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Protein

Synaptotagmin-16

Gene

SYT16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-16
Alternative name(s):
Chr14Syt
Synaptotagmin 14-like protein
Synaptotagmin XIV-related protein
Gene namesi
Name:SYT16
Synonyms:STREP14, SYT14L, SYT14R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23142. SYT16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi83851.
OpenTargetsiENSG00000139973.
PharmGKBiPA134964250.

Polymorphism and mutation databases

BioMutaiSYT16.
DMDMi313104017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002585841 – 645Synaptotagmin-16Add BLAST645

Proteomic databases

PaxDbiQ17RD7.
PRIDEiQ17RD7.

PTM databases

iPTMnetiQ17RD7.
PhosphoSitePlusiQ17RD7.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000139973.
CleanExiHS_SYT14L.
HS_SYT16.
GenevisibleiQ17RD7. HS.

Organism-specific databases

HPAiHPA004199.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-10238936,EBI-741181
PHC2Q8IXK03EBI-10238936,EBI-713786
RABAC1Q9UI145EBI-10238936,EBI-712367
RTN4Q9NQC33EBI-10238936,EBI-715945
ZBTB14O438293EBI-10238936,EBI-10176632

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123767. 17 interactors.
IntActiQ17RD7. 9 interactors.
STRINGi9606.ENSP00000394700.

Structurei

3D structure databases

ProteinModelPortaliQ17RD7.
SMRiQ17RD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 453C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini507 – 611C2 2PROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XT5D. LUCA.
GeneTreeiENSGT00560000077240.
HOGENOMiHOG000070178.
HOVERGENiHBG062897.
InParanoidiQ17RD7.
KOiK19328.
OMAiWSPEEQD.
OrthoDBiEOG091G099X.
PhylomeDBiQ17RD7.
TreeFamiTF351132.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028690. SYT16.
[Graphical view]
PANTHERiPTHR10024:SF113. PTHR10024:SF113. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17RD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLAMASQDV QNFFQPFSSW ISRVYEALQQ AGDMLSASLV NISKQDSKLS
60 70 80 90 100
DKLDQDLDNI QIQETYFEDE EQDNDWSQED ANSLFLEVDH FSCCNSDLQD
110 120 130 140 150
SAQNSSPSLS QHAKDSCSTM SQWPNWASDD RKLPHVLSSI AEEEHHLEKQ
160 170 180 190 200
RSGLQHGFDS QLPGTLETVN GKKQVNSFGD DEELSTSSDS DEEVIKQFEI
210 220 230 240 250
SVSRSQSFRS VTSEKGKQTG LEQKPKFSRS LLTHGEDGTE VSACEDLDGA
260 270 280 290 300
SQRRYSENLS YGEDDHIPAH SQSPCERGDA KHHGTSHQES SVVQSLRRQS
310 320 330 340 350
TEGSLEMETA FNSRGFEDSY ATDSSSMWSP EEQDRTNLQV PSGVSEPISK
360 370 380 390 400
CGDLDVIFEY RAASQKLTVT IVRAQGLPDK DRSGVNSWQV HVVLLPGKKH
410 420 430 440 450
RGRTNIQRGP NPVFREKVTF AKLEPRDVAA CAVRFRLYAA RKMTRERMMG
460 470 480 490 500
EKLFYLSHLH PEGEMKVTLV LEPRSNISSG GSPLSPSAVS HSDSTSSTQS
510 520 530 540 550
LSHGGAPELL VGLSYNATTG RLSVEMIKGS HFRNLAVNRA PDTYGKLFLL
560 570 580 590 600
NSVGQEMSRC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT LMISVYNRRT
610 620 630 640
MKRKEMIGWI ALGQNSSGEE EQDHWEEMKE TKGQQICRWH TLLES
Length:645
Mass (Da):72,274
Last modified:November 30, 2010 - v2
Checksum:iA9E11164542AAAAE
GO
Isoform 2 (identifier: Q17RD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-331: Missing.

Show »
Length:625
Mass (Da):70,039
Checksum:iA0C5FF2E7231293B
GO
Isoform 3 (identifier: Q17RD7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,824
Checksum:iAC3B6BEE011868ED
GO
Isoform 4 (identifier: Q17RD7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-383: EQDRTNLQVP...AQGLPDKDRS → ANLNLKRKGY...SQSPSQSVVT
     384-645: Missing.

Note: No experimental confirmation available.
Show »
Length:383
Mass (Da):42,800
Checksum:iD2DC06B06EE32A84
GO

Sequence cautioni

The sequence CAE85114 differs from that shown. Reason: Erroneous termination at position 72. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175V → I in BAC76810 (PubMed:12801916).Curated1
Sequence conflicti517A → V in CAE85114 (PubMed:15238157).Curated1
Sequence conflicti614Q → L in CAE85114 (PubMed:15238157).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02893010V → A.1 PublicationCorresponds to variant rs8019076dbSNPEnsembl.1
Natural variantiVAR_028931131R → L.1 PublicationCorresponds to variant rs17099370dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0213781 – 442Missing in isoform 3. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_021379312 – 331Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_057225332 – 383EQDRT…DKDRS → ANLNLKRKGYLLDVYCLSSP LLFTTSLHRRNRTGPICRCH PGSQSPSQSVVT in isoform 4. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_057226384 – 645Missing in isoform 4. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102949 mRNA. Translation: BAC76810.1.
AJ617628 mRNA. Translation: CAE85114.1. Sequence problems.
AK302919 mRNA. Translation: BAG64084.1.
AL356018 Genomic DNA. No translation available.
AL390816 Genomic DNA. No translation available.
BC040924 mRNA. Translation: AAH40924.1.
BC117363 mRNA. Translation: AAI17364.1.
BC143598 mRNA. Translation: AAI43599.1.
AJ303367 mRNA. Translation: CAC33889.1.
CCDSiCCDS45121.1. [Q17RD7-1]
RefSeqiNP_114120.2. NM_031914.2. [Q17RD7-1]
XP_006720335.1. XM_006720272.3. [Q17RD7-1]
XP_011535521.1. XM_011537219.1. [Q17RD7-1]
XP_016877182.1. XM_017021693.1. [Q17RD7-1]
XP_016877183.1. XM_017021694.1. [Q17RD7-1]
XP_016877184.1. XM_017021695.1. [Q17RD7-1]
UniGeneiHs.404139.
Hs.713240.

Genome annotation databases

EnsembliENST00000430451; ENSP00000394700; ENSG00000139973. [Q17RD7-3]
ENST00000555409; ENSP00000451035; ENSG00000139973. [Q17RD7-4]
ENST00000568344; ENSP00000478637; ENSG00000139973. [Q17RD7-1]
GeneIDi83851.
KEGGihsa:83851.
UCSCiuc001xfu.2. human. [Q17RD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102949 mRNA. Translation: BAC76810.1.
AJ617628 mRNA. Translation: CAE85114.1. Sequence problems.
AK302919 mRNA. Translation: BAG64084.1.
AL356018 Genomic DNA. No translation available.
AL390816 Genomic DNA. No translation available.
BC040924 mRNA. Translation: AAH40924.1.
BC117363 mRNA. Translation: AAI17364.1.
BC143598 mRNA. Translation: AAI43599.1.
AJ303367 mRNA. Translation: CAC33889.1.
CCDSiCCDS45121.1. [Q17RD7-1]
RefSeqiNP_114120.2. NM_031914.2. [Q17RD7-1]
XP_006720335.1. XM_006720272.3. [Q17RD7-1]
XP_011535521.1. XM_011537219.1. [Q17RD7-1]
XP_016877182.1. XM_017021693.1. [Q17RD7-1]
XP_016877183.1. XM_017021694.1. [Q17RD7-1]
XP_016877184.1. XM_017021695.1. [Q17RD7-1]
UniGeneiHs.404139.
Hs.713240.

3D structure databases

ProteinModelPortaliQ17RD7.
SMRiQ17RD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123767. 17 interactors.
IntActiQ17RD7. 9 interactors.
STRINGi9606.ENSP00000394700.

PTM databases

iPTMnetiQ17RD7.
PhosphoSitePlusiQ17RD7.

Polymorphism and mutation databases

BioMutaiSYT16.
DMDMi313104017.

Proteomic databases

PaxDbiQ17RD7.
PRIDEiQ17RD7.

Protocols and materials databases

DNASUi83851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430451; ENSP00000394700; ENSG00000139973. [Q17RD7-3]
ENST00000555409; ENSP00000451035; ENSG00000139973. [Q17RD7-4]
ENST00000568344; ENSP00000478637; ENSG00000139973. [Q17RD7-1]
GeneIDi83851.
KEGGihsa:83851.
UCSCiuc001xfu.2. human. [Q17RD7-1]

Organism-specific databases

CTDi83851.
DisGeNETi83851.
GeneCardsiSYT16.
H-InvDBHIX0037646.
HGNCiHGNC:23142. SYT16.
HPAiHPA004199.
MIMi610950. gene.
neXtProtiNX_Q17RD7.
OpenTargetsiENSG00000139973.
PharmGKBiPA134964250.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XT5D. LUCA.
GeneTreeiENSGT00560000077240.
HOGENOMiHOG000070178.
HOVERGENiHBG062897.
InParanoidiQ17RD7.
KOiK19328.
OMAiWSPEEQD.
OrthoDBiEOG091G099X.
PhylomeDBiQ17RD7.
TreeFamiTF351132.

Miscellaneous databases

GenomeRNAii83851.
PROiQ17RD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139973.
CleanExiHS_SYT14L.
HS_SYT16.
GenevisibleiQ17RD7. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028690. SYT16.
[Graphical view]
PANTHERiPTHR10024:SF113. PTHR10024:SF113. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT16_HUMAN
AccessioniPrimary (citable) accession number: Q17RD7
Secondary accession number(s): B4DZH2
, B7ZL60, C9J8I3, Q707N2, Q7Z441, Q8IUU0, Q9BQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.