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Q17ST2

- KCNA7_MOUSE

UniProt

Q17ST2 - KCNA7_MOUSE

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Protein

Potassium voltage-gated channel subfamily A member 7

Gene

Kcna7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2.3 Publications

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 7
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.7
Gene namesi
Name:Kcna7
Synonyms:Kcnc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96664. Kcna7.

Subcellular locationi

Membrane 3 Publications; Multi-pass membrane protein 3 Publications

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Potassium voltage-gated channel subfamily A member 7PRO_0000308274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Lipidationi264 – 2641S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ17ST2.

Expressioni

Tissue specificityi

Detected in heart, skeletal muscle, brain, and pancreatic islet cells.2 Publications

Gene expression databases

BgeeiQ17ST2.
GenevestigatoriQ17ST2.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ17ST2.
SMRiQ17ST2. Positions 44-438.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei176 – 19621Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei309 – 32820Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei345 – 36521Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei406 – 42621Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi391 – 3966Selectivity filterBy similarity

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ17ST2.
KOiK04880.
OMAiAMEPRCP.
OrthoDBiEOG7M0NRD.
PhylomeDBiQ17ST2.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q17ST2-1) [UniParc]FASTAAdd to Basket

Also known as: Kv1.7L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFLPADTGH PTGVAAASGP HVRSPVARAV RAMEPRCPPP CGCCERLVLN
60 70 80 90 100
VAGLRFETRA RTLGRFPDTL LGDPVRRSRF YDGARREYFF DRHRPSFDAV
110 120 130 140 150
LYYYQSGGRL RRPAHVPLDV FLEEVSFYGL GAAALARLRE DEGCAVPPER
160 170 180 190 200
PLPRRAFARQ LWLLFEFPES SQAARVLAVV SVLVILVSIV VFCLETLPDF
210 220 230 240 250
RDDRDDPGLA PVAAATGPFL ARLNGSSPMP GAPPRQPFND PFFVVETLCI
260 270 280 290 300
CWFSFELLVR LVACPSKAVF FKNVMNLIDF VAILPYFVAL GTELARQRGV
310 320 330 340 350
GQPAMSLAIL RVIRLVRVFR IFKLSRHSKG LQILGQTLRA SMRELGLLIF
360 370 380 390 400
FLFIGVVLFS SAVYFAEVDR VDTHFTSIPE SFWWAVVTMT TVGYGDMAPV
410 420 430 440 450
TVGGKIVGSL CAIAGVLTIS LPVPVIVSNF SYFYHRETEG EEAGMYSHVD
460 470 480
TQPCGTLEGK ANGGLVDSEV PELLPPLWPP AGKHMVTEV
Length:489
Mass (Da):53,948
Last modified:October 23, 2007 - v2
Checksum:i80E92AB7697B6D2A
GO
Isoform 2 (identifier: Q17ST2-2) [UniParc]FASTAAdd to Basket

Also known as: Kv1.7S

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: Produced by alternative initiation at Met-33 of isoform 1.

Show »
Length:457
Mass (Da):50,755
Checksum:i2D76208D10F1FAF2
GO

Sequence cautioni

The sequence AAC12271.1 differs from that shown. Reason: Frameshift at several positions.
The sequence AAC23664.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861R → A in AAC12271. (PubMed:9488722)Curated
Sequence conflicti116 – 1161V → L in AAX11185. (PubMed:16801386)Curated
Sequence conflicti218 – 2181P → S in AAC12271. (PubMed:9488722)Curated
Sequence conflicti260 – 2601R → H in AAC12271. (PubMed:9488722)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_028953Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF032099 mRNA. Translation: AAC12271.1. Frameshift.
AF032101, AF032100 Genomic DNA. Translation: AAC23664.1. Frameshift.
AY779767 mRNA. Translation: AAX11185.1.
CCDSiCCDS39951.1. [Q17ST2-1]
PIRiS09047.
RefSeqiNP_034726.2. NM_010596.2. [Q17ST2-1]
UniGeneiMm.12955.

Genome annotation databases

EnsembliENSMUST00000107774; ENSMUSP00000103403; ENSMUSG00000038201. [Q17ST2-1]
GeneIDi16495.
KEGGimmu:16495.
UCSCiuc009guz.1. mouse. [Q17ST2-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF032099 mRNA. Translation: AAC12271.1 . Frameshift.
AF032101 , AF032100 Genomic DNA. Translation: AAC23664.1 . Frameshift.
AY779767 mRNA. Translation: AAX11185.1 .
CCDSi CCDS39951.1. [Q17ST2-1 ]
PIRi S09047.
RefSeqi NP_034726.2. NM_010596.2. [Q17ST2-1 ]
UniGenei Mm.12955.

3D structure databases

ProteinModelPortali Q17ST2.
SMRi Q17ST2. Positions 44-438.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 544.

Proteomic databases

PRIDEi Q17ST2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107774 ; ENSMUSP00000103403 ; ENSMUSG00000038201 . [Q17ST2-1 ]
GeneIDi 16495.
KEGGi mmu:16495.
UCSCi uc009guz.1. mouse. [Q17ST2-1 ]

Organism-specific databases

CTDi 3743.
MGIi MGI:96664. Kcna7.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi Q17ST2.
KOi K04880.
OMAi AMEPRCP.
OrthoDBi EOG7M0NRD.
PhylomeDBi Q17ST2.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289807.
PROi Q17ST2.
SOURCEi Search...

Gene expression databases

Bgeei Q17ST2.
Genevestigatori Q17ST2.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7."
    Kalman K., Nguyen A., Tseng-Crank J., Dukes I.D., Chandy G., Hustad C.M., Copeland N.G., Jenkins N.A., Mohrenweiser H., Brandriff B., Cahalan M., Gutman G.A., Chandy K.G.
    J. Biol. Chem. 273:5851-5857(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Molecular and functional differences between heart mKv1.7 channel isoforms."
    Finol-Urdaneta R.K., Struever N., Terlau H.
    J. Gen. Physiol. 128:133-145(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: NMRI.
    Tissue: Heart and Skeletal muscle.
  3. "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)."
    Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V.
    Eur. J. Hum. Genet. 10:36-43(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiKCNA7_MOUSE
AccessioniPrimary (citable) accession number: Q17ST2
Secondary accession number(s): O70259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3