Unreviewed, UniProtKB/TrEMBL Q17RE6 (Q17RE6_HUMAN)

Names and origin

Protein names

Submitted name:
    TXNRD2 protein EMBL AAI17355.1

Gene names

Name:

TXNRD2 EMBL AAI17355.1

Organism

Homo sapiens (Human) EMBL AAI17355.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003691V0

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003691V0
Ligand	FAD RuleBase RU003691V0 RuleBase RU000401V1 Flavoprotein RuleBase RU003691V0 RuleBase RU000401V1
Molecular function	Oxidoreductase RuleBase RU003691V0 RuleBase RU000401V1
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q17RE6-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 74368729E45F1A45	FASTA	492	53,395
	10 20 30 40 50 60 MEDQAGQRDY DLLVVGGGSG GLACAKEAAQ LGRKVAVVDY VEPSPQGTRW GLGGTCVNVG 70 80 90 100 110 120 CIPKKLMHQA ALLGGLIQDA PNYGWEVAQP VPHDWRKMAE AVQNHVKSLN WGHRVQLQDR 130 140 150 160 170 180 KVKYFNIKAS FVDEHTVCGV AKGGKEILLS ADHIIIATGG RPRYPTHIEG ALEYGITSDD 190 200 210 220 230 240 IFWLKESPGK TLVVGASYVA LECAGFLTGI GLDTTIMMRS IPLRGFDQQM SSMVIEHMAS 250 260 270 280 290 300 HGTRFLRGCA PSRVRRLPDG QLQVTWEDST TGKEDTGTFD TVLWAIGRVP DTRSLNLEKA 310 320 330 340 350 360 GVDTSPDTQK ILVDSREATS VPHIYAIGDV VEGRPELTPT AIMAGRLLVQ RLFGGSSDLM 370 380 390 400 410 420 DYDNVPTTVF TPLEYGCVGL SEEEAVARHG QEHVEVYHAH YKPLEFTVAG RDASQCYVKM 430 440 450 460 470 480 VCLREPPQLV LGLHFLGPNA GEVTQGFALG IKCGASYAQV MRTVGIHPTC SEEVVKLRIS 490 KRSGLDPTVT GC

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pooled EMBL AAI17355.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC117354 mRNA. Translation: AAI17355.1.
UniGene	Hs.443430
3D structure databases
SMR	Q17RE6. Positions 7-488.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000184470. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:18155. TXNRD2.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q17RE6.
Gene expression databases
ArrayExpress	Q17RE6.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR012999. Pyr_OxRdtase_I_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR006338. Reduct_Se. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
PANTHER	PTHR22912:SF23. Reduct_Se. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01438. TGR. 1 hit.
PROSITE	PS00076. PYRIDINE_REDOX_1. 1 hit. [Graphical view]

Entry information

Entry name

Q17RE6_HUMAN

Accession

Primary (citable) accession number: Q17RE6

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)