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Protein

Pancreatic lipase-related protein 3

Gene

PNLIPRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681NucleophileBy similarity
Active sitei191 – 1911Charge relay systemPROSITE-ProRule annotation
Active sitei279 – 2791Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-PNLIPRP3. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic lipase-related protein 3 (EC:3.1.1.3)
Short name:
PL-RP3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23492. PNLIPRP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954941.

Polymorphism and mutation databases

BioMutaiPNLIPRP3.
DMDMi269849614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 467450Pancreatic lipase-related protein 3PRO_0000286602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 27By similarity
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi107 ↔ 118By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi252 ↔ 277By similarity
Disulfide bondi301 ↔ 312By similarity
Disulfide bondi315 ↔ 320By similarity
Disulfide bondi451 ↔ 467By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ17RR3.
PaxDbiQ17RR3.
PRIDEiQ17RR3.

PTM databases

PhosphoSiteiQ17RR3.

Expressioni

Tissue specificityi

Overexpressed in hepatocellular carcinoma.1 Publication

Gene expression databases

BgeeiQ17RR3.
CleanExiHS_PNLIPRP3.
GenevisibleiQ17RR3. HS.

Organism-specific databases

HPAiHPA046202.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358232.

Structurei

3D structure databases

ProteinModelPortaliQ17RR3.
SMRiQ17RR3. Positions 45-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini355 – 467113PLATAdd
BLAST

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4Z. Eukaryota.
ENOG41118P1. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiQ17RR3.
KOiK14076.
OMAiYKSTFCS.
OrthoDBiEOG7KSX8B.
PhylomeDBiQ17RR3.
TreeFamiTF324997.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17RR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIWIVAFL FFGTSRGKEV CYERLGCFKD GLPWTRTFST ELVGLPWSPE
60 70 80 90 100
KINTRFLLYT IHNPNAYQEI SAVNSSTIQA SYFGTDKITR INIAGWKTDG
110 120 130 140 150
KWQRDMCNVL LQLEDINCIN LDWINGSREY IHAVNNLRVV GAEVAYFIDV
160 170 180 190 200
LMKKFEYSPS KVHLIGHSLG AHLAGEAGSR IPGLGRITGL DPAGPFFHNT
210 220 230 240 250
PKEVRLDPSD ANFVDVIHTN AARILFELGV GTIDACGHLD FYPNGGKHMP
260 270 280 290 300
GCEDLITPLL KFNFNAYKKE MASFFDCNHA RSYQFYAESI LNPDAFIAYP
310 320 330 340 350
CRSYTSFKAG NCFFCSKEGC PTMGHFADRF HFKNMKTNGS HYFLNTGSLS
360 370 380 390 400
PFARWRHKLS VKLSGSEVTQ GTVFLRVGGA VRKTGEFAIV SGKLEPGMTY
410 420 430 440 450
TKLIDADVNV GNITSVQFIW KKHLFEDSQN KLGAEMVINT SGKYGYKSTF
460
CSQDIMGPNI LQNLKPC
Length:467
Mass (Da):52,254
Last modified:November 24, 2009 - v2
Checksum:iF383E516278D1FC2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21L → F.
Corresponds to variant rs10885929 [ dbSNP | Ensembl ].
VAR_032141
Natural varianti332 – 3321F → L.
Corresponds to variant rs7077408 [ dbSNP | Ensembl ].
VAR_032142
Natural varianti381 – 3811V → I.1 Publication
Corresponds to variant rs10736251 [ dbSNP | Ensembl ].
VAR_060285
Natural varianti382 – 3821R → G.1 Publication
Corresponds to variant rs1897519 [ dbSNP | Ensembl ].
VAR_060286
Natural varianti450 – 4501F → Y.
Corresponds to variant rs2116286 [ dbSNP | Ensembl ].
VAR_032143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA. No translation available.
BC117224 mRNA. Translation: AAI17225.1.
CCDSiCCDS31292.1.
RefSeqiNP_001011709.2. NM_001011709.2.
UniGeneiHs.276724.

Genome annotation databases

EnsembliENST00000369230; ENSP00000358232; ENSG00000203837.
GeneIDi119548.
KEGGihsa:119548.
UCSCiuc001lcl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA. No translation available.
BC117224 mRNA. Translation: AAI17225.1.
CCDSiCCDS31292.1.
RefSeqiNP_001011709.2. NM_001011709.2.
UniGeneiHs.276724.

3D structure databases

ProteinModelPortaliQ17RR3.
SMRiQ17RR3. Positions 45-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358232.

Protein family/group databases

ESTHERihuman-PNLIPRP3. Pancreatic_lipase.

PTM databases

PhosphoSiteiQ17RR3.

Polymorphism and mutation databases

BioMutaiPNLIPRP3.
DMDMi269849614.

Proteomic databases

EPDiQ17RR3.
PaxDbiQ17RR3.
PRIDEiQ17RR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369230; ENSP00000358232; ENSG00000203837.
GeneIDi119548.
KEGGihsa:119548.
UCSCiuc001lcl.5. human.

Organism-specific databases

CTDi119548.
GeneCardsiPNLIPRP3.
H-InvDBHIX0009234.
HGNCiHGNC:23492. PNLIPRP3.
HPAiHPA046202.
neXtProtiNX_Q17RR3.
PharmGKBiPA134954941.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK4Z. Eukaryota.
ENOG41118P1. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiQ17RR3.
KOiK14076.
OMAiYKSTFCS.
OrthoDBiEOG7KSX8B.
PhylomeDBiQ17RR3.
TreeFamiTF324997.

Enzyme and pathway databases

ReactomeiR-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

ChiTaRSiPNLIPRP3. human.
GenomeRNAii119548.
NextBioi80433.
PROiQ17RR3.

Gene expression databases

BgeeiQ17RR3.
CleanExiHS_PNLIPRP3.
GenevisibleiQ17RR3. HS.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-381 AND GLY-382.
  3. "Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma."
    Saelee P., Wongkham S., Puapairoj A., Khuntikeo N., Petmitr S., Chariyalertsak S., Sumethchotimaytha W., Karalak A.
    Asian Pac. J. Cancer Prev. 10:501-506(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLIPR3_HUMAN
AccessioniPrimary (citable) accession number: Q17RR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 24, 2009
Last modified: March 16, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.