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Q17W06

- AMPA_HELAH

UniProt

Q17W06 - AMPA_HELAH

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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Manganese 2UniRule annotation
Metal bindingi263 – 2631Manganese 1UniRule annotation
Metal bindingi263 – 2631Manganese 2UniRule annotation
Active sitei270 – 2701UniRule annotation
Metal bindingi281 – 2811Manganese 2UniRule annotation
Metal bindingi340 – 3401Manganese 1UniRule annotation
Metal bindingi342 – 3421Manganese 1UniRule annotation
Metal bindingi342 – 3421Manganese 2UniRule annotation
Active sitei344 – 3441UniRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHACI382638:GJAU-1335-MONOMER.

Protein family/group databases

MEROPSiM17.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:Hac_1442
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000775: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable cytosol aminopeptidasePRO_1000019926Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_1442.

Structurei

3D structure databases

ProteinModelPortaliQ17W06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiGMENMTS.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17W06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKIKLEKSA FENAKAECSL VFIVNKDFNH AWVKNKKLLE TFRYEGEDSF
60 70 80 90 100
LDQENKILYV GVKEDNVHLL RESACSAIRT LKKLAFKSVK VGVYTCHTHS
110 120 130 140 150
KDNALLENLK ALFLGLKLGM YEYDTFKSNK KESVLKEAII ALELHKPCEE
160 170 180 190 200
TCANSLEKSA KEALKYADVM TESLNITKNL VNTPPMIGTP IYMAEVAQKV
210 220 230 240 250
AKEGNLEIHV YDEKFLEEKK MNAFLAVNKA SLGVNPPRLI HLIYKPKKAK
260 270 280 290 300
KKIALVGKGL TYDCGGLSLK PADYMVTMKA DKGGGSAVIG LLNALSNLGV
310 320 330 340 350
EAEVHGIIGA TENMIGPAAY KPDDILISKE GKSIEVRNTD AEGRLVLADC
360 370 380 390 400
LSYAQDLNPD VIVDFATLTG ACVVGLGEFT SAIMGHNEEL KNLFETSGLE
410 420 430 440 450
SGELLAKLPF NRHLKKLIES KIADVCNVSA SRYGGAITAG LFLNEFIRDE
460 470 480 490
FKDKWLHIDI AGPAYVEKEW DVNSFGASGA GVRACTAFVE ELLKKA
Length:496
Mass (Da):54,522
Last modified:July 25, 2006 - v1
Checksum:iCDCC18C244A6B076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA. Translation: CAK00170.1.
RefSeqiWP_011578260.1. NC_008229.1.
YP_665169.1. NC_008229.1.

Genome annotation databases

EnsemblBacteriaiCAK00170; CAK00170; Hac_1442.
GeneIDi4176744.
KEGGihac:Hac_1442.
PATRICi20586722. VBIHelAci71660_1365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA. Translation: CAK00170.1 .
RefSeqi WP_011578260.1. NC_008229.1.
YP_665169.1. NC_008229.1.

3D structure databases

ProteinModelPortali Q17W06.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382638.Hac_1442.

Protein family/group databases

MEROPSi M17.010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK00170 ; CAK00170 ; Hac_1442 .
GeneIDi 4176744.
KEGGi hac:Hac_1442.
PATRICi 20586722. VBIHelAci71660_1365.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi GMENMTS.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci HACI382638:GJAU-1335-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."
    Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C.
    PLoS Genet. 2:1097-1110(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheeba.

Entry informationi

Entry nameiAMPA_HELAH
AccessioniPrimary (citable) accession number: Q17W06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3