pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	351	Proton donorUniRule annotation	1
Active siteⁱ	382	UniRule annotation	1
Active siteⁱ	510	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCycⁱ	HACI382638:HAC_RS05780-MONOMER
UniPathwayⁱ	UPA00109; UER00181 UPA00138

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:Hac_1346
Organismⁱ	Helicobacter acinonychis (strain Sheeba)
Taxonomic identifierⁱ	382638 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter acinonychis
Proteomesⁱ	UP000000775 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000013975	1 – 545	Glucose-6-phosphate isomeraseAdd BLAST		545

Proteomic databases

PRIDEⁱ	Q17W92

PRIDEⁱ

Q17W92

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	382638.Hac_1346

STRINGⁱ

382638.Hac_1346

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q17W92
SMRⁱ	Q17W92
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107QP8 Bacteria COG0166 LUCA
HOGENOMⁱ	HOG000261370
KEGG Orthology (KO) More...KOⁱ	K01810
OMAⁱ	TNSQHAF
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04C3

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit
Gene3Dⁱ	1.10.1390.10, 1 hit
HAMAPⁱ	MF_00473 G6P_isomerase, 1 hit
InterProⁱ	View protein in InterPro IPR001672 G6P_Isomerase IPR023096 G6P_Isomerase_C IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2
PANTHERⁱ	PTHR11469 PTHR11469, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342 PGI, 1 hit
PRINTSⁱ	PR00662 G6PISOMERASE
PROSITEⁱ	View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q17W92-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLTQLKTYPK LLKHYEEIKE MHMRDWFSKD KERASRYFVQ FESLSLDYSK 
        60         70         80         90        100
NRLNDTTLKL LFELARDCSL KEKIEAMFKG EKINTTEKRA VLHTALRSLN 
       110        120        130        140        150
DTEILLDNME VLKSVRSVLK RMRAFSDSVR SGKRLGYTNQ VITDIVNIGI 
       160        170        180        190        200
GGSDLGALMV CTALKRYAHP RLKMHFVSNV DGTQILDVLE KLNPASTLFI 
       210        220        230        240        250
VASKTFSTQE TLTNALTARK WFVERSGDEK HIAKHFVAVS TNKEAVQQFG 
       260        270        280        290        300
IDEHNMFEFW DFVGGRYSLW SAIGLSIMIY LGKKNFNALL KGAYLMDEHF 
       310        320        330        340        350
KNAPFESNLP VLMGLIGVWY INFFKSKSHL IAPYDQYLRH FPKFIQQLDM 
       360        370        380        390        400
ESNGKRISKK GETIPYDTCP VVWGDMGINA QHAFFQLLHQ GTHLIPIDFI 
       410        420        430        440        450
ASLDKKPNAK GHHEILFSNV LAQAQAFMKG KSYEEAFGEL LSKGLEKDEA 
       460        470        480        490        500
KDLAHHRVFF GNRPSNILLL EKISPSNMGA LVALYEHKVF VQGVIWDINS 
       510        520        530        540 
FDQWGVELGK ELAVPILQEL EGHKSNAFFD SSTKHLIELY KNYNQ

Length:545

Mass (Da):62,423

Last modified:July 25, 2006 - v1

Checksum:ⁱ5F0F368AB8F795E8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM260522 Genomic DNA Translation: CAK00084.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011578174.1, NC_008229.1

Genome annotation databases

EnsemblBacteriaⁱ	CAK00084; CAK00084; Hac_1346
GeneIDⁱ	31758662
KEGGⁱ	hac:Hac_1346

Protein	Similar proteins		Species	Score	Length
Q17W92	Glucose-6-phosphate isomerase		HELC0		548
Glucose-6-phosphate isomerase		HELCM		548
UPI000CF18DA2		Helicobacter cetorum		548
Glucose-6-phosphate isomerase		HELP5		546
UPI0002FF71BC		HELPX		545
+570

Protein	Similar proteins		Species	Score	Length
Q17W92	Glucose-6-phosphate isomerase	)	MOUSE		558
Glucose-6-phosphate isomerase		RAT		558
UPI0004ED5B4E		NANGA		558
UPI000A3192F0		MUSCR		558
UPI00042AA2CA		PERMB		558
+1506

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM260522 Genomic DNA Translation: CAK00084.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011578174.1, NC_008229.1

3D structure databases

ProteinModelPortalⁱ	Q17W92
SMRⁱ	Q17W92
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	382638.Hac_1346

STRINGⁱ

382638.Hac_1346

Proteomic databases

PRIDEⁱ	Q17W92

PRIDEⁱ

Q17W92

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAK00084; CAK00084; Hac_1346
GeneIDⁱ	31758662
KEGGⁱ	hac:Hac_1346

Phylogenomic databases

eggNOGⁱ	ENOG4107QP8 Bacteria COG0166 LUCA
HOGENOMⁱ	HOG000261370
KEGG Orthology (KO) More...KOⁱ	K01810
OMAⁱ	TNSQHAF
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04C3

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181 UPA00138
BioCycⁱ	HACI382638:HAC_RS05780-MONOMER

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit
Gene3Dⁱ	1.10.1390.10, 1 hit
HAMAPⁱ	MF_00473 G6P_isomerase, 1 hit
InterProⁱ	View protein in InterPro IPR001672 G6P_Isomerase IPR023096 G6P_Isomerase_C IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2
PANTHERⁱ	PTHR11469 PTHR11469, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342 PGI, 1 hit
PRINTSⁱ	PR00662 G6PISOMERASE
PROSITEⁱ	View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_HELAH
Accessionⁱ	Q17W92Primary (citable) accession number: Q17W92
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	July 25, 2006
	Last modified:	June 20, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q17W92 (G6PI_HELAH)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ