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Protein

Coiled-coil domain-containing protein 142

Gene

CCDC142

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 142
Gene namesi
Name:CCDC142
ORF Names:PSEC0243
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25889. CCDC142.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381450.

Polymorphism and mutation databases

BioMutaiCCDC142.
DMDMi121940584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Coiled-coil domain-containing protein 142PRO_0000311260Add
BLAST

Proteomic databases

EPDiQ17RM4.
PaxDbiQ17RM4.
PRIDEiQ17RM4.

Expressioni

Gene expression databases

BgeeiQ17RM4.
CleanExiHS_CCDC142.
ExpressionAtlasiQ17RM4. baseline and differential.
GenevisibleiQ17RM4. HS.

Organism-specific databases

HPAiHPA056946.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000290418.

Structurei

3D structure databases

ProteinModelPortaliQ17RM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 11024Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKX. Eukaryota.
ENOG4111G4R. LUCA.
GeneTreeiENSGT00390000009871.
HOGENOMiHOG000082479.
HOVERGENiHBG095606.
InParanoidiQ17RM4.
OMAiCARHLQA.
OrthoDBiEOG7XPZ66.
PhylomeDBiQ17RM4.
TreeFamiTF328445.

Family and domain databases

InterProiIPR026700. CCDC142.
[Graphical view]
PANTHERiPTHR21436. PTHR21436. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17RM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQASRSGSL PPLVIVPPLR AQPGGTGEEQ WERSRTGGLR WEVHCWPSGT
60 70 80 90 100
SGGTPWWPTP ADVSEDYEAD AAAWRRGPAG GGPIPPALQR LRAVLLRLHR
110 120 130 140 150
EREQLLQARD CAYHLQSAVR LMKTLSPGSP SGGPSPLPQW CRDLQLHPSQ
160 170 180 190 200
GAVLRIGPGE TLEPLLLARP IGLAAQCLEA VIEMQLRALG REPASPGLSS
210 220 230 240 250
QLAELLFALP AYHTLQRKAL SHVPGAARPF PTSRVLRLLT GERGCQVASR
260 270 280 290 300
LDEALQGSAL RDQLRRRCQE EGDLLPGLLG LVGGVAGSAS CGLGLGGAGA
310 320 330 340 350
LWSQYWTLLW AACAQSLDLN LGPWRDPRAT AQQLSQALGQ ASLPQECEKE
360 370 380 390 400
LASLCHRLLH QSLIWSWDQG FCQALGSALG GQSSLPTSSG TAELLQQLFP
410 420 430 440 450
PLLDALREPR LRRIFCQPAD PAPVALGLCT LQTTLLWFLG RAQQYLAAWD
460 470 480 490 500
PASFLLLIQK DLPPLLHEAE ALYSLASEES LALEVEQQLG LEIQKLTAQI
510 520 530 540 550
QLLPEESLSV FSQECHKQAM QGFKLYMPRG RYWRLRLCPE PPSAPSEYAG
560 570 580 590 600
LVVRTVLEPV LQGLQGLPPQ AQAPALGQAL TAIVGAWLDH ILTHGIRFSL
610 620 630 640 650
QGALQLKQDF GVVRELLEEE QWSLSPDLRQ TLLMLSIFQQ LDGALLCLLQ
660 670 680 690 700
QPLPKSQVHR RPPCCCACQE VQTTKLPSSC LNSLESLEPP LQPGTSPAQT
710 720 730 740 750
GQLQSTLGGR GPSPEGYLVG NQQAWLALRQ HQRPRWHLPF FSCLGTSPES
Length:750
Mass (Da):81,643
Last modified:July 25, 2006 - v1
Checksum:i7A7C54ABB819936B
GO
Isoform 2 (identifier: Q17RM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-426: Missing.

Note: No experimental confirmation available.
Show »
Length:743
Mass (Da):80,979
Checksum:iD7324A185FAFA39C
GO
Isoform 3 (identifier: Q17RM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     666-750: Missing.

Note: No experimental confirmation available.
Show »
Length:665
Mass (Da):72,473
Checksum:iBF97BCB15D13513E
GO

Sequence cautioni

The sequence BAC11474.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti534 – 5341R → Q.
Corresponds to variant rs13385919 [ dbSNP | Ensembl ].
VAR_037210

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei420 – 4267Missing in isoform 2. 1 PublicationVSP_029497
Alternative sequencei666 – 75085Missing in isoform 3. 1 PublicationVSP_029498Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075543 mRNA. Translation: BAC11686.1.
BC117269 mRNA. Translation: AAI17270.1.
BC143398 mRNA. Translation: AAI43399.1.
AK075209 mRNA. Translation: BAC11474.1. Different initiation.
CCDSiCCDS1945.1. [Q17RM4-2]
RefSeqiNP_116168.3. NM_032779.3. [Q17RM4-2]
UniGeneiHs.430199.

Genome annotation databases

EnsembliENST00000290418; ENSP00000290418; ENSG00000135637. [Q17RM4-2]
ENST00000393965; ENSP00000377537; ENSG00000135637. [Q17RM4-1]
GeneIDi84865.
KEGGihsa:84865.
UCSCiuc002slq.4. human. [Q17RM4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075543 mRNA. Translation: BAC11686.1.
BC117269 mRNA. Translation: AAI17270.1.
BC143398 mRNA. Translation: AAI43399.1.
AK075209 mRNA. Translation: BAC11474.1. Different initiation.
CCDSiCCDS1945.1. [Q17RM4-2]
RefSeqiNP_116168.3. NM_032779.3. [Q17RM4-2]
UniGeneiHs.430199.

3D structure databases

ProteinModelPortaliQ17RM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000290418.

Polymorphism and mutation databases

BioMutaiCCDC142.
DMDMi121940584.

Proteomic databases

EPDiQ17RM4.
PaxDbiQ17RM4.
PRIDEiQ17RM4.

Protocols and materials databases

DNASUi84865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290418; ENSP00000290418; ENSG00000135637. [Q17RM4-2]
ENST00000393965; ENSP00000377537; ENSG00000135637. [Q17RM4-1]
GeneIDi84865.
KEGGihsa:84865.
UCSCiuc002slq.4. human. [Q17RM4-1]

Organism-specific databases

CTDi84865.
GeneCardsiCCDC142.
H-InvDBHIX0002186.
HGNCiHGNC:25889. CCDC142.
HPAiHPA056946.
neXtProtiNX_Q17RM4.
PharmGKBiPA162381450.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKX. Eukaryota.
ENOG4111G4R. LUCA.
GeneTreeiENSGT00390000009871.
HOGENOMiHOG000082479.
HOVERGENiHBG095606.
InParanoidiQ17RM4.
OMAiCARHLQA.
OrthoDBiEOG7XPZ66.
PhylomeDBiQ17RM4.
TreeFamiTF328445.

Miscellaneous databases

ChiTaRSiCCDC142. human.
GenomeRNAii84865.
NextBioi75131.
PROiQ17RM4.

Gene expression databases

BgeeiQ17RM4.
CleanExiHS_CCDC142.
ExpressionAtlasiQ17RM4. baseline and differential.
GenevisibleiQ17RM4. HS.

Family and domain databases

InterProiIPR026700. CCDC142.
[Graphical view]
PANTHERiPTHR21436. PTHR21436. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-750 (ISOFORM 3).
    Tissue: Placenta.

Entry informationi

Entry nameiCC142_HUMAN
AccessioniPrimary (citable) accession number: Q17RM4
Secondary accession number(s): B7ZKV5
, Q8NBJ3, Q8NBV2, Q96KA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.