Q17RY0 (CPEB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytoplasmic polyadenylation element-binding protein 4
Short name=CPE-BP4
Short name=CPE-binding protein 4
Short name=hCPEB-4

Gene names

Name:	CPEB4
Synonyms:	KIAA1673

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	729 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the RRM CPEB family. Contains 2 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	synapse Inferred from electronic annotation. Source: Compara
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q17RY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q17RY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     403-419: Missing.

Isoform 3 (identifier: Q17RY0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.
     404-428: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 729	729	Cytoplasmic polyadenylation element-binding protein 4		PRO_0000269264
Regions
	Domain	472 – 563	92	RRM 1
	Domain	580 – 662	83	RRM 2
	Compositional bias	232 – 246	15	His-rich
	Compositional bias	302 – 311	10	Poly-Gly
Amino acid modifications
	Modified residue	252	1	Phosphoserine Ref.5 Ref.6
	Modified residue	255	1	Phosphoserine Ref.5 Ref.6
	Modified residue	326	1	Phosphothreonine Ref.5
	Modified residue	330	1	Phosphoserine Ref.6
	Modified residue	332	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 382	382	Missing in isoform 3.		VSP_022040
	Alternative sequence	403 – 419	17	Missing in isoform 2.		VSP_022041
	Alternative sequence	404 – 428	25	Missing in isoform 3.		VSP_022042
Experimental info
	Sequence conflict	228	1	P → L in CAD98072. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: B71AAB0650E8CB13	FASTA	729	80,152
	10 20 30 40 50 60 MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA ANGSSAGSAW 70 80 90 100 110 120 LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP GQEAGILPET EKAKSEENQG 130 140 150 160 170 180 DNSSENGNGK EKIRIESPVL TGFDYQEATG LGTSTQPLTS SASSLTGFSN WSAAIAPSSS 190 200 210 220 230 240 TIINEDASFF HQGGVPAASA NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ 250 260 270 280 290 300 HHHSQHQQQR RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS 310 320 330 340 350 360 PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR PSSAFAPKSW 370 380 390 400 410 420 MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT IKGRLNYSYP GSDSSLLINA 430 440 450 460 470 480 RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH SGLGSPHCFS HQNGERVERY SRKVFVGGLP 490 500 510 520 530 540 PDIDEDEITA SFRRFGPLIV DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG 550 560 570 580 590 600 KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM 610 620 630 640 650 660 DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE IDKRVEVKPY 670 680 690 700 710 720 VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA IHSRAGREFH KPLVKEGGDR PRHISFRWN
	Isoform 2 [UniParc]. Checksum: 6F001427FE1FB724	FASTA	712	78,314
	10 20 30 40 50 60 MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA ANGSSAGSAW 70 80 90 100 110 120 LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP GQEAGILPET EKAKSEENQG 130 140 150 160 170 180 DNSSENGNGK EKIRIESPVL TGFDYQEATG LGTSTQPLTS SASSLTGFSN WSAAIAPSSS 190 200 210 220 230 240 TIINEDASFF HQGGVPAASA NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ 250 260 270 280 290 300 HHHSQHQQQR RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS 310 320 330 340 350 360 PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR PSSAFAPKSW 370 380 390 400 410 420 MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT IKARTYGRRR GQSSLFPMED 430 440 450 460 470 480 GFLDDGRGDQ PLHSGLGSPH CFSHQNGERV ERYSRKVFVG GLPPDIDEDE ITASFRRFGP 490 500 510 520 530 540 LIVDWPHKAE SKSYFPPKGY AFLLFQDESS VQALIDACIE EDGKLYLCVS SPTIKDKPVQ 550 560 570 580 590 600 IRPWNLSDSD FVMDGSQPLD PRKTIFVGGV PRPLRAVELA MIMDRLYGGV CYAGIDTDPE 610 620 630 640 650 660 LKYPKGAGRV AFSNQQSYIA AISARFVQLQ HGEIDKRVEV KPYVLDDQLC DECQGARCGG 670 680 690 700 710 KFAPFFCANV TCLQYYCEYC WAAIHSRAGR EFHKPLVKEG GDRPRHISFR WN
	Isoform 3 [UniParc]. Checksum: F366DD034761699C	FASTA	322	36,212
	10 20 30 40 50 60 MHSLESSLID IMRAENDTIK GQSSLFPMED GFLDDGRGDQ PLHSGLGSPH CFSHQNGERV 70 80 90 100 110 120 ERYSRKVFVG GLPPDIDEDE ITASFRRFGP LIVDWPHKAE SKSYFPPKGY AFLLFQDESS 130 140 150 160 170 180 VQALIDACIE EDGKLYLCVS SPTIKDKPVQ IRPWNLSDSD FVMDGSQPLD PRKTIFVGGV 190 200 210 220 230 240 PRPLRAVELA MIMDRLYGGV CYAGIDTDPE LKYPKGAGRV AFSNQQSYIA AISARFVQLQ 250 260 270 280 290 300 HGEIDKRVEV KPYVLDDQLC DECQGARCGG KFAPFFCANV TCLQYYCEYC WAAIHSRAGR 310 320 EFHKPLVKEG GDRPRHISFR WN

References

[1]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain and Lymphoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255 AND THR-326, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255; SER-330 AND SER-332, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051460 mRNA. Translation: BAB21764.1. BX538213 mRNA. Translation: CAD98072.1. CH471062 Genomic DNA. Translation: EAW61392.1. BC036899 mRNA. Translation: AAH36899.1. BC117150 mRNA. Translation: AAI17151.1. BC143958 mRNA. Translation: AAI43959.1.
IPI	IPI00181719. IPI00375652. IPI00386558.
RefSeq	NP_085130.2. NM_030627.2.
UniGene	Hs.127126.
3D structure databases
ProteinModelPortal	Q17RY0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q17RY0. 1 interaction.
PTM databases
PhosphoSite	Q17RY0.
Polymorphism databases
DMDM	119368635.
Proteomic databases
PaxDb	Q17RY0.
PRIDE	Q17RY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265085; ENSP00000265085; ENSG00000113742. ENST00000334035; ENSP00000334533; ENSG00000113742. ENST00000517880; ENSP00000427990; ENSG00000113742.
GeneID	80315.
KEGG	hsa:80315.
UCSC	uc003mcs.4. human. uc003mcu.4. human. uc010jjv.3. human.
Organism-specific databases
CTD	80315.
GeneCards	GC05P173315.
HGNC	HGNC:21747. CPEB4.
HPA	HPA038392. HPA038394.
MIM	610607. gene.
neXtProt	NX_Q17RY0.
PharmGKB	PA134869176.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240295.
HOVERGEN	HBG058010.
InParanoid	Q17RY0.
OMA	AHNIQDE.
OrthoDB	EOG4JM7P9.
PhylomeDB	Q17RY0.
Gene expression databases
ArrayExpress	Q17RY0.
Bgee	Q17RY0.
CleanEx	HS_CPEB4.
Genevestigator	Q17RY0.
Family and domain databases
Gene3D	3.30.70.330. 3 hits.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Pfam	PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 2 hits. [Graphical view]
PROSITE	PS50102. RRM. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CPEB4. human.
GenomeRNAi	80315.
NextBio	70816.
SOURCE	Search...

Entry information

Entry name

CPEB4_HUMAN

Accession

Primary (citable) accession number: Q17RY0
Secondary accession number(s): B7ZLQ7 , Q7Z310, Q8N405, Q9C0J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 25, 2006
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.