Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytoplasmic polyadenylation element-binding protein 4

Gene

CPEB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. cellular response to amino acid stimulus Source: UniProtKB
  2. cellular response to decreased oxygen levels Source: UniProtKB
  3. cellular response to glucose starvation Source: UniProtKB
  4. ionotropic glutamate receptor signaling pathway Source: UniProtKB
  5. negative regulation of neuron apoptotic process Source: UniProtKB
  6. response to ischemia Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 4
Short name:
CPE-BP4
Short name:
CPE-binding protein 4
Short name:
hCPEB-4
Gene namesi
Name:CPEB4
Synonyms:KIAA1673
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:21747. CPEB4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. dendrite Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. postsynaptic density Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869176.

Polymorphism and mutation databases

BioMutaiCPEB4.
DMDMi119368635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Cytoplasmic polyadenylation element-binding protein 4PRO_0000269264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971Phosphoserine1 Publication
Modified residuei99 – 991Phosphoserine1 Publication
Modified residuei137 – 1371Phosphoserine1 Publication
Modified residuei252 – 2521Phosphoserine2 Publications
Modified residuei255 – 2551Phosphoserine2 Publications
Modified residuei326 – 3261Phosphothreonine1 Publication
Modified residuei330 – 3301Phosphoserine1 Publication
Modified residuei332 – 3321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ17RY0.
PaxDbiQ17RY0.
PRIDEiQ17RY0.

PTM databases

PhosphoSiteiQ17RY0.

Expressioni

Gene expression databases

BgeeiQ17RY0.
CleanExiHS_CPEB4.
ExpressionAtlasiQ17RY0. baseline and differential.
GenevestigatoriQ17RY0.

Organism-specific databases

HPAiHPA038392.
HPA038394.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TOB1P506162EBI-2848203,EBI-723281

Protein-protein interaction databases

BioGridi123228. 4 interactions.
IntActiQ17RY0. 3 interactions.
MINTiMINT-4826077.
STRINGi9606.ENSP00000265085.

Structurei

Secondary structure

1
729
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi472 – 4776Combined sources
Helixi485 – 4917Combined sources
Helixi492 – 4954Combined sources
Beta strandi499 – 5013Combined sources
Turni507 – 5093Combined sources
Beta strandi514 – 5163Combined sources
Beta strandi518 – 5214Combined sources
Helixi527 – 5337Combined sources
Beta strandi534 – 5385Combined sources
Beta strandi541 – 5444Combined sources
Beta strandi556 – 5605Combined sources
Beta strandi563 – 57210Combined sources
Beta strandi580 – 5867Combined sources
Beta strandi589 – 5913Combined sources
Helixi593 – 60311Combined sources
Beta strandi607 – 6159Combined sources
Turni616 – 6194Combined sources
Beta strandi620 – 63112Combined sources
Helixi632 – 6387Combined sources
Beta strandi639 – 6435Combined sources
Beta strandi645 – 6484Combined sources
Beta strandi651 – 6533Combined sources
Beta strandi656 – 6594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MKINMR-A460-662[»]
2MKJNMR-A460-661[»]
ProteinModelPortaliQ17RY0.
SMRiQ17RY0. Positions 460-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini472 – 56392RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini580 – 66283RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 24615His-richAdd
BLAST
Compositional biasi302 – 31110Poly-Gly

Sequence similaritiesi

Belongs to the RRM CPEB family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG240295.
GeneTreeiENSGT00390000012886.
HOVERGENiHBG058010.
InParanoidiQ17RY0.
KOiK02602.
OMAiTGFNNWS.
OrthoDBiEOG7X3QR2.
PhylomeDBiQ17RY0.
TreeFamiTF317658.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17RY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA
60 70 80 90 100
ANGSSAGSAW LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP
110 120 130 140 150
GQEAGILPET EKAKSEENQG DNSSENGNGK EKIRIESPVL TGFDYQEATG
160 170 180 190 200
LGTSTQPLTS SASSLTGFSN WSAAIAPSSS TIINEDASFF HQGGVPAASA
210 220 230 240 250
NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ HHHSQHQQQR
260 270 280 290 300
RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS
310 320 330 340 350
PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR
360 370 380 390 400
PSSAFAPKSW MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT
410 420 430 440 450
IKGRLNYSYP GSDSSLLINA RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH
460 470 480 490 500
SGLGSPHCFS HQNGERVERY SRKVFVGGLP PDIDEDEITA SFRRFGPLIV
510 520 530 540 550
DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG KLYLCVSSPT
560 570 580 590 600
IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM
610 620 630 640 650
DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE
660 670 680 690 700
IDKRVEVKPY VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA
710 720
IHSRAGREFH KPLVKEGGDR PRHISFRWN
Length:729
Mass (Da):80,152
Last modified:July 25, 2006 - v1
Checksum:iB71AAB0650E8CB13
GO
Isoform 2 (identifier: Q17RY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-419: Missing.

Show »
Length:712
Mass (Da):78,314
Checksum:i6F001427FE1FB724
GO
Isoform 3 (identifier: Q17RY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.
     404-428: Missing.

Show »
Length:322
Mass (Da):36,212
Checksum:iF366DD034761699C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281P → L in CAD98072 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 382382Missing in isoform 3. 1 PublicationVSP_022040Add
BLAST
Alternative sequencei403 – 41917Missing in isoform 2. 2 PublicationsVSP_022041Add
BLAST
Alternative sequencei404 – 42825Missing in isoform 3. 1 PublicationVSP_022042Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051460 mRNA. Translation: BAB21764.1.
BX538213 mRNA. Translation: CAD98072.1.
CH471062 Genomic DNA. Translation: EAW61392.1.
BC036899 mRNA. Translation: AAH36899.1.
BC117150 mRNA. Translation: AAI17151.1.
BC143958 mRNA. Translation: AAI43959.1.
CCDSiCCDS4390.1. [Q17RY0-1]
RefSeqiNP_085130.2. NM_030627.2. [Q17RY0-1]
XP_005266052.1. XM_005265995.1. [Q17RY0-2]
UniGeneiHs.127126.

Genome annotation databases

EnsembliENST00000265085; ENSP00000265085; ENSG00000113742. [Q17RY0-1]
ENST00000334035; ENSP00000334533; ENSG00000113742. [Q17RY0-2]
ENST00000517880; ENSP00000427990; ENSG00000113742. [Q17RY0-3]
GeneIDi80315.
KEGGihsa:80315.
UCSCiuc003mcs.4. human. [Q17RY0-1]
uc003mcu.4. human. [Q17RY0-3]
uc010jjv.3. human. [Q17RY0-2]

Polymorphism and mutation databases

BioMutaiCPEB4.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051460 mRNA. Translation: BAB21764.1.
BX538213 mRNA. Translation: CAD98072.1.
CH471062 Genomic DNA. Translation: EAW61392.1.
BC036899 mRNA. Translation: AAH36899.1.
BC117150 mRNA. Translation: AAI17151.1.
BC143958 mRNA. Translation: AAI43959.1.
CCDSiCCDS4390.1. [Q17RY0-1]
RefSeqiNP_085130.2. NM_030627.2. [Q17RY0-1]
XP_005266052.1. XM_005265995.1. [Q17RY0-2]
UniGeneiHs.127126.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MKINMR-A460-662[»]
2MKJNMR-A460-661[»]
ProteinModelPortaliQ17RY0.
SMRiQ17RY0. Positions 460-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123228. 4 interactions.
IntActiQ17RY0. 3 interactions.
MINTiMINT-4826077.
STRINGi9606.ENSP00000265085.

PTM databases

PhosphoSiteiQ17RY0.

Polymorphism and mutation databases

BioMutaiCPEB4.
DMDMi119368635.

Proteomic databases

MaxQBiQ17RY0.
PaxDbiQ17RY0.
PRIDEiQ17RY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265085; ENSP00000265085; ENSG00000113742. [Q17RY0-1]
ENST00000334035; ENSP00000334533; ENSG00000113742. [Q17RY0-2]
ENST00000517880; ENSP00000427990; ENSG00000113742. [Q17RY0-3]
GeneIDi80315.
KEGGihsa:80315.
UCSCiuc003mcs.4. human. [Q17RY0-1]
uc003mcu.4. human. [Q17RY0-3]
uc010jjv.3. human. [Q17RY0-2]

Organism-specific databases

CTDi80315.
GeneCardsiGC05P173315.
HGNCiHGNC:21747. CPEB4.
HPAiHPA038392.
HPA038394.
MIMi610607. gene.
neXtProtiNX_Q17RY0.
PharmGKBiPA134869176.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG240295.
GeneTreeiENSGT00390000012886.
HOVERGENiHBG058010.
InParanoidiQ17RY0.
KOiK02602.
OMAiTGFNNWS.
OrthoDBiEOG7X3QR2.
PhylomeDBiQ17RY0.
TreeFamiTF317658.

Miscellaneous databases

ChiTaRSiCPEB4. human.
GenomeRNAii80315.
NextBioi70816.
PROiQ17RY0.
SOURCEiSearch...

Gene expression databases

BgeeiQ17RY0.
CleanExiHS_CPEB4.
ExpressionAtlasiQ17RY0. baseline and differential.
GenevestigatoriQ17RY0.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Lymphoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255 AND THR-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255; SER-330 AND SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-99 AND SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCPEB4_HUMAN
AccessioniPrimary (citable) accession number: Q17RY0
Secondary accession number(s): B7ZLQ7
, Q7Z310, Q8N405, Q9C0J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: April 29, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.