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Protein

Protein BREVIS RADIX

Gene

BRX

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of cell proliferation and elongation in the root and shoot. Probable transcription regulator. Regulated by the auxin response factor ARF5. Polarly localized in vascular cells and subject to endocytic recycling. Required for CPD expression and for correct nuclear auxin response. Mediates cross-talk between the auxin and brassinosteroid pathways. BRX is a target for auxin-induced, proteasome-mediated degradation.5 Publications

Miscellaneous

The truncated variant in cv. Uk-1 results in short root phenotype.

GO - Biological processi

  • auxin-activated signaling pathway Source: TAIR
  • cytokinin-activated signaling pathway Source: TAIR
  • lateral root development Source: TAIR
  • response to abscisic acid Source: TAIR
  • root development Source: TAIR

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BREVIS RADIX
Short name:
AtBRX
Gene namesi
Name:BRX
Ordered Locus Names:At1g31880
ORF Names:F5M6.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G31880.
TAIRilocus:2034486. AT1G31880.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Short primary root and increased number of lateral roots. Reduced cotyledon and leaf size. Enhanced response to abscisic acid-mediated inhibition of root growth and insensitivity to cytokinin induced inhibition of lateral root initiation.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003738211 – 344Protein BREVIS RADIXAdd BLAST344

Proteomic databases

PaxDbiQ17TI5.

Expressioni

Tissue specificityi

Expressed in the developing protophloem up to the elongation zone in root meristem of young seedlings, in the columella and the phloem vasculature throughout the root and in the phloem vasculature in the shoot. Detected in the shoot meristem and in primordia. Low expression in stomata.4 Publications

Developmental stagei

Ubiquitously expressed in early embryos and becomes restricted to the vasculature in the mature embryo and at later stages of development.1 Publication

Inductioni

Up-regulated by auxin and down-regulated by brassinolide.1 Publication

Gene expression databases

ExpressionAtlasiQ17TI5. baseline and differential.
GenevisibleiQ17TI5. AT.

Interactioni

Subunit structurei

Homodimer and heterodimer with BRXL1. Interacts with NGA1 and ARF5.3 Publications

Protein-protein interaction databases

BioGridi25312. 28 interactors.
IntActiQ17TI5. 26 interactors.
STRINGi3702.AT1G31880.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 194BRX 1PROSITE-ProRule annotationAdd BLAST56
Domaini289 – 344BRX 2PROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 62Poly-Ser4

Domaini

The DZC domain is necessary and sufficient for dimerization. A C-terminal fragment containing both DZC domains is able to rescue the short root phenotype. The N-terminal part (1-57) promotes BRX membrane association and is required for efficient degradation in the nucleus.1 Publication

Sequence similaritiesi

Belongs to the BRX family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEZR. Eukaryota.
ENOG410YFJP. LUCA.
HOGENOMiHOG000240563.
InParanoidiQ17TI5.
OMAiGESEWIA.
OrthoDBiEOG09360EZZ.
PhylomeDBiQ17TI5.

Family and domain databases

InterProiView protein in InterPro
IPR013591. Brevis_radix_dom.
IPR027988. BRX_N.
PfamiView protein in Pfam
PF08381. BRX. 2 hits.
PF13713. BRX_N. 1 hit.
PROSITEiView protein in PROSITE
PS51514. BRX. 2 hits.

Sequencei

Sequence statusi: Complete.

Q17TI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSCIACTKA DGGEEVEHGA RGGTTPNTKE AVKSLTIQIK DMALKFSGAY
60 70 80 90 100
KQCKPCTGSS SSPLKKGHRS FPDYDNASEG VPYPFMGGSA GSTPAWDFTN
110 120 130 140 150
SSHHPAGRLE SKFTSIYGND RESISAQSCD VVLDDDGPKE WMAQVEPGVH
160 170 180 190 200
ITFASLPTGG NDLKRIRFSR EMFDKWQAQR WWGENYDKIV ELYNVQRFNR
210 220 230 240 250
QALQTPARSD DQSQRDSTYS KMDSARESKD WTPRHNFRPP GSVPHHFYGG
260 270 280 290 300
SSNYGPGSYH GGPPMDAART TTSSRDDPPS MSNASEMQAE WIEEDEPGVY
310 320 330 340
ITIRQLSDGT RELRRVRFSR ERFGEVHAKT WWEQNRERIQ TQYL
Length:344
Mass (Da):38,761
Last modified:May 5, 2009 - v2
Checksum:iD36075D26158FFD7
GO

Sequence cautioni

The sequence AAG50720 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti141 – 344Missing in strain: cv. Uk-1. Add BLAST204
Natural varianti310T → S in strain: cv. Uk-2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702648 mRNA. Translation: ABG25052.1.
AY702649 mRNA. Translation: ABG25053.1.
AC079041 Genomic DNA. Translation: AAG50720.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31412.1.
BT002854 mRNA. Translation: AAO22671.1.
BT004390 mRNA. Translation: AAO42384.1.
PIRiA86443.
RefSeqiNP_174471.2. NM_102925.3.
UniGeneiAt.40252.

Genome annotation databases

EnsemblPlantsiAT1G31880.1; AT1G31880.1; AT1G31880.
GeneIDi840078.
GrameneiAT1G31880.1; AT1G31880.1; AT1G31880.
KEGGiath:AT1G31880.

Similar proteinsi

Entry informationi

Entry nameiBRX_ARATH
AccessioniPrimary (citable) accession number: Q17TI5
Secondary accession number(s): Q17TI6, Q84JB6, Q9C6S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 7, 2017
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families