Q17W92 (G6PI_HELAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Hac_1346

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter acinonychis

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-HAMAP glycolytic process Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 545	545	Glucose-6-phosphate isomerase HAMAP-Rule MF_00473		PRO_1000013975
Sites
	Active site	351	1	Proton donor By similarity
	Active site	382	1	By similarity
	Active site	510	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17W92 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 5F0F368AB8F795E8	FASTA	545	62,423
	10 20 30 40 50 60 MLTQLKTYPK LLKHYEEIKE MHMRDWFSKD KERASRYFVQ FESLSLDYSK NRLNDTTLKL 70 80 90 100 110 120 LFELARDCSL KEKIEAMFKG EKINTTEKRA VLHTALRSLN DTEILLDNME VLKSVRSVLK 130 140 150 160 170 180 RMRAFSDSVR SGKRLGYTNQ VITDIVNIGI GGSDLGALMV CTALKRYAHP RLKMHFVSNV 190 200 210 220 230 240 DGTQILDVLE KLNPASTLFI VASKTFSTQE TLTNALTARK WFVERSGDEK HIAKHFVAVS 250 260 270 280 290 300 TNKEAVQQFG IDEHNMFEFW DFVGGRYSLW SAIGLSIMIY LGKKNFNALL KGAYLMDEHF 310 320 330 340 350 360 KNAPFESNLP VLMGLIGVWY INFFKSKSHL IAPYDQYLRH FPKFIQQLDM ESNGKRISKK 370 380 390 400 410 420 GETIPYDTCP VVWGDMGINA QHAFFQLLHQ GTHLIPIDFI ASLDKKPNAK GHHEILFSNV 430 440 450 460 470 480 LAQAQAFMKG KSYEEAFGEL LSKGLEKDEA KDLAHHRVFF GNRPSNILLL EKISPSNMGA 490 500 510 520 530 540 LVALYEHKVF VQGVIWDINS FDQWGVELGK ELAVPILQEL EGHKSNAFFD SSTKHLIELY KNYNQ

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheeba.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260522 Genomic DNA. Translation: CAK00084.1.
RefSeq	YP_665083.1. NC_008229.1.
3D structure databases
ProteinModelPortal	Q17W92.
SMR	Q17W92. Positions 2-542.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	382638.Hac_1346.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK00084; CAK00084; Hac_1346.
GeneID	4176772.
KEGG	hac:Hac_1346.
PATRIC	20586534. VBIHelAci71660_1272.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000261370.
KO	K01810.
OMA	NCHFVAN.
OrthoDB	EOG64R61J.
Enzyme and pathway databases
BioCyc	HACI382638:GJAU-1248-MONOMER.
UniPathway	UPA00109; UER00181. UPA00138.
Family and domain databases
Gene3D	1.10.1390.10. 1 hit.
HAMAP	MF_00473. G6P_isomerase.
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_HELAH

Accession

Primary (citable) accession number: Q17W92

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program