Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pancreatic lipase-related protein 3

Gene

PNLIPRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168NucleophileBy similarity1
Active sitei191Charge relay systemPROSITE-ProRule annotation1
Active sitei279Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciZFISH:G66-30919-MONOMER.
ReactomeiR-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-PNLIPRP3. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic lipase-related protein 3 (EC:3.1.1.3)
Short name:
PL-RP3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23492. PNLIPRP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203837.
PharmGKBiPA134954941.

Polymorphism and mutation databases

BioMutaiPNLIPRP3.
DMDMi269849614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028660218 – 467Pancreatic lipase-related protein 3Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27By similarity
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 118By similarity
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi252 ↔ 277By similarity
Disulfide bondi301 ↔ 312By similarity
Disulfide bondi315 ↔ 320By similarity
Disulfide bondi451 ↔ 467By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ17RR3.
PaxDbiQ17RR3.
PeptideAtlasiQ17RR3.
PRIDEiQ17RR3.

PTM databases

iPTMnetiQ17RR3.
PhosphoSitePlusiQ17RR3.

Expressioni

Tissue specificityi

Overexpressed in hepatocellular carcinoma.1 Publication

Gene expression databases

BgeeiENSG00000203837.
CleanExiHS_PNLIPRP3.
GenevisibleiQ17RR3. HS.

Organism-specific databases

HPAiHPA046202.
HPA052009.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358232.

Structurei

3D structure databases

ProteinModelPortaliQ17RR3.
SMRiQ17RR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 467PLATAdd BLAST113

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4Z. Eukaryota.
ENOG41118P1. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiQ17RR3.
KOiK14076.
OMAiYKSTFCS.
OrthoDBiEOG091G0DJ5.
PhylomeDBiQ17RR3.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17RR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIWIVAFL FFGTSRGKEV CYERLGCFKD GLPWTRTFST ELVGLPWSPE
60 70 80 90 100
KINTRFLLYT IHNPNAYQEI SAVNSSTIQA SYFGTDKITR INIAGWKTDG
110 120 130 140 150
KWQRDMCNVL LQLEDINCIN LDWINGSREY IHAVNNLRVV GAEVAYFIDV
160 170 180 190 200
LMKKFEYSPS KVHLIGHSLG AHLAGEAGSR IPGLGRITGL DPAGPFFHNT
210 220 230 240 250
PKEVRLDPSD ANFVDVIHTN AARILFELGV GTIDACGHLD FYPNGGKHMP
260 270 280 290 300
GCEDLITPLL KFNFNAYKKE MASFFDCNHA RSYQFYAESI LNPDAFIAYP
310 320 330 340 350
CRSYTSFKAG NCFFCSKEGC PTMGHFADRF HFKNMKTNGS HYFLNTGSLS
360 370 380 390 400
PFARWRHKLS VKLSGSEVTQ GTVFLRVGGA VRKTGEFAIV SGKLEPGMTY
410 420 430 440 450
TKLIDADVNV GNITSVQFIW KKHLFEDSQN KLGAEMVINT SGKYGYKSTF
460
CSQDIMGPNI LQNLKPC
Length:467
Mass (Da):52,254
Last modified:November 24, 2009 - v2
Checksum:iF383E516278D1FC2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0321412L → F.Corresponds to variant rs10885929dbSNPEnsembl.1
Natural variantiVAR_032142332F → L.Corresponds to variant rs7077408dbSNPEnsembl.1
Natural variantiVAR_060285381V → I.1 PublicationCorresponds to variant rs10736251dbSNPEnsembl.1
Natural variantiVAR_060286382R → G.1 PublicationCorresponds to variant rs1897519dbSNPEnsembl.1
Natural variantiVAR_032143450F → Y.Corresponds to variant rs2116286dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA. No translation available.
BC117224 mRNA. Translation: AAI17225.1.
CCDSiCCDS31292.1.
RefSeqiNP_001011709.2. NM_001011709.2.
UniGeneiHs.276724.

Genome annotation databases

EnsembliENST00000369230; ENSP00000358232; ENSG00000203837.
GeneIDi119548.
KEGGihsa:119548.
UCSCiuc001lcl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA. No translation available.
BC117224 mRNA. Translation: AAI17225.1.
CCDSiCCDS31292.1.
RefSeqiNP_001011709.2. NM_001011709.2.
UniGeneiHs.276724.

3D structure databases

ProteinModelPortaliQ17RR3.
SMRiQ17RR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358232.

Protein family/group databases

ESTHERihuman-PNLIPRP3. Pancreatic_lipase.

PTM databases

iPTMnetiQ17RR3.
PhosphoSitePlusiQ17RR3.

Polymorphism and mutation databases

BioMutaiPNLIPRP3.
DMDMi269849614.

Proteomic databases

EPDiQ17RR3.
PaxDbiQ17RR3.
PeptideAtlasiQ17RR3.
PRIDEiQ17RR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369230; ENSP00000358232; ENSG00000203837.
GeneIDi119548.
KEGGihsa:119548.
UCSCiuc001lcl.5. human.

Organism-specific databases

CTDi119548.
GeneCardsiPNLIPRP3.
H-InvDBHIX0009234.
HGNCiHGNC:23492. PNLIPRP3.
HPAiHPA046202.
HPA052009.
neXtProtiNX_Q17RR3.
OpenTargetsiENSG00000203837.
PharmGKBiPA134954941.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK4Z. Eukaryota.
ENOG41118P1. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiQ17RR3.
KOiK14076.
OMAiYKSTFCS.
OrthoDBiEOG091G0DJ5.
PhylomeDBiQ17RR3.
TreeFamiTF324997.

Enzyme and pathway databases

BioCyciZFISH:G66-30919-MONOMER.
ReactomeiR-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

ChiTaRSiPNLIPRP3. human.
GenomeRNAii119548.
PROiQ17RR3.

Gene expression databases

BgeeiENSG00000203837.
CleanExiHS_PNLIPRP3.
GenevisibleiQ17RR3. HS.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPR3_HUMAN
AccessioniPrimary (citable) accession number: Q17RR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.