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Q17RP2 (TIGD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tigger transposable element-derived protein 6
Gene names
Name:TIGD6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the tigger transposable element derived protein family.

Contains 1 DDE domain.

Contains 1 HTH CENPB-type DNA-binding domain.

Contains 1 HTH psq-type DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay. Source: LIFEdb

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Tigger transposable element-derived protein 6
PRO_0000272619

Regions

Domain3 – 5452HTH psq-type
Domain66 – 13772HTH CENPB-type
Domain170 – 372203DDE
DNA binding30 – 5021H-T-H motif By similarity
DNA binding99 – 13032H-T-H motif By similarity

Natural variations

Natural variant591R → W.
Corresponds to variant rs9324636 [ dbSNP | Ensembl ].
VAR_030044
Natural variant3271Q → R. Ref.4
Corresponds to variant rs10875553 [ dbSNP | Ensembl ].
VAR_030045

Experimental info

Sequence conflict61N → K in BAB71230. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q17RP2 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2C0526E08036324A

FASTA52158,656
        10         20         30         40         50         60 
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE 

        70         80         90        100        110        120 
ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS 

       130        140        150        160        170        180 
VGWLNRFRDR HGIALKAVCR EDSDRLMNGL GIDKINEWHA GEIIKLIADY SPDDIFNADE 

       190        200        210        220        230        240 
TGVFFQLLPQ HTLAAKGDHC RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN 

       250        260        270        280        290        300 
IHSLPCDYRA NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV 

       310        320        330        340        350        360 
GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK QAIDMIAAAW 

       370        380        390        400        410        420 
WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK LWHTVAIATC VPNEVNFQDF 

       430        440        450        460        470        480 
VTADDDLIIS QDTDIIQDMV AGENTSEAGS EDEGEVSLPE QPKVTITEAI SSVQKLRQFL 

       490        500        510        520 
STCVDIPDAI FGQLNGIDEY LMKRVTQTLI DSKITDFLQT K 

« Hide

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-327.
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136539 mRNA. Translation: CAB66474.1.
AK056604 mRNA. Translation: BAB71230.1.
AK096325 mRNA. Translation: BAG53260.1.
CR533559 mRNA. Translation: CAG38590.1.
BC117249 mRNA. Translation: AAI17250.1.
RefSeqNP_001230182.1. NM_001243253.1.
NP_112215.1. NM_030953.3.
UniGeneHs.169333.

3D structure databases

ProteinModelPortalQ17RP2.
SMRQ17RP2. Positions 8-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123582. 1 interaction.
MINTMINT-4718610.

PTM databases

PhosphoSiteQ17RP2.

Polymorphism databases

DMDM124053415.

Proteomic databases

PaxDbQ17RP2.
PRIDEQ17RP2.

Protocols and materials databases

DNASU81789.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296736; ENSP00000296736; ENSG00000164296.
ENST00000515406; ENSP00000425318; ENSG00000164296.
GeneID81789.
KEGGhsa:81789.
UCSCuc003lri.3. human.

Organism-specific databases

CTD81789.
GeneCardsGC05M149372.
HGNCHGNC:18332. TIGD6.
HPAHPA044599.
neXtProtNX_Q17RP2.
PharmGKBPA38525.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG265486.
HOGENOMHOG000136548.
HOVERGENHBG095356.
InParanoidQ17RP2.
OMAKAVCRED.
OrthoDBEOG71G9TH.
PhylomeDBQ17RP2.
TreeFamTF101131.

Gene expression databases

BgeeQ17RP2.
CleanExHS_TIGD6.
GenevestigatorQ17RP2.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi81789.
NextBio72092.
PROQ17RP2.

Entry information

Entry nameTIGD6_HUMAN
AccessionPrimary (citable) accession number: Q17RP2
Secondary accession number(s): B3KTZ8, Q96MQ4, Q9H0X7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM