGAYLMDEHF
310 320 330 340 350
KNAPFESNLP VLMGLIGVWY INFFKSKSHL IAPYDQYLRH FPKFIQQLDM
360 370 380 390 400
ESNGKRISKK GETIPYDTCP VVWGDMGINA QHAFFQLLHQ GTHLIPIDFI
410 420 430 440 450
ASLDKKPNAK GHHEILFSNV LAQAQAFMKG KSYEEAFGEL LSKGLEKDEA
460 470 480 490 500
KDLAHHRVFF GNRPSNILLL EKISPSNMGA LVALYEHKVF VQGVIWDINS
510 520 530 540
FDQWGVELGK ELAVPILQEL EGHKSNAFFD SSTKHLIELY KNYNQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM260522 Genomic DNA. Translation: CAK00084.1. |
RefSeqi | WP_011578174.1. NC_008229.1. |
Genome annotation databases
EnsemblBacteriai | CAK00084; CAK00084; Hac_1346. |
GeneIDi | 31758662. |
KEGGi | hac:Hac_1346. |
Similar proteinsi
Entry informationi
Entry namei | G6PI_HELAH | |
Accessioni | Q17W92Primary (citable) accession number: Q17W92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 25, 2006 | |
Last modified: | February 28, 2018 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |