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Protein

Tigger transposable element-derived protein 6

Gene

TIGD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 50H-T-H motifBy similarityAdd BLAST21
DNA bindingi99 – 130H-T-H motifBy similarityAdd BLAST32

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 6
Gene namesi
Name:TIGD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18332. TIGD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164296.
PharmGKBiPA38525.

Polymorphism and mutation databases

BioMutaiTIGD6.
DMDMi124053415.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002726191 – 521Tigger transposable element-derived protein 6Add BLAST521

Proteomic databases

PaxDbiQ17RP2.
PRIDEiQ17RP2.

PTM databases

iPTMnetiQ17RP2.
PhosphoSitePlusiQ17RP2.

Expressioni

Gene expression databases

BgeeiENSG00000164296.
CleanExiHS_TIGD6.
GenevisibleiQ17RP2. HS.

Organism-specific databases

HPAiHPA044599.

Interactioni

Protein-protein interaction databases

BioGridi123582. 20 interactors.
IntActiQ17RP2. 17 interactors.
MINTiMINT-4718610.
STRINGi9606.ENSP00000296736.

Structurei

3D structure databases

ProteinModelPortaliQ17RP2.
SMRiQ17RP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 54HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini66 – 137HTH CENPB-typePROSITE-ProRule annotationAdd BLAST72
Domaini170 – 372DDE-1Sequence analysisAdd BLAST203

Sequence similaritiesi

Contains 1 DDE-1 domain.Sequence analysis
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000136548.
HOVERGENiHBG095356.
InParanoidiQ17RP2.
OMAiKAVCRED.
OrthoDBiEOG091G0G48.
PhylomeDBiQ17RP2.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17RP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD
60 70 80 90 100
RTKFEEKVRE ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV
110 120 130 140 150
IRKKALNLAN MLGYDNFQAS VGWLNRFRDR HGIALKAVCR EDSDRLMNGL
160 170 180 190 200
GIDKINEWHA GEIIKLIADY SPDDIFNADE TGVFFQLLPQ HTLAAKGDHC
210 220 230 240 250
RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN IHSLPCDYRA
260 270 280 290 300
NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV
310 320 330 340 350
GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK
360 370 380 390 400
QAIDMIAAAW WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK
410 420 430 440 450
LWHTVAIATC VPNEVNFQDF VTADDDLIIS QDTDIIQDMV AGENTSEAGS
460 470 480 490 500
EDEGEVSLPE QPKVTITEAI SSVQKLRQFL STCVDIPDAI FGQLNGIDEY
510 520
LMKRVTQTLI DSKITDFLQT K
Length:521
Mass (Da):58,656
Last modified:January 23, 2007 - v2
Checksum:i2C0526E08036324A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6N → K in BAB71230 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03004459R → W.Corresponds to variant rs9324636dbSNPEnsembl.1
Natural variantiVAR_030045327Q → R.1 PublicationCorresponds to variant rs10875553dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136539 mRNA. Translation: CAB66474.1.
AK056604 mRNA. Translation: BAB71230.1.
AK096325 mRNA. Translation: BAG53260.1.
CR533559 mRNA. Translation: CAG38590.1.
BC117249 mRNA. Translation: AAI17250.1.
CCDSiCCDS4301.1.
RefSeqiNP_001230182.1. NM_001243253.1.
NP_112215.1. NM_030953.3.
UniGeneiHs.169333.

Genome annotation databases

EnsembliENST00000296736; ENSP00000296736; ENSG00000164296.
ENST00000515406; ENSP00000425318; ENSG00000164296.
GeneIDi81789.
KEGGihsa:81789.
UCSCiuc003lri.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136539 mRNA. Translation: CAB66474.1.
AK056604 mRNA. Translation: BAB71230.1.
AK096325 mRNA. Translation: BAG53260.1.
CR533559 mRNA. Translation: CAG38590.1.
BC117249 mRNA. Translation: AAI17250.1.
CCDSiCCDS4301.1.
RefSeqiNP_001230182.1. NM_001243253.1.
NP_112215.1. NM_030953.3.
UniGeneiHs.169333.

3D structure databases

ProteinModelPortaliQ17RP2.
SMRiQ17RP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123582. 20 interactors.
IntActiQ17RP2. 17 interactors.
MINTiMINT-4718610.
STRINGi9606.ENSP00000296736.

PTM databases

iPTMnetiQ17RP2.
PhosphoSitePlusiQ17RP2.

Polymorphism and mutation databases

BioMutaiTIGD6.
DMDMi124053415.

Proteomic databases

PaxDbiQ17RP2.
PRIDEiQ17RP2.

Protocols and materials databases

DNASUi81789.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296736; ENSP00000296736; ENSG00000164296.
ENST00000515406; ENSP00000425318; ENSG00000164296.
GeneIDi81789.
KEGGihsa:81789.
UCSCiuc003lri.4. human.

Organism-specific databases

CTDi81789.
GeneCardsiTIGD6.
HGNCiHGNC:18332. TIGD6.
HPAiHPA044599.
neXtProtiNX_Q17RP2.
OpenTargetsiENSG00000164296.
PharmGKBiPA38525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000136548.
HOVERGENiHBG095356.
InParanoidiQ17RP2.
OMAiKAVCRED.
OrthoDBiEOG091G0G48.
PhylomeDBiQ17RP2.
TreeFamiTF101131.

Miscellaneous databases

GenomeRNAii81789.
PROiQ17RP2.

Gene expression databases

BgeeiENSG00000164296.
CleanExiHS_TIGD6.
GenevisibleiQ17RP2. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIGD6_HUMAN
AccessioniPrimary (citable) accession number: Q17RP2
Secondary accession number(s): B3KTZ8, Q96MQ4, Q9H0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.