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Q17RY0 (CPEB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytoplasmic polyadenylation element-binding protein 4

Short name=CPE-BP4
Short name=CPE-binding protein 4
Short name=hCPEB-4
Gene names
Name:CPEB4
Synonyms:KIAA1673
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length729 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the RRM CPEB family.

Contains 2 RRM (RNA recognition motif) domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TOB1P506162EBI-2848203,EBI-723281

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q17RY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q17RY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     403-419: Missing.
Isoform 3 (identifier: Q17RY0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.
     404-428: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 729729Cytoplasmic polyadenylation element-binding protein 4
PRO_0000269264

Regions

Domain472 – 56392RRM 1
Domain580 – 66283RRM 2
Compositional bias232 – 24615His-rich
Compositional bias302 – 31110Poly-Gly

Amino acid modifications

Modified residue971Phosphoserine By similarity
Modified residue2521Phosphoserine Ref.5 Ref.6
Modified residue2551Phosphoserine Ref.5 Ref.6
Modified residue3261Phosphothreonine Ref.5
Modified residue3301Phosphoserine Ref.6
Modified residue3321Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 382382Missing in isoform 3.
VSP_022040
Alternative sequence403 – 41917Missing in isoform 2.
VSP_022041
Alternative sequence404 – 42825Missing in isoform 3.
VSP_022042

Experimental info

Sequence conflict2281P → L in CAD98072. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: B71AAB0650E8CB13

FASTA72980,152
        10         20         30         40         50         60 
MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA ANGSSAGSAW 

        70         80         90        100        110        120 
LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP GQEAGILPET EKAKSEENQG 

       130        140        150        160        170        180 
DNSSENGNGK EKIRIESPVL TGFDYQEATG LGTSTQPLTS SASSLTGFSN WSAAIAPSSS 

       190        200        210        220        230        240 
TIINEDASFF HQGGVPAASA NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ 

       250        260        270        280        290        300 
HHHSQHQQQR RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS 

       310        320        330        340        350        360 
PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR PSSAFAPKSW 

       370        380        390        400        410        420 
MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT IKGRLNYSYP GSDSSLLINA 

       430        440        450        460        470        480 
RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH SGLGSPHCFS HQNGERVERY SRKVFVGGLP 

       490        500        510        520        530        540 
PDIDEDEITA SFRRFGPLIV DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG 

       550        560        570        580        590        600 
KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM 

       610        620        630        640        650        660 
DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE IDKRVEVKPY 

       670        680        690        700        710        720 
VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA IHSRAGREFH KPLVKEGGDR 


PRHISFRWN 

« Hide

Isoform 2 [UniParc].

Checksum: 6F001427FE1FB724
Show »

FASTA71278,314
Isoform 3 [UniParc].

Checksum: F366DD034761699C
Show »

FASTA32236,212

References

[1]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain and Lymphoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255 AND THR-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255; SER-330 AND SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051460 mRNA. Translation: BAB21764.1.
BX538213 mRNA. Translation: CAD98072.1.
CH471062 Genomic DNA. Translation: EAW61392.1.
BC036899 mRNA. Translation: AAH36899.1.
BC117150 mRNA. Translation: AAI17151.1.
BC143958 mRNA. Translation: AAI43959.1.
RefSeqNP_085130.2. NM_030627.2.
XP_005266052.1. XM_005265995.1.
UniGeneHs.127126.

3D structure databases

ProteinModelPortalQ17RY0.
SMRQ17RY0. Positions 472-720.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123228. 3 interactions.
IntActQ17RY0. 3 interactions.
MINTMINT-4826077.
STRING9606.ENSP00000265085.

PTM databases

PhosphoSiteQ17RY0.

Polymorphism databases

DMDM119368635.

Proteomic databases

PaxDbQ17RY0.
PRIDEQ17RY0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265085; ENSP00000265085; ENSG00000113742. [Q17RY0-1]
ENST00000334035; ENSP00000334533; ENSG00000113742. [Q17RY0-2]
ENST00000517880; ENSP00000427990; ENSG00000113742. [Q17RY0-3]
GeneID80315.
KEGGhsa:80315.
UCSCuc003mcs.4. human. [Q17RY0-1]
uc003mcu.4. human. [Q17RY0-3]
uc010jjv.3. human. [Q17RY0-2]

Organism-specific databases

CTD80315.
GeneCardsGC05P173315.
HGNCHGNC:21747. CPEB4.
HPAHPA038392.
HPA038394.
MIM610607. gene.
neXtProtNX_Q17RY0.
PharmGKBPA134869176.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240295.
HOVERGENHBG058010.
InParanoidQ17RY0.
OMAFQHHHNQ.
OrthoDBEOG7X3QR2.
PhylomeDBQ17RY0.
TreeFamTF317658.

Gene expression databases

ArrayExpressQ17RY0.
BgeeQ17RY0.
CleanExHS_CPEB4.
GenevestigatorQ17RY0.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 2 hits.
[Graphical view]
PROSITEPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCPEB4. human.
GenomeRNAi80315.
NextBio70816.
PROQ17RY0.
SOURCESearch...

Entry information

Entry nameCPEB4_HUMAN
AccessionPrimary (citable) accession number: Q17RY0
Secondary accession number(s): B7ZLQ7 expand/collapse secondary AC list , Q7Z310, Q8N405, Q9C0J0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM