Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q17ST2

- KCNA7_MOUSE

UniProt

Q17ST2 - KCNA7_MOUSE

Protein

Potassium voltage-gated channel subfamily A member 7

Gene

Kcna7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2.3 Publications

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 7
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv1.7
    Gene namesi
    Name:Kcna7
    Synonyms:Kcnc7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:96664. Kcna7.

    Subcellular locationi

    Membrane 3 Publications; Multi-pass membrane protein 3 Publications

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Potassium voltage-gated channel subfamily A member 7PRO_0000308274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Lipidationi264 – 2641S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ17ST2.

    Expressioni

    Tissue specificityi

    Detected in heart, skeletal muscle, brain, and pancreatic islet cells.2 Publications

    Gene expression databases

    BgeeiQ17ST2.
    GenevestigatoriQ17ST2.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ17ST2.
    SMRiQ17ST2. Positions 44-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei176 – 19621Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 32820Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei406 – 42621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi391 – 3966Selectivity filterBy similarity

    Domaini

    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115291.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    KOiK04880.
    OMAiAMEPRCP.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiQ17ST2.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q17ST2-1) [UniParc]FASTAAdd to Basket

    Also known as: Kv1.7L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLFLPADTGH PTGVAAASGP HVRSPVARAV RAMEPRCPPP CGCCERLVLN    50
    VAGLRFETRA RTLGRFPDTL LGDPVRRSRF YDGARREYFF DRHRPSFDAV 100
    LYYYQSGGRL RRPAHVPLDV FLEEVSFYGL GAAALARLRE DEGCAVPPER 150
    PLPRRAFARQ LWLLFEFPES SQAARVLAVV SVLVILVSIV VFCLETLPDF 200
    RDDRDDPGLA PVAAATGPFL ARLNGSSPMP GAPPRQPFND PFFVVETLCI 250
    CWFSFELLVR LVACPSKAVF FKNVMNLIDF VAILPYFVAL GTELARQRGV 300
    GQPAMSLAIL RVIRLVRVFR IFKLSRHSKG LQILGQTLRA SMRELGLLIF 350
    FLFIGVVLFS SAVYFAEVDR VDTHFTSIPE SFWWAVVTMT TVGYGDMAPV 400
    TVGGKIVGSL CAIAGVLTIS LPVPVIVSNF SYFYHRETEG EEAGMYSHVD 450
    TQPCGTLEGK ANGGLVDSEV PELLPPLWPP AGKHMVTEV 489
    Length:489
    Mass (Da):53,948
    Last modified:October 23, 2007 - v2
    Checksum:i80E92AB7697B6D2A
    GO
    Isoform 2 (identifier: Q17ST2-2) [UniParc]FASTAAdd to Basket

    Also known as: Kv1.7S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-32: Missing.

    Note: Produced by alternative initiation at Met-33 of isoform 1.

    Show »
    Length:457
    Mass (Da):50,755
    Checksum:i2D76208D10F1FAF2
    GO

    Sequence cautioni

    The sequence AAC12271.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAC23664.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861R → A in AAC12271. (PubMed:9488722)Curated
    Sequence conflicti116 – 1161V → L in AAX11185. (PubMed:16801386)Curated
    Sequence conflicti218 – 2181P → S in AAC12271. (PubMed:9488722)Curated
    Sequence conflicti260 – 2601R → H in AAC12271. (PubMed:9488722)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_028953Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF032099 mRNA. Translation: AAC12271.1. Frameshift.
    AF032101, AF032100 Genomic DNA. Translation: AAC23664.1. Frameshift.
    AY779767 mRNA. Translation: AAX11185.1.
    CCDSiCCDS39951.1. [Q17ST2-1]
    PIRiS09047.
    RefSeqiNP_034726.2. NM_010596.2. [Q17ST2-1]
    UniGeneiMm.12955.

    Genome annotation databases

    EnsembliENSMUST00000107774; ENSMUSP00000103403; ENSMUSG00000038201. [Q17ST2-1]
    GeneIDi16495.
    KEGGimmu:16495.
    UCSCiuc009guz.1. mouse. [Q17ST2-1]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF032099 mRNA. Translation: AAC12271.1 . Frameshift.
    AF032101 , AF032100 Genomic DNA. Translation: AAC23664.1 . Frameshift.
    AY779767 mRNA. Translation: AAX11185.1 .
    CCDSi CCDS39951.1. [Q17ST2-1 ]
    PIRi S09047.
    RefSeqi NP_034726.2. NM_010596.2. [Q17ST2-1 ]
    UniGenei Mm.12955.

    3D structure databases

    ProteinModelPortali Q17ST2.
    SMRi Q17ST2. Positions 44-438.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 544.

    Proteomic databases

    PRIDEi Q17ST2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107774 ; ENSMUSP00000103403 ; ENSMUSG00000038201 . [Q17ST2-1 ]
    GeneIDi 16495.
    KEGGi mmu:16495.
    UCSCi uc009guz.1. mouse. [Q17ST2-1 ]

    Organism-specific databases

    CTDi 3743.
    MGIi MGI:96664. Kcna7.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115291.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    KOi K04880.
    OMAi AMEPRCP.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi Q17ST2.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 289807.
    PROi Q17ST2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q17ST2.
    Genevestigatori Q17ST2.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7."
      Kalman K., Nguyen A., Tseng-Crank J., Dukes I.D., Chandy G., Hustad C.M., Copeland N.G., Jenkins N.A., Mohrenweiser H., Brandriff B., Cahalan M., Gutman G.A., Chandy K.G.
      J. Biol. Chem. 273:5851-5857(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Molecular and functional differences between heart mKv1.7 channel isoforms."
      Finol-Urdaneta R.K., Struever N., Terlau H.
      J. Gen. Physiol. 128:133-145(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: NMRI.
      Tissue: Heart and Skeletal muscle.
    3. "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)."
      Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V.
      Eur. J. Hum. Genet. 10:36-43(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiKCNA7_MOUSE
    AccessioniPrimary (citable) accession number: Q17ST2
    Secondary accession number(s): O70259
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3