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Q17RP2

- TIGD6_HUMAN

UniProt

Q17RP2 - TIGD6_HUMAN

Protein

Tigger transposable element-derived protein 6

Gene

TIGD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi30 – 5021H-T-H motifBy similarityAdd
    BLAST
    DNA bindingi99 – 13032H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tigger transposable element-derived protein 6
    Gene namesi
    Name:TIGD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:18332. TIGD6.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38525.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Tigger transposable element-derived protein 6PRO_0000272619Add
    BLAST

    Proteomic databases

    PaxDbiQ17RP2.
    PRIDEiQ17RP2.

    PTM databases

    PhosphoSiteiQ17RP2.

    Expressioni

    Gene expression databases

    BgeeiQ17RP2.
    CleanExiHS_TIGD6.
    GenevestigatoriQ17RP2.

    Organism-specific databases

    HPAiHPA044599.

    Interactioni

    Protein-protein interaction databases

    BioGridi123582. 1 interaction.
    MINTiMINT-4718610.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17RP2.
    SMRiQ17RP2. Positions 8-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 5452HTH psq-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini66 – 13772HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini170 – 372203DDEAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG265486.
    HOGENOMiHOG000136548.
    HOVERGENiHBG095356.
    InParanoidiQ17RP2.
    OMAiKAVCRED.
    OrthoDBiEOG71G9TH.
    PhylomeDBiQ17RP2.
    TreeFamiTF101131.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view]
    PfamiPF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17RP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD    50
    RTKFEEKVRE ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV 100
    IRKKALNLAN MLGYDNFQAS VGWLNRFRDR HGIALKAVCR EDSDRLMNGL 150
    GIDKINEWHA GEIIKLIADY SPDDIFNADE TGVFFQLLPQ HTLAAKGDHC 200
    RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN IHSLPCDYRA 250
    NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV 300
    GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK 350
    QAIDMIAAAW WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK 400
    LWHTVAIATC VPNEVNFQDF VTADDDLIIS QDTDIIQDMV AGENTSEAGS 450
    EDEGEVSLPE QPKVTITEAI SSVQKLRQFL STCVDIPDAI FGQLNGIDEY 500
    LMKRVTQTLI DSKITDFLQT K 521
    Length:521
    Mass (Da):58,656
    Last modified:January 23, 2007 - v2
    Checksum:i2C0526E08036324A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61N → K in BAB71230. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591R → W.
    Corresponds to variant rs9324636 [ dbSNP | Ensembl ].
    VAR_030044
    Natural varianti327 – 3271Q → R.1 Publication
    Corresponds to variant rs10875553 [ dbSNP | Ensembl ].
    VAR_030045

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136539 mRNA. Translation: CAB66474.1.
    AK056604 mRNA. Translation: BAB71230.1.
    AK096325 mRNA. Translation: BAG53260.1.
    CR533559 mRNA. Translation: CAG38590.1.
    BC117249 mRNA. Translation: AAI17250.1.
    CCDSiCCDS4301.1.
    RefSeqiNP_001230182.1. NM_001243253.1.
    NP_112215.1. NM_030953.3.
    UniGeneiHs.169333.

    Genome annotation databases

    EnsembliENST00000296736; ENSP00000296736; ENSG00000164296.
    ENST00000515406; ENSP00000425318; ENSG00000164296.
    GeneIDi81789.
    KEGGihsa:81789.
    UCSCiuc003lri.3. human.

    Polymorphism databases

    DMDMi124053415.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136539 mRNA. Translation: CAB66474.1 .
    AK056604 mRNA. Translation: BAB71230.1 .
    AK096325 mRNA. Translation: BAG53260.1 .
    CR533559 mRNA. Translation: CAG38590.1 .
    BC117249 mRNA. Translation: AAI17250.1 .
    CCDSi CCDS4301.1.
    RefSeqi NP_001230182.1. NM_001243253.1.
    NP_112215.1. NM_030953.3.
    UniGenei Hs.169333.

    3D structure databases

    ProteinModelPortali Q17RP2.
    SMRi Q17RP2. Positions 8-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123582. 1 interaction.
    MINTi MINT-4718610.

    PTM databases

    PhosphoSitei Q17RP2.

    Polymorphism databases

    DMDMi 124053415.

    Proteomic databases

    PaxDbi Q17RP2.
    PRIDEi Q17RP2.

    Protocols and materials databases

    DNASUi 81789.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296736 ; ENSP00000296736 ; ENSG00000164296 .
    ENST00000515406 ; ENSP00000425318 ; ENSG00000164296 .
    GeneIDi 81789.
    KEGGi hsa:81789.
    UCSCi uc003lri.3. human.

    Organism-specific databases

    CTDi 81789.
    GeneCardsi GC05M149372.
    HGNCi HGNC:18332. TIGD6.
    HPAi HPA044599.
    neXtProti NX_Q17RP2.
    PharmGKBi PA38525.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265486.
    HOGENOMi HOG000136548.
    HOVERGENi HBG095356.
    InParanoidi Q17RP2.
    OMAi KAVCRED.
    OrthoDBi EOG71G9TH.
    PhylomeDBi Q17RP2.
    TreeFami TF101131.

    Miscellaneous databases

    GenomeRNAii 81789.
    NextBioi 72092.
    PROi Q17RP2.

    Gene expression databases

    Bgeei Q17RP2.
    CleanExi HS_TIGD6.
    Genevestigatori Q17RP2.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view ]
    Pfami PF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-327.
      Tissue: Colon.

    Entry informationi

    Entry nameiTIGD6_HUMAN
    AccessioniPrimary (citable) accession number: Q17RP2
    Secondary accession number(s): B3KTZ8, Q96MQ4, Q9H0X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3