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Protein

Cytoplasmic polyadenylation element-binding protein 4

Gene

CPEB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein which, in contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 4
Short name:
CPE-BP4
Short name:
CPE-binding protein 4
Short name:
hCPEB-4
Gene namesi
Name:CPEB4
Synonyms:KIAA1673
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:21747. CPEB4.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • messenger ribonucleoprotein complex Source: GO_Central
  • neuron projection Source: GO_Central
  • nucleus Source: UniProtKB
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-KW
  • synapse Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi80315.
OpenTargetsiENSG00000113742.
PharmGKBiPA134869176.

Polymorphism and mutation databases

BioMutaiCPEB4.
DMDMi119368635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692641 – 729Cytoplasmic polyadenylation element-binding protein 4Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei326PhosphothreonineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ17RY0.
PaxDbiQ17RY0.
PeptideAtlasiQ17RY0.
PRIDEiQ17RY0.

PTM databases

iPTMnetiQ17RY0.
PhosphoSitePlusiQ17RY0.

Expressioni

Gene expression databases

BgeeiENSG00000113742.
CleanExiHS_CPEB4.
ExpressionAtlasiQ17RY0. baseline and differential.
GenevisibleiQ17RY0. HS.

Organism-specific databases

HPAiHPA038392.
HPA038394.

Interactioni

Subunit structurei

Interacts with TOB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TOB1P506162EBI-2848203,EBI-723281

Protein-protein interaction databases

BioGridi123228. 4 interactors.
IntActiQ17RY0. 6 interactors.
MINTiMINT-4826077.
STRINGi9606.ENSP00000265085.

Structurei

Secondary structure

1729
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi384 – 391Combined sources8
Beta strandi472 – 477Combined sources6
Helixi485 – 491Combined sources7
Helixi492 – 495Combined sources4
Beta strandi499 – 501Combined sources3
Turni507 – 509Combined sources3
Beta strandi514 – 516Combined sources3
Beta strandi518 – 521Combined sources4
Helixi527 – 533Combined sources7
Beta strandi534 – 538Combined sources5
Beta strandi541 – 544Combined sources4
Beta strandi556 – 560Combined sources5
Beta strandi563 – 572Combined sources10
Beta strandi580 – 586Combined sources7
Beta strandi589 – 591Combined sources3
Helixi593 – 603Combined sources11
Beta strandi607 – 615Combined sources9
Turni616 – 619Combined sources4
Beta strandi620 – 631Combined sources12
Helixi632 – 638Combined sources7
Beta strandi639 – 643Combined sources5
Beta strandi645 – 648Combined sources4
Beta strandi651 – 653Combined sources3
Beta strandi656 – 659Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKINMR-A460-662[»]
2MKJNMR-A460-662[»]
5DIFX-ray2.09D379-393[»]
ProteinModelPortaliQ17RY0.
SMRiQ17RY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini472 – 563RRM 1PROSITE-ProRule annotationAdd BLAST92
Domaini580 – 662RRM 2PROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi232 – 246His-richAdd BLAST15
Compositional biasi302 – 311Poly-Gly10

Sequence similaritiesi

Belongs to the RRM CPEB family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0129. Eukaryota.
ENOG410Y1XZ. LUCA.
GeneTreeiENSGT00390000012886.
HOVERGENiHBG058010.
InParanoidiQ17RY0.
KOiK02602.
OMAiTGFNNWS.
OrthoDBiEOG091G0AO9.
PhylomeDBiQ17RY0.
TreeFamiTF317658.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17RY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA
60 70 80 90 100
ANGSSAGSAW LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP
110 120 130 140 150
GQEAGILPET EKAKSEENQG DNSSENGNGK EKIRIESPVL TGFDYQEATG
160 170 180 190 200
LGTSTQPLTS SASSLTGFSN WSAAIAPSSS TIINEDASFF HQGGVPAASA
210 220 230 240 250
NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ HHHSQHQQQR
260 270 280 290 300
RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS
310 320 330 340 350
PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR
360 370 380 390 400
PSSAFAPKSW MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT
410 420 430 440 450
IKGRLNYSYP GSDSSLLINA RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH
460 470 480 490 500
SGLGSPHCFS HQNGERVERY SRKVFVGGLP PDIDEDEITA SFRRFGPLIV
510 520 530 540 550
DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG KLYLCVSSPT
560 570 580 590 600
IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM
610 620 630 640 650
DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE
660 670 680 690 700
IDKRVEVKPY VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA
710 720
IHSRAGREFH KPLVKEGGDR PRHISFRWN
Length:729
Mass (Da):80,152
Last modified:July 25, 2006 - v1
Checksum:iB71AAB0650E8CB13
GO
Isoform 2 (identifier: Q17RY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-419: Missing.

Show »
Length:712
Mass (Da):78,314
Checksum:i6F001427FE1FB724
GO
Isoform 3 (identifier: Q17RY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.
     404-428: Missing.

Show »
Length:322
Mass (Da):36,212
Checksum:iF366DD034761699C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228P → L in CAD98072 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0220401 – 382Missing in isoform 3. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_022041403 – 419Missing in isoform 2. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_022042404 – 428Missing in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051460 mRNA. Translation: BAB21764.1.
BX538213 mRNA. Translation: CAD98072.1.
CH471062 Genomic DNA. Translation: EAW61392.1.
BC036899 mRNA. Translation: AAH36899.1.
BC117150 mRNA. Translation: AAI17151.1.
BC143958 mRNA. Translation: AAI43959.1.
CCDSiCCDS4390.1. [Q17RY0-1]
CCDS78086.1. [Q17RY0-2]
CCDS83044.1. [Q17RY0-3]
RefSeqiNP_001295118.1. NM_001308189.1. [Q17RY0-2]
NP_001295120.1. NM_001308191.1.
NP_001295121.1. NM_001308192.1.
NP_001295122.1. NM_001308193.1. [Q17RY0-3]
NP_085130.2. NM_030627.3. [Q17RY0-1]
UniGeneiHs.127126.
Hs.127874.

Genome annotation databases

EnsembliENST00000265085; ENSP00000265085; ENSG00000113742. [Q17RY0-1]
ENST00000334035; ENSP00000334533; ENSG00000113742. [Q17RY0-2]
ENST00000517880; ENSP00000427990; ENSG00000113742. [Q17RY0-3]
GeneIDi80315.
KEGGihsa:80315.
UCSCiuc003mcs.5. human. [Q17RY0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051460 mRNA. Translation: BAB21764.1.
BX538213 mRNA. Translation: CAD98072.1.
CH471062 Genomic DNA. Translation: EAW61392.1.
BC036899 mRNA. Translation: AAH36899.1.
BC117150 mRNA. Translation: AAI17151.1.
BC143958 mRNA. Translation: AAI43959.1.
CCDSiCCDS4390.1. [Q17RY0-1]
CCDS78086.1. [Q17RY0-2]
CCDS83044.1. [Q17RY0-3]
RefSeqiNP_001295118.1. NM_001308189.1. [Q17RY0-2]
NP_001295120.1. NM_001308191.1.
NP_001295121.1. NM_001308192.1.
NP_001295122.1. NM_001308193.1. [Q17RY0-3]
NP_085130.2. NM_030627.3. [Q17RY0-1]
UniGeneiHs.127126.
Hs.127874.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKINMR-A460-662[»]
2MKJNMR-A460-662[»]
5DIFX-ray2.09D379-393[»]
ProteinModelPortaliQ17RY0.
SMRiQ17RY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123228. 4 interactors.
IntActiQ17RY0. 6 interactors.
MINTiMINT-4826077.
STRINGi9606.ENSP00000265085.

PTM databases

iPTMnetiQ17RY0.
PhosphoSitePlusiQ17RY0.

Polymorphism and mutation databases

BioMutaiCPEB4.
DMDMi119368635.

Proteomic databases

MaxQBiQ17RY0.
PaxDbiQ17RY0.
PeptideAtlasiQ17RY0.
PRIDEiQ17RY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265085; ENSP00000265085; ENSG00000113742. [Q17RY0-1]
ENST00000334035; ENSP00000334533; ENSG00000113742. [Q17RY0-2]
ENST00000517880; ENSP00000427990; ENSG00000113742. [Q17RY0-3]
GeneIDi80315.
KEGGihsa:80315.
UCSCiuc003mcs.5. human. [Q17RY0-1]

Organism-specific databases

CTDi80315.
DisGeNETi80315.
GeneCardsiCPEB4.
HGNCiHGNC:21747. CPEB4.
HPAiHPA038392.
HPA038394.
MIMi610607. gene.
neXtProtiNX_Q17RY0.
OpenTargetsiENSG00000113742.
PharmGKBiPA134869176.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0129. Eukaryota.
ENOG410Y1XZ. LUCA.
GeneTreeiENSGT00390000012886.
HOVERGENiHBG058010.
InParanoidiQ17RY0.
KOiK02602.
OMAiTGFNNWS.
OrthoDBiEOG091G0AO9.
PhylomeDBiQ17RY0.
TreeFamiTF317658.

Miscellaneous databases

ChiTaRSiCPEB4. human.
GenomeRNAii80315.
PROiQ17RY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113742.
CleanExiHS_CPEB4.
ExpressionAtlasiQ17RY0. baseline and differential.
GenevisibleiQ17RY0. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPEB4_HUMAN
AccessioniPrimary (citable) accession number: Q17RY0
Secondary accession number(s): B7ZLQ7
, Q7Z310, Q8N405, Q9C0J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.