Unreviewed, UniProtKB/TrEMBL Q17RQ6 (Q17RQ6_HUMAN)

Names and origin

Protein names

Submitted name:
    Phospholipase C, beta 1 (Phosphoinositide-specific) EMBL AAI17232.1
Submitted name:
    Phospholipase C, beta 1 (Phosphoinositide-specific), isoform CRA_b EMBL EAX10374.1

Gene names

Name:	PLCB1 EMBL AAI17232.1
ORF Names:	hCG_1811059 EMBL EAX10374.1

Organism

Homo sapiens (Human) EMBL AAI17232.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412V0 Spearmint SPM001192 Contains 1 PI-PLC X-box domain. Spearmint SPM001192 Contains 1 PI-PLC Y-box domain. Spearmint SPM001192

Ontologies

Keywords
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q17RQ6-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: B9DA88251A5769FB	FASTA	1,173	133,703
	10 20 30 40 50 60 MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF FFYWTDQNKE 70 80 90 100 110 120 TELLDLSLVK DARCGRHAKA PKDPKLRELL DVGNIGRLEQ RMITVVYGPD LVNISHLNLV 130 140 150 160 170 180 AFQEEVAKEW TNEVFSLATN LLAQNMSRDA FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA 190 200 210 220 230 240 DRKRVETALE ACSLPSSRND SIPQEDFTPE VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL 250 260 270 280 290 300 TVDQMMDFIN LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NNSLARKGQI SVDGFMRYLS 310 320 330 340 350 360 GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR QVLLSGCRCV 370 380 390 400 410 420 ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF KTSPFPILLS FENHVDSPKQ 430 440 450 460 470 480 QAKMAEYCRL IFGDALLMEP LEKYPLESGV PLPSPMDLMY KILVKNKKKS HKSSEGSGKK 490 500 510 520 530 540 KLSEQASNTY SDSSSMFEPS SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM 550 560 570 580 590 600 SNLVNYIQPV KFESFEISKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK 610 620 630 640 650 660 GTRVDSSNYM PQLFWNAGCQ MVALNFQTMD LAMQINMGMY EYNGKSGYRL KPEFMRRPDK 670 680 690 700 710 720 HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD MFGLPVDTRR KAFKTKTSQG 730 740 750 760 770 780 NAVNPVWEEE PIVFKKVVLP TLACLRIAVY EEGGKFIGHR ILPVQAIRPG YHYICLRNER 790 800 810 820 830 840 NQPLTLPAVF VYIEVKDYVP DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK 850 860 870 880 890 900 EADPGETPSE APSEARTTPA ENGVNHTTTL TPKPPSQALH SQPAPGSVKA PAKTEDLIQS 910 920 930 940 950 960 VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTDLIKEHTT KYNEIQNDYL 970 980 990 1000 1010 1020 RRRAALEKSA KKDSKKKSEP SSPDHGSSTI EQDLAALDAE MTQKLIDLKD KQQQQLLNLR 1030 1040 1050 1060 1070 1080 QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ NNQLKKLKEI CEKEKKELKK KMDKKRQEKI 1090 1100 1110 1120 1130 1140 TEAKSKDKSQ MEEEKTEMIR SYIQEVVQYI KRLEEAQSKR QEKLVEKHKE IRQQILDEKP 1150 1160 1170 KGEGSSSFLS ETCHEDPSVS PNFTPPNPQA LKW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI17232.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC117231 mRNA. Translation: AAI17232.1. CH471133 Genomic DNA. Translation: EAX10374.1.
RefSeq	NP_877398.1.
UniGene	Hs.431173
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000182621. Homo sapiens. [Contig view]
GeneID	23236.
Organism-specific databases
HGNC	HGNC:15917. PLCB1.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q17RQ6.
Gene expression databases
ArrayExpress	Q17RQ6.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR011992. EF-Hand_type. IPR015359. Phospholipase_C_EF-hand-like. IPR013841. Phospholipase_C_PI-sp_X/Y. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR000909. Phospholipase_C_Pinositol-sp_X. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016280. PLC-beta. IPR014815. PLC-beta_C. IPR017946. PLC-like_Pdiesterase_TIM-brl. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. PF08703. PLC-beta_C. 1 hit. [Graphical view]
PIRSF	PIRSF000956. PLC-beta. 1 hit.
PRINTS	PR00390. PHPHLIPASEC.
ProDom	PD001202. PI_PLC_Y. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
Other Resources
NextBio	44882.

Entry information

Entry name

Q17RQ6_HUMAN

Accession

Primary (citable) accession number: Q17RQ6

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)