Reviewed, UniProtKB/Swiss-Prot Q17VY9 (LUXS_HELAH)

Names and origin

Protein names

Recommended name:
    S-ribosylhomocysteine lyase
    EC=4.4.1.21
Alternative name(s):
    Autoinducer-2 production protein luxS
    AI-2 synthesis protein

Gene names

Name:	luxS
Ordered Locus Names:	Hac_1463

Organism

Helicobacter acinonychis (strain Sheeba) [Complete proteome] [HAMAP]

Taxonomic identifier

382638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091
Cofactor	Binds 1 iron ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the luxS family.

Ontologies

Keywords
Biological process	Autoinducer synthesis Quorum sensing
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: HAMAP
Molecular function	S-ribosylhomocysteine lyase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	S-ribosylhomocysteine lyase HAMAP MF_00091		PRO_0000298001
Sites
	Metal binding	60	1	Iron By similarity
	Metal binding	64	1	Iron By similarity
	Metal binding	127	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17VY9-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 3827ED808FAEB261	FASTA	157	17,963
	10 20 30 40 50 60 MKTPNTKMNV ESFNLDHTKV KAPYVRIADR KKGINGDLIV KYDVRFKQPN QEHMDMPSLH 70 80 90 100 110 120 SLEHLVAEII RNHANYVVDW SPMGCQTGFY LTVLNHDNYT EILEVLEKTM QDVLKATEVP 130 140 150 ASNEKQCGWA ANHTLEGAKN LAHAFLSKRD EWSEIGI

References

[1]

"Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines." Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. PLoS Genet. 2:1097-1110(2006) [PubMed: 16789826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260522 Genomic DNA. Translation: CAK00187.1.
RefSeq	YP_665186.1.
3D structure databases
SMR	Q17VY9. Positions 7-157.
ModBase	Search...
Protein-protein interaction databases
STRING	Q17VY9.
Genome annotation databases
GeneID	4177626.
GenomeReviews	Gene locus Hac_1463 in contig AM260522_GR.
KEGG	hac:Hac_1463.
NMPDR	fig|382638.8.peg.1417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q17VY9.
OMA	VRIAKTM.
Enzyme and pathway databases
BioCyc	HACI382638:HAC_1463-MON.
Family and domain databases
HAMAP	MF_00091. [Tree]
InterPro	IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. LuxS. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

LUXS_HELAH

Accession

Primary (citable) accession number: Q17VY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	July 25, 2006
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)