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Q17W06

- AMPA_HELAH

UniProt

Q17W06 - AMPA_HELAH

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi258 – 2581Manganese 2UniRule annotation
    Metal bindingi263 – 2631Manganese 1UniRule annotation
    Metal bindingi263 – 2631Manganese 2UniRule annotation
    Active sitei270 – 2701UniRule annotation
    Metal bindingi281 – 2811Manganese 2UniRule annotation
    Metal bindingi340 – 3401Manganese 1UniRule annotation
    Metal bindingi342 – 3421Manganese 1UniRule annotation
    Metal bindingi342 – 3421Manganese 2UniRule annotation
    Active sitei344 – 3441UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciHACI382638:GJAU-1335-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
    Short name:
    LAPUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:Hac_1442
    OrganismiHelicobacter acinonychis (strain Sheeba)
    Taxonomic identifieri382638 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000775: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Probable cytosol aminopeptidasePRO_1000019926Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382638.Hac_1442.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17W06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243129.
    KOiK01255.
    OMAiGMENMTS.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17W06-1 [UniParc]FASTAAdd to Basket

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    MLKIKLEKSA FENAKAECSL VFIVNKDFNH AWVKNKKLLE TFRYEGEDSF    50
    LDQENKILYV GVKEDNVHLL RESACSAIRT LKKLAFKSVK VGVYTCHTHS 100
    KDNALLENLK ALFLGLKLGM YEYDTFKSNK KESVLKEAII ALELHKPCEE 150
    TCANSLEKSA KEALKYADVM TESLNITKNL VNTPPMIGTP IYMAEVAQKV 200
    AKEGNLEIHV YDEKFLEEKK MNAFLAVNKA SLGVNPPRLI HLIYKPKKAK 250
    KKIALVGKGL TYDCGGLSLK PADYMVTMKA DKGGGSAVIG LLNALSNLGV 300
    EAEVHGIIGA TENMIGPAAY KPDDILISKE GKSIEVRNTD AEGRLVLADC 350
    LSYAQDLNPD VIVDFATLTG ACVVGLGEFT SAIMGHNEEL KNLFETSGLE 400
    SGELLAKLPF NRHLKKLIES KIADVCNVSA SRYGGAITAG LFLNEFIRDE 450
    FKDKWLHIDI AGPAYVEKEW DVNSFGASGA GVRACTAFVE ELLKKA 496
    Length:496
    Mass (Da):54,522
    Last modified:July 25, 2006 - v1
    Checksum:iCDCC18C244A6B076
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAK00170.1.
    RefSeqiWP_011578260.1. NC_008229.1.
    YP_665169.1. NC_008229.1.

    Genome annotation databases

    EnsemblBacteriaiCAK00170; CAK00170; Hac_1442.
    GeneIDi4176744.
    KEGGihac:Hac_1442.
    PATRICi20586722. VBIHelAci71660_1365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260522 Genomic DNA. Translation: CAK00170.1 .
    RefSeqi WP_011578260.1. NC_008229.1.
    YP_665169.1. NC_008229.1.

    3D structure databases

    ProteinModelPortali Q17W06.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382638.Hac_1442.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK00170 ; CAK00170 ; Hac_1442 .
    GeneIDi 4176744.
    KEGGi hac:Hac_1442.
    PATRICi 20586722. VBIHelAci71660_1365.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243129.
    KOi K01255.
    OMAi GMENMTS.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci HACI382638:GJAU-1335-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
      Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
      PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sheeba.

    Entry informationi

    Entry nameiAMPA_HELAH
    AccessioniPrimary (citable) accession number: Q17W06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3