Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q17RY0

- CPEB4_HUMAN

UniProt

Q17RY0 - CPEB4_HUMAN

Protein

Cytoplasmic polyadenylation element-binding protein 4

Gene

CPEB4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to amino acid stimulus Source: UniProtKB
    2. cellular response to decreased oxygen levels Source: UniProtKB
    3. cellular response to glucose starvation Source: UniProtKB
    4. ionotropic glutamate receptor signaling pathway Source: UniProtKB
    5. negative regulation of neuron apoptotic process Source: UniProtKB
    6. response to ischemia Source: UniProtKB

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 4
    Short name:
    CPE-BP4
    Short name:
    CPE-binding protein 4
    Short name:
    hCPEB-4
    Gene namesi
    Name:CPEB4
    Synonyms:KIAA1673
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:21747. CPEB4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. dendrite Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. postsynaptic density Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869176.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Cytoplasmic polyadenylation element-binding protein 4PRO_0000269264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei97 – 971PhosphoserineBy similarity
    Modified residuei252 – 2521Phosphoserine2 Publications
    Modified residuei255 – 2551Phosphoserine2 Publications
    Modified residuei326 – 3261Phosphothreonine1 Publication
    Modified residuei330 – 3301Phosphoserine1 Publication
    Modified residuei332 – 3321Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ17RY0.
    PaxDbiQ17RY0.
    PRIDEiQ17RY0.

    PTM databases

    PhosphoSiteiQ17RY0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ17RY0.
    BgeeiQ17RY0.
    CleanExiHS_CPEB4.
    GenevestigatoriQ17RY0.

    Organism-specific databases

    HPAiHPA038392.
    HPA038394.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TOB1P506162EBI-2848203,EBI-723281

    Protein-protein interaction databases

    BioGridi123228. 4 interactions.
    IntActiQ17RY0. 3 interactions.
    MINTiMINT-4826077.
    STRINGi9606.ENSP00000265085.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17RY0.
    SMRiQ17RY0. Positions 472-571, 655-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini472 – 56392RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini580 – 66283RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi232 – 24615His-richAdd
    BLAST
    Compositional biasi302 – 31110Poly-Gly

    Sequence similaritiesi

    Belongs to the RRM CPEB family.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG240295.
    HOVERGENiHBG058010.
    InParanoidiQ17RY0.
    OMAiTHNSVQD.
    OrthoDBiEOG7X3QR2.
    PhylomeDBiQ17RY0.
    TreeFamiTF317658.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q17RY0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA    50
    ANGSSAGSAW LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP 100
    GQEAGILPET EKAKSEENQG DNSSENGNGK EKIRIESPVL TGFDYQEATG 150
    LGTSTQPLTS SASSLTGFSN WSAAIAPSSS TIINEDASFF HQGGVPAASA 200
    NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ HHHSQHQQQR 250
    RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS 300
    PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR 350
    PSSAFAPKSW MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT 400
    IKGRLNYSYP GSDSSLLINA RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH 450
    SGLGSPHCFS HQNGERVERY SRKVFVGGLP PDIDEDEITA SFRRFGPLIV 500
    DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG KLYLCVSSPT 550
    IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM 600
    DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE 650
    IDKRVEVKPY VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA 700
    IHSRAGREFH KPLVKEGGDR PRHISFRWN 729
    Length:729
    Mass (Da):80,152
    Last modified:July 25, 2006 - v1
    Checksum:iB71AAB0650E8CB13
    GO
    Isoform 2 (identifier: Q17RY0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         403-419: Missing.

    Show »
    Length:712
    Mass (Da):78,314
    Checksum:i6F001427FE1FB724
    GO
    Isoform 3 (identifier: Q17RY0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-382: Missing.
         404-428: Missing.

    Show »
    Length:322
    Mass (Da):36,212
    Checksum:iF366DD034761699C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2281P → L in CAD98072. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 382382Missing in isoform 3. 1 PublicationVSP_022040Add
    BLAST
    Alternative sequencei403 – 41917Missing in isoform 2. 2 PublicationsVSP_022041Add
    BLAST
    Alternative sequencei404 – 42825Missing in isoform 3. 1 PublicationVSP_022042Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051460 mRNA. Translation: BAB21764.1.
    BX538213 mRNA. Translation: CAD98072.1.
    CH471062 Genomic DNA. Translation: EAW61392.1.
    BC036899 mRNA. Translation: AAH36899.1.
    BC117150 mRNA. Translation: AAI17151.1.
    BC143958 mRNA. Translation: AAI43959.1.
    CCDSiCCDS4390.1. [Q17RY0-1]
    RefSeqiNP_085130.2. NM_030627.2. [Q17RY0-1]
    XP_005266052.1. XM_005265995.1. [Q17RY0-2]
    UniGeneiHs.127126.

    Genome annotation databases

    EnsembliENST00000265085; ENSP00000265085; ENSG00000113742. [Q17RY0-1]
    ENST00000334035; ENSP00000334533; ENSG00000113742. [Q17RY0-2]
    ENST00000517880; ENSP00000427990; ENSG00000113742. [Q17RY0-3]
    GeneIDi80315.
    KEGGihsa:80315.
    UCSCiuc003mcs.4. human. [Q17RY0-1]
    uc003mcu.4. human. [Q17RY0-3]
    uc010jjv.3. human. [Q17RY0-2]

    Polymorphism databases

    DMDMi119368635.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051460 mRNA. Translation: BAB21764.1 .
    BX538213 mRNA. Translation: CAD98072.1 .
    CH471062 Genomic DNA. Translation: EAW61392.1 .
    BC036899 mRNA. Translation: AAH36899.1 .
    BC117150 mRNA. Translation: AAI17151.1 .
    BC143958 mRNA. Translation: AAI43959.1 .
    CCDSi CCDS4390.1. [Q17RY0-1 ]
    RefSeqi NP_085130.2. NM_030627.2. [Q17RY0-1 ]
    XP_005266052.1. XM_005265995.1. [Q17RY0-2 ]
    UniGenei Hs.127126.

    3D structure databases

    ProteinModelPortali Q17RY0.
    SMRi Q17RY0. Positions 472-571, 655-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123228. 4 interactions.
    IntActi Q17RY0. 3 interactions.
    MINTi MINT-4826077.
    STRINGi 9606.ENSP00000265085.

    PTM databases

    PhosphoSitei Q17RY0.

    Polymorphism databases

    DMDMi 119368635.

    Proteomic databases

    MaxQBi Q17RY0.
    PaxDbi Q17RY0.
    PRIDEi Q17RY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265085 ; ENSP00000265085 ; ENSG00000113742 . [Q17RY0-1 ]
    ENST00000334035 ; ENSP00000334533 ; ENSG00000113742 . [Q17RY0-2 ]
    ENST00000517880 ; ENSP00000427990 ; ENSG00000113742 . [Q17RY0-3 ]
    GeneIDi 80315.
    KEGGi hsa:80315.
    UCSCi uc003mcs.4. human. [Q17RY0-1 ]
    uc003mcu.4. human. [Q17RY0-3 ]
    uc010jjv.3. human. [Q17RY0-2 ]

    Organism-specific databases

    CTDi 80315.
    GeneCardsi GC05P173315.
    HGNCi HGNC:21747. CPEB4.
    HPAi HPA038392.
    HPA038394.
    MIMi 610607. gene.
    neXtProti NX_Q17RY0.
    PharmGKBi PA134869176.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240295.
    HOVERGENi HBG058010.
    InParanoidi Q17RY0.
    OMAi THNSVQD.
    OrthoDBi EOG7X3QR2.
    PhylomeDBi Q17RY0.
    TreeFami TF317658.

    Miscellaneous databases

    ChiTaRSi CPEB4. human.
    GenomeRNAii 80315.
    NextBioi 70816.
    PROi Q17RY0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q17RY0.
    Bgeei Q17RY0.
    CleanExi HS_CPEB4.
    Genevestigatori Q17RY0.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain and Lymphoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255 AND THR-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252; SER-255; SER-330 AND SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCPEB4_HUMAN
    AccessioniPrimary (citable) accession number: Q17RY0
    Secondary accession number(s): B7ZLQ7
    , Q7Z310, Q8N405, Q9C0J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3