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Protein

BTB/POZ domain-containing protein KCTD19

Gene

KCTD19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD19
Gene namesi
Name:KCTD19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24753. KCTD19.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168676.
PharmGKBiPA142671640.

Polymorphism and mutation databases

BioMutaiKCTD19.
DMDMi121948228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003135871 – 926BTB/POZ domain-containing protein KCTD19Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ17RG1.
PeptideAtlasiQ17RG1.
PRIDEiQ17RG1.

PTM databases

iPTMnetiQ17RG1.
PhosphoSitePlusiQ17RG1.

Expressioni

Gene expression databases

BgeeiENSG00000168676.
CleanExiHS_KCTD19.
ExpressionAtlasiQ17RG1. baseline and differential.
GenevisibleiQ17RG1. HS.

Organism-specific databases

HPAiHPA049310.
HPA053321.

Interactioni

Subunit structurei

Identified in a complex with ZNF541, HDAC1 and HSPA2.By similarity

Protein-protein interaction databases

BioGridi126971. 1 interactor.
STRINGi9606.ENSP00000305702.

Structurei

3D structure databases

ProteinModelPortaliQ17RG1.
SMRiQ17RG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 72BTB 1Add BLAST55
Domaini398 – 485BTB 2Add BLAST88

Sequence similaritiesi

Contains 2 BTB (POZ) domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
KOG2723. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000007606.
HOGENOMiHOG000113203.
HOVERGENiHBG108057.
InParanoidiQ17RG1.
OMAiCMFFEDS.
OrthoDBiEOG091G01DU.
PhylomeDBiQ17RG1.
TreeFamiTF315332.

Family and domain databases

InterProiIPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 3 hits.

Sequencei

Sequence statusi: Complete.

Q17RG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESGMAHES AEDLFHFNVG GWHFSVPRSK LSQFPDSLLW KEASALTSSE
60 70 80 90 100
SQRLFIDRDG STFRHVHYYL YTSKLSFSSC AELNLLYEQA LGLQLMPLLQ
110 120 130 140 150
TLDNLKEGKH HLRVRPADLP VAERASLNYW RTWKCISKPS EFPIKSPAFT
160 170 180 190 200
GLHDKAPLGL MDTPLLDTEE EVHYCFLPLD LVAKYPSLVT EDNLLWLAET
210 220 230 240 250
VALIECECSE FRFIVNFLRS QKILLPDNFS NIDVLEAEVE ILEIPALTEA
260 270 280 290 300
VRWYRMNMGG CSPTTCSPLS PGKGARTASL ESVKPLYTMA LGLLVKYPDS
310 320 330 340 350
ALGQLRIEST LDGSRLYITG NGVLFQHVKN WLGTCRLPLT ETISEVYELC
360 370 380 390 400
AFLDKRDITY EPIKVALKTH LEPRTLAPMD VLNEWTAEIT VYSPQQIIKV
410 420 430 440 450
YVGSHWYATT LQTLLKYPEL LSNPQRVYWI TYGQTLLIHG DGQMFRHILN
460 470 480 490 500
FLRLGKLFLP SEFKEWPLFC QEVEEYHIPS LSEALAQCEA YKSWTQEKES
510 520 530 540 550
ENEEAFSIRR LHVVTEGPGS LVEFSRDTKE TTAYMPVDFE DCSDRTPWNK
560 570 580 590 600
AKGNLVRSNQ MDEAEQYTRP IQVSLCRNAK RAGNPSTYSH CRGLCTNPGH
610 620 630 640 650
WGSHPESPPK KKCTTINLTQ KSETKDPPAT PMQKLISLVR EWDMVNCKQW
660 670 680 690 700
EFQPLTATRS SPLEEATLQL PLGSEAASQP STSAAWKAHS TASEKDPGPQ
710 720 730 740 750
AGAGAGAKDK GPEPTFKPYL PPKRAGTLKD WSKQRTKERE SPAPEQPLPE
760 770 780 790 800
ASEVDSLGVI LKVTHPPVVG SDGFCMFFED SIIYTTEMDN LRHTTPTASP
810 820 830 840 850
QPQEVTFLSF SLSWEEMFYA QKCHCFLADI IMDSIRQKDP KAITAKVVSL
860 870 880 890 900
ANRLWTLHIS PKQFVVDLLA ITGFKDDRHT QERLYSWVEL TLPFARKYGR
910 920
CMDLLIQRGL SRSVSYSILG KYLQED
Length:926
Mass (Da):104,938
Last modified:July 25, 2006 - v1
Checksum:i7F0E610073D551CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti579A → V in BAC05072 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049723750E → K.Corresponds to variant rs16957289dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097481 mRNA. Translation: BAC05072.1.
AK302748 mRNA. Translation: BAG63961.1.
BC117335 mRNA. Translation: AAI17336.1.
CCDSiCCDS42179.1.
RefSeqiNP_001094385.1. NM_001100915.1.
UniGeneiHs.299127.

Genome annotation databases

EnsembliENST00000304372; ENSP00000305702; ENSG00000168676.
GeneIDi146212.
KEGGihsa:146212.
UCSCiuc002esu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097481 mRNA. Translation: BAC05072.1.
AK302748 mRNA. Translation: BAG63961.1.
BC117335 mRNA. Translation: AAI17336.1.
CCDSiCCDS42179.1.
RefSeqiNP_001094385.1. NM_001100915.1.
UniGeneiHs.299127.

3D structure databases

ProteinModelPortaliQ17RG1.
SMRiQ17RG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126971. 1 interactor.
STRINGi9606.ENSP00000305702.

PTM databases

iPTMnetiQ17RG1.
PhosphoSitePlusiQ17RG1.

Polymorphism and mutation databases

BioMutaiKCTD19.
DMDMi121948228.

Proteomic databases

PaxDbiQ17RG1.
PeptideAtlasiQ17RG1.
PRIDEiQ17RG1.

Protocols and materials databases

DNASUi146212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304372; ENSP00000305702; ENSG00000168676.
GeneIDi146212.
KEGGihsa:146212.
UCSCiuc002esu.3. human.

Organism-specific databases

CTDi146212.
GeneCardsiKCTD19.
HGNCiHGNC:24753. KCTD19.
HPAiHPA049310.
HPA053321.
neXtProtiNX_Q17RG1.
OpenTargetsiENSG00000168676.
PharmGKBiPA142671640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
KOG2723. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000007606.
HOGENOMiHOG000113203.
HOVERGENiHBG108057.
InParanoidiQ17RG1.
OMAiCMFFEDS.
OrthoDBiEOG091G01DU.
PhylomeDBiQ17RG1.
TreeFamiTF315332.

Miscellaneous databases

ChiTaRSiKCTD19. human.
GenomeRNAii146212.
PROiQ17RG1.

Gene expression databases

BgeeiENSG00000168676.
CleanExiHS_KCTD19.
ExpressionAtlasiQ17RG1. baseline and differential.
GenevisibleiQ17RG1. HS.

Family and domain databases

InterProiIPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKCD19_HUMAN
AccessioniPrimary (citable) accession number: Q17RG1
Secondary accession number(s): B4DZ49, Q8N804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.