Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Helicobacter acinonychis (strain Sheeba)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi484MagnesiumUniRule annotation1
Metal bindingi490MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciHACI382638:G1G1M-1371-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Hac_1591
OrganismiHelicobacter acinonychis (strain Sheeba)
Taxonomic identifieri382638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000775 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296761 – 688Polyribonucleotide nucleotidyltransferaseAdd BLAST688

Proteomic databases

PRIDEiQ17VM4

Interactioni

Protein-protein interaction databases

STRINGi382638.Hac_1591

Structurei

3D structure databases

ProteinModelPortaliQ17VM4
SMRiQ17VM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini550 – 609KHUniRule annotationAdd BLAST60
Domaini626 – 688S1 motifUniRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q17VM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFITINSIN KTEEFALKQV AKQATSSLLY RLGKTIILAS VCVERELVSE
60 70 80 90 100
DFLPLVVQFL EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTLRPLFP
110 120 130 140 150
KDYRYPTQIT LMVLSHDIEN DLQVSALNAA SAALFLAHAA PFKSVSACRI
160 170 180 190 200
ARIDNEFIIN PSTSLLNQSS LDLFVSGTKE SLNMIEMRSL GQKLNALEEP
210 220 230 240 250
LMLEALELAQ KSLKETCTLY EETFTPHQNA LLFKESQGIV FNERLLDLLK
260 270 280 290 300
NQYFNEIIKG IESSALSERE NVFNEIARKI SEAHSEFNLE EIELSLEKVK
310 320 330 340 350
KTEIRRMIIR DKIRPDKRAL EEVRPISIES NLLPMAHSSI LFTRGQTQSL
360 370 380 390 400
VVGVLGTDND AQTHESLEHK APIKERFMFH YNFPPFCVGE ASSIGATSRR
410 420 430 440 450
ELGHGNLAKR ALETSIKNKD QVIRLVSEIL ESNGSSSMAS VCAGSLALYA
460 470 480 490 500
SGVEIHDLVA GVAMGMVSEG QDYAILSDIS GLEDAEGDMD FKIAGNLEGI
510 520 530 540 550
TAMQMDTKMS GIQLEILYQT LLQAKRVREH ILKIMHEAKE KIVINFSHLP
560 570 580 590 600
TTEIFNVAPD KIIEIIGQGG RVIREIVEKF EVKIDLNKPS GEVKIMGNKE
610 620 630 640 650
RVLKTKEFIL NYLHSLDQEL EQYAIDEVLE AQVKRIVDFG AFLSLPKGGE
660 670 680
GLLRKQHMER CQVALKEGDS IRCRVISFNK GKIALDLA
Length:688
Mass (Da):77,044
Last modified:July 25, 2006 - v1
Checksum:i837788E61EE63F4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260522 Genomic DNA Translation: CAK00302.1
RefSeqiWP_011578385.1, NC_008229.1

Genome annotation databases

EnsemblBacteriaiCAK00302; CAK00302; Hac_1591
GeneIDi31758849
KEGGihac:Hac_1591

Similar proteinsi

Entry informationi

Entry nameiPNP_HELAH
AccessioniPrimary (citable) accession number: Q17VM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health