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Protein

Lymphocyte antigen 6K

Gene

LY6K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell growth.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6K
Short name:
Ly-6K
Gene namesi
Name:LY6K
Synonyms:CO16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24225. LY6K.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54742.
OpenTargetsiENSG00000160886.
PharmGKBiPA134987940.

Polymorphism and mutation databases

BioMutaiLY6K.
DMDMi189028864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000033708418 – 138Lymphocyte antigen 6KAdd BLAST121
PropeptideiPRO_0000337085139 – 165Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Lipidationi138GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ17RY6.
MaxQBiQ17RY6.
PaxDbiQ17RY6.
PeptideAtlasiQ17RY6.
PRIDEiQ17RY6.

PTM databases

PhosphoSitePlusiQ17RY6.

Expressioni

Tissue specificityi

Specifically expressed in testis (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000160886.
CleanExiHS_LY6K.
ExpressionAtlasiQ17RY6. baseline and differential.
GenevisibleiQ17RY6. HS.

Organism-specific databases

HPAiCAB075742.
CAB075743.
HPA017770.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000453042.

Structurei

3D structure databases

ProteinModelPortaliQ17RY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 141UPAR/Ly6Add BLAST95

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG7H. Eukaryota.
ENOG411134J. LUCA.
GeneTreeiENSGT00520000056196.
HOGENOMiHOG000172423.
InParanoidiQ17RY6.
OMAiLEGPPIN.
OrthoDBiEOG091G11RE.
PhylomeDBiQ17RY6.
TreeFamiTF336908.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17RY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLALLLVV ALPRVWTDAN LTARQRDPED SQRTDEGDNR VWCHVCEREN
60 70 80 90 100
TFECQNPRRC KWTEPYCVIA AVKIFPRFFM VAKQCSAGCA AMERPKPEEK
110 120 130 140 150
RFLLEEPMPF FYLKCCKIRY CNLEGPPINS SVFKEYAGSM GESCGGLWLA
160
ILLLLASIAA GLSLS
Length:165
Mass (Da):18,673
Last modified:May 20, 2008 - v2
Checksum:iBA75B436BE91363D
GO
Isoform 2 (identifier: Q17RY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-105: KIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLE → TVLRWLCSDGETQARGEAVSPGRAHALLLPQVL
     106-165: Missing.

Note: No experimental confirmation available.
Show »
Length:105
Mass (Da):11,902
Checksum:iD2FEF4616469798C
GO

Sequence cautioni

The sequence AAH01291 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI17143 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI17145 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA04692 differs from that shown. Reason: Frameshift at positions 182 and 184.Curated
The sequence CAA04692 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW82311 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → Q in CAA04692 (Ref. 1) Curated1
Sequence conflicti41V → A in CAA04692 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04560273 – 105KIFPR…RFLLE → TVLRWLCSDGETQARGEAVS PGRAHALLLPQVL in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_045603106 – 165Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001348 mRNA. Translation: CAA04692.1. Sequence problems.
AC108002 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82311.1. Different initiation.
BC001291 mRNA. Translation: AAH01291.2. Different initiation.
BC117142 mRNA. Translation: AAI17143.1. Different initiation.
BC117144 mRNA. Translation: AAI17145.1. Different initiation.
AI740834 mRNA. No translation available.
CCDSiCCDS59114.1. [Q17RY6-2]
CCDS6385.2. [Q17RY6-1]
RefSeqiNP_001153826.1. NM_001160354.1.
NP_001153827.1. NM_001160355.1. [Q17RY6-2]
NP_059997.3. NM_017527.3. [Q17RY6-1]
UniGeneiHs.69517.
Hs.716823.

Genome annotation databases

EnsembliENST00000292430; ENSP00000292430; ENSG00000160886. [Q17RY6-1]
ENST00000519387; ENSP00000429695; ENSG00000160886. [Q17RY6-2]
GeneIDi54742.
KEGGihsa:54742.
UCSCiuc011ljv.3. human. [Q17RY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001348 mRNA. Translation: CAA04692.1. Sequence problems.
AC108002 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82311.1. Different initiation.
BC001291 mRNA. Translation: AAH01291.2. Different initiation.
BC117142 mRNA. Translation: AAI17143.1. Different initiation.
BC117144 mRNA. Translation: AAI17145.1. Different initiation.
AI740834 mRNA. No translation available.
CCDSiCCDS59114.1. [Q17RY6-2]
CCDS6385.2. [Q17RY6-1]
RefSeqiNP_001153826.1. NM_001160354.1.
NP_001153827.1. NM_001160355.1. [Q17RY6-2]
NP_059997.3. NM_017527.3. [Q17RY6-1]
UniGeneiHs.69517.
Hs.716823.

3D structure databases

ProteinModelPortaliQ17RY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000453042.

PTM databases

PhosphoSitePlusiQ17RY6.

Polymorphism and mutation databases

BioMutaiLY6K.
DMDMi189028864.

Proteomic databases

EPDiQ17RY6.
MaxQBiQ17RY6.
PaxDbiQ17RY6.
PeptideAtlasiQ17RY6.
PRIDEiQ17RY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292430; ENSP00000292430; ENSG00000160886. [Q17RY6-1]
ENST00000519387; ENSP00000429695; ENSG00000160886. [Q17RY6-2]
GeneIDi54742.
KEGGihsa:54742.
UCSCiuc011ljv.3. human. [Q17RY6-1]

Organism-specific databases

CTDi54742.
DisGeNETi54742.
GeneCardsiLY6K.
HGNCiHGNC:24225. LY6K.
HPAiCAB075742.
CAB075743.
HPA017770.
MIMi615093. gene.
neXtProtiNX_Q17RY6.
OpenTargetsiENSG00000160886.
PharmGKBiPA134987940.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG7H. Eukaryota.
ENOG411134J. LUCA.
GeneTreeiENSGT00520000056196.
HOGENOMiHOG000172423.
InParanoidiQ17RY6.
OMAiLEGPPIN.
OrthoDBiEOG091G11RE.
PhylomeDBiQ17RY6.
TreeFamiTF336908.

Miscellaneous databases

GenomeRNAii54742.
PROiQ17RY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160886.
CleanExiHS_LY6K.
ExpressionAtlasiQ17RY6. baseline and differential.
GenevisibleiQ17RY6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLY6K_HUMAN
AccessioniPrimary (citable) accession number: Q17RY6
Secondary accession number(s): G3V116, O15227, Q9BVD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.