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Q17ST2 (KCNA7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 7
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.7
Gene names
Name:Kcna7
Synonyms:Kcnc7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2. Ref.1 Ref.2 Ref.3

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Ref.1 Ref.2 Ref.3.

Tissue specificity

Detected in heart, skeletal muscle, brain, and pancreatic islet cells. Ref.1 Ref.2

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. [View classification]

Sequence caution

The sequence AAC12271.1 differs from that shown. Reason: Frameshift at several positions.

The sequence AAC23664.1 differs from that shown. Reason: Frameshift at several positions.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q17ST2-1)

Also known as: Kv1.7L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q17ST2-2)

Also known as: Kv1.7S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
Note: Produced by alternative initiation at Met-33 of isoform 1.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Potassium voltage-gated channel subfamily A member 7
PRO_0000308274

Regions

Transmembrane176 – 19621Helical; Name=Segment S1; Potential
Transmembrane242 – 26221Helical; Name=Segment S2; Potential
Transmembrane274 – 29421Helical; Name=Segment S3; Potential
Transmembrane309 – 32820Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane345 – 36521Helical; Name=Segment S5; Potential
Transmembrane406 – 42621Helical; Name=Segment S6; Potential
Motif391 – 3966Selectivity filter By similarity

Amino acid modifications

Lipidation2641S-palmitoyl cysteine Potential
Glycosylation2241N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 3232Missing in isoform 2.
VSP_028953

Experimental info

Sequence conflict861R → A in AAC12271. Ref.1
Sequence conflict1161V → L in AAX11185. Ref.2
Sequence conflict2181P → S in AAC12271. Ref.1
Sequence conflict2601R → H in AAC12271. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Kv1.7L) [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 80E92AB7697B6D2A

FASTA48953,948
        10         20         30         40         50         60 
MLFLPADTGH PTGVAAASGP HVRSPVARAV RAMEPRCPPP CGCCERLVLN VAGLRFETRA 

        70         80         90        100        110        120 
RTLGRFPDTL LGDPVRRSRF YDGARREYFF DRHRPSFDAV LYYYQSGGRL RRPAHVPLDV 

       130        140        150        160        170        180 
FLEEVSFYGL GAAALARLRE DEGCAVPPER PLPRRAFARQ LWLLFEFPES SQAARVLAVV 

       190        200        210        220        230        240 
SVLVILVSIV VFCLETLPDF RDDRDDPGLA PVAAATGPFL ARLNGSSPMP GAPPRQPFND 

       250        260        270        280        290        300 
PFFVVETLCI CWFSFELLVR LVACPSKAVF FKNVMNLIDF VAILPYFVAL GTELARQRGV 

       310        320        330        340        350        360 
GQPAMSLAIL RVIRLVRVFR IFKLSRHSKG LQILGQTLRA SMRELGLLIF FLFIGVVLFS 

       370        380        390        400        410        420 
SAVYFAEVDR VDTHFTSIPE SFWWAVVTMT TVGYGDMAPV TVGGKIVGSL CAIAGVLTIS 

       430        440        450        460        470        480 
LPVPVIVSNF SYFYHRETEG EEAGMYSHVD TQPCGTLEGK ANGGLVDSEV PELLPPLWPP 


AGKHMVTEV 

« Hide

Isoform 2 (Kv1.7S) [UniParc].

Checksum: 2D76208D10F1FAF2
Show »

FASTA45750,755

References

[1]"Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7."
Kalman K., Nguyen A., Tseng-Crank J., Dukes I.D., Chandy G., Hustad C.M., Copeland N.G., Jenkins N.A., Mohrenweiser H., Brandriff B., Cahalan M., Gutman G.A., Chandy K.G.
J. Biol. Chem. 273:5851-5857(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Molecular and functional differences between heart mKv1.7 channel isoforms."
Finol-Urdaneta R.K., Struever N., Terlau H.
J. Gen. Physiol. 128:133-145(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: NMRI.
Tissue: Heart and Skeletal muscle.
[3]"Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)."
Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V.
Eur. J. Hum. Genet. 10:36-43(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF032099 mRNA. Translation: AAC12271.1. Frameshift.
AF032101, AF032100 Genomic DNA. Translation: AAC23664.1. Frameshift.
AY779767 mRNA. Translation: AAX11185.1.
CCDSCCDS39951.1. [Q17ST2-1]
PIRS09047.
RefSeqNP_034726.2. NM_010596.2. [Q17ST2-1]
UniGeneMm.12955.

3D structure databases

ProteinModelPortalQ17ST2.
SMRQ17ST2. Positions 44-438.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY544.

Proteomic databases

PRIDEQ17ST2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107774; ENSMUSP00000103403; ENSMUSG00000038201. [Q17ST2-1]
GeneID16495.
KEGGmmu:16495.
UCSCuc009guz.1. mouse. [Q17ST2-1]

Organism-specific databases

CTD3743.
MGIMGI:96664. Kcna7.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00740000115291.
HOGENOMHOG000231015.
HOVERGENHBG052230.
KOK04880.
OMAAMEPRCP.
OrthoDBEOG7M0NRD.
PhylomeDBQ17ST2.
TreeFamTF313103.

Gene expression databases

BgeeQ17ST2.
GenevestigatorQ17ST2.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio289807.
PROQ17ST2.
SOURCESearch...

Entry information

Entry nameKCNA7_MOUSE
AccessionPrimary (citable) accession number: Q17ST2
Secondary accession number(s): O70259
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot