pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	351	Proton donorUniRule annotation	1
Active siteⁱ	382	UniRule annotation	1
Active siteⁱ	510	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.

UniPathwayⁱ

UPA00109; UER00181.
UPA00138.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:Hac_1346
Organismⁱ	Helicobacter acinonychis (strain Sheeba)
Taxonomic identifierⁱ	382638 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter acinonychis
Proteomesⁱ	UP000000775 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000013975	1 – 545	Glucose-6-phosphate isomeraseAdd BLAST		545

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	382638.Hac_1346.

STRINGⁱ

382638.Hac_1346.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q17W92.
SMRⁱ	Q17W92.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107QP8. Bacteria. COG0166. LUCA.
HOGENOMⁱ	HOG000261370.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	TNSQHAF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04C3.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit.
Gene3Dⁱ	1.10.1390.10. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q17W92-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLTQLKTYPK LLKHYEEIKE MHMRDWFSKD KERASRYFVQ FESLSLDYSK 
        60         70         80         90        100
NRLNDTTLKL LFELARDCSL KEKIEAMFKG EKINTTEKRA VLHTALRSLN 
       110        120        130        140        150
DTEILLDNME VLKSVRSVLK RMRAFSDSVR SGKRLGYTNQ VITDIVNIGI 
       160        170        180        190        200
GGSDLGALMV CTALKRYAHP RLKMHFVSNV DGTQILDVLE KLNPASTLFI 
       210        220        230        240        250
VASKTFSTQE TLTNALTARK WFVERSGDEK HIAKHFVAVS TNKEAVQQFG 
       260        270        280        290        300
IDEHNMFEFW DFVGGRYSLW SAIGLSIMIY LGKKNFNALL KGAYLMDEHF 
       310        320        330        340        350
KNAPFESNLP VLMGLIGVWY INFFKSKSHL IAPYDQYLRH FPKFIQQLDM 
       360        370        380        390        400
ESNGKRISKK GETIPYDTCP VVWGDMGINA QHAFFQLLHQ GTHLIPIDFI 
       410        420        430        440        450
ASLDKKPNAK GHHEILFSNV LAQAQAFMKG KSYEEAFGEL LSKGLEKDEA 
       460        470        480        490        500
KDLAHHRVFF GNRPSNILLL EKISPSNMGA LVALYEHKVF VQGVIWDINS 
       510        520        530        540 
FDQWGVELGK ELAVPILQEL EGHKSNAFFD SSTKHLIELY KNYNQ

Length:545

Mass (Da):62,423

Last modified:July 25, 2006 - v1

Checksum:ⁱ5F0F368AB8F795E8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM260522 Genomic DNA. Translation: CAK00084.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011578174.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAK00084; CAK00084; Hac_1346.
GeneIDⁱ	31758662.
KEGGⁱ	hac:Hac_1346.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q17W92	I0EUQ9 I0EPJ0 D0K0N9 UPI0002FF71BC M3S6F8 UPI0003478C46 B6JN06 A0A0M8NL84 B5Z8G1 Q1CSA0 +430	Helicobacter acinonychis (strain Sheeba) Helicobacter cetorum (strain ATCC BAA-540 / MIT 99-5656) Helicobacter cetorum (strain ATCC BAA-429 / MIT 00-7128) Helicobacter pylori (strain 52) Helicobacter pylori (Campylobacter pylori) Helicobacter pylori GAM93Bi Helicobacter pylori (strain P12) Helicobacter pylori (strain G27) Helicobacter pylori (strain HPAG1) Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) And more	545	UniRef90_Q17W92	Cluster: Glucose-6-phosphate isomerase	441

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q17W92	B2UF65 D8NBU5 UPI00039DECC5 UPI0002F98020 S9S1C3 A0A124BTU8 UPI0005771D47 A0A0S4V3R2 R0CUR8 UPI00048B817F +1235	Ralstonia pickettii (strain 12J) Ralstonia solanacearum CMR15 Ralstonia solanacearum (Pseudomonas solanacearum) Ralstonia sp. AU12-08 Ralstonia sp. NT80 Ralstonia pickettii OR214 Ralstonia solanacearum (strain Po82) Ralstonia mannitolilytica Ralstonia syzygii R24 Ralstonia solanacearum FJAT-1458 And more	539	UniRef50_B2UF65	Cluster: Glucose-6-phosphate isomerase	1,246

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM260522 Genomic DNA. Translation: CAK00084.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011578174.1. NC_008229.1.

3D structure databases

ProteinModelPortalⁱ	Q17W92.
SMRⁱ	Q17W92.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	382638.Hac_1346.

STRINGⁱ

382638.Hac_1346.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAK00084; CAK00084; Hac_1346.
GeneIDⁱ	31758662.
KEGGⁱ	hac:Hac_1346.

Phylogenomic databases

eggNOGⁱ	ENOG4107QP8. Bacteria. COG0166. LUCA.
HOGENOMⁱ	HOG000261370.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	TNSQHAF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04C3.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.

UniPathwayⁱ

UPA00109; UER00181.
UPA00138.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit.
Gene3Dⁱ	1.10.1390.10. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_HELAH
Accessionⁱ	Q17W92Primary (citable) accession number: Q17W92
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	July 25, 2006
	Last modified:	August 30, 2017
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q17W92 (G6PI_HELAH)

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ