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Q17RP2

- TIGD6_HUMAN

UniProt

Q17RP2 - TIGD6_HUMAN

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Protein

Tigger transposable element-derived protein 6

Gene

TIGD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi30 – 5021H-T-H motifBy similarityAdd
BLAST
DNA bindingi99 – 13032H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 6
Gene namesi
Name:TIGD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:18332. TIGD6.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Tigger transposable element-derived protein 6PRO_0000272619Add
BLAST

Proteomic databases

PaxDbiQ17RP2.
PRIDEiQ17RP2.

PTM databases

PhosphoSiteiQ17RP2.

Expressioni

Gene expression databases

BgeeiQ17RP2.
CleanExiHS_TIGD6.
GenevestigatoriQ17RP2.

Organism-specific databases

HPAiHPA044599.

Interactioni

Protein-protein interaction databases

BioGridi123582. 1 interaction.
MINTiMINT-4718610.

Structurei

3D structure databases

ProteinModelPortaliQ17RP2.
SMRiQ17RP2. Positions 8-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5452HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini66 – 13772HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini170 – 372203DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG265486.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000136548.
HOVERGENiHBG095356.
InParanoidiQ17RP2.
OMAiKAVCRED.
OrthoDBiEOG71G9TH.
PhylomeDBiQ17RP2.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17RP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD
60 70 80 90 100
RTKFEEKVRE ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV
110 120 130 140 150
IRKKALNLAN MLGYDNFQAS VGWLNRFRDR HGIALKAVCR EDSDRLMNGL
160 170 180 190 200
GIDKINEWHA GEIIKLIADY SPDDIFNADE TGVFFQLLPQ HTLAAKGDHC
210 220 230 240 250
RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN IHSLPCDYRA
260 270 280 290 300
NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV
310 320 330 340 350
GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK
360 370 380 390 400
QAIDMIAAAW WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK
410 420 430 440 450
LWHTVAIATC VPNEVNFQDF VTADDDLIIS QDTDIIQDMV AGENTSEAGS
460 470 480 490 500
EDEGEVSLPE QPKVTITEAI SSVQKLRQFL STCVDIPDAI FGQLNGIDEY
510 520
LMKRVTQTLI DSKITDFLQT K
Length:521
Mass (Da):58,656
Last modified:January 23, 2007 - v2
Checksum:i2C0526E08036324A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61N → K in BAB71230. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591R → W.
Corresponds to variant rs9324636 [ dbSNP | Ensembl ].
VAR_030044
Natural varianti327 – 3271Q → R.1 Publication
Corresponds to variant rs10875553 [ dbSNP | Ensembl ].
VAR_030045

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136539 mRNA. Translation: CAB66474.1.
AK056604 mRNA. Translation: BAB71230.1.
AK096325 mRNA. Translation: BAG53260.1.
CR533559 mRNA. Translation: CAG38590.1.
BC117249 mRNA. Translation: AAI17250.1.
CCDSiCCDS4301.1.
RefSeqiNP_001230182.1. NM_001243253.1.
NP_112215.1. NM_030953.3.
UniGeneiHs.169333.

Genome annotation databases

EnsembliENST00000296736; ENSP00000296736; ENSG00000164296.
ENST00000515406; ENSP00000425318; ENSG00000164296.
GeneIDi81789.
KEGGihsa:81789.
UCSCiuc003lri.3. human.

Polymorphism databases

DMDMi124053415.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136539 mRNA. Translation: CAB66474.1 .
AK056604 mRNA. Translation: BAB71230.1 .
AK096325 mRNA. Translation: BAG53260.1 .
CR533559 mRNA. Translation: CAG38590.1 .
BC117249 mRNA. Translation: AAI17250.1 .
CCDSi CCDS4301.1.
RefSeqi NP_001230182.1. NM_001243253.1.
NP_112215.1. NM_030953.3.
UniGenei Hs.169333.

3D structure databases

ProteinModelPortali Q17RP2.
SMRi Q17RP2. Positions 8-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123582. 1 interaction.
MINTi MINT-4718610.

PTM databases

PhosphoSitei Q17RP2.

Polymorphism databases

DMDMi 124053415.

Proteomic databases

PaxDbi Q17RP2.
PRIDEi Q17RP2.

Protocols and materials databases

DNASUi 81789.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296736 ; ENSP00000296736 ; ENSG00000164296 .
ENST00000515406 ; ENSP00000425318 ; ENSG00000164296 .
GeneIDi 81789.
KEGGi hsa:81789.
UCSCi uc003lri.3. human.

Organism-specific databases

CTDi 81789.
GeneCardsi GC05M149372.
HGNCi HGNC:18332. TIGD6.
HPAi HPA044599.
neXtProti NX_Q17RP2.
PharmGKBi PA38525.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265486.
GeneTreei ENSGT00760000119149.
HOGENOMi HOG000136548.
HOVERGENi HBG095356.
InParanoidi Q17RP2.
OMAi KAVCRED.
OrthoDBi EOG71G9TH.
PhylomeDBi Q17RP2.
TreeFami TF101131.

Miscellaneous databases

GenomeRNAii 81789.
NextBioi 72092.
PROi Q17RP2.

Gene expression databases

Bgeei Q17RP2.
CleanExi HS_TIGD6.
Genevestigatori Q17RP2.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view ]
Pfami PF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-327.
    Tissue: Colon.

Entry informationi

Entry nameiTIGD6_HUMAN
AccessioniPrimary (citable) accession number: Q17RP2
Secondary accession number(s): B3KTZ8, Q96MQ4, Q9H0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3