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Protein

LON peptidase N-terminal domain and RING finger protein 1

Gene

LONRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri123 – 159RING-type 1PROSITE-ProRule annotationAdd BLAST37
Zinc fingeri479 – 517RING-type 2PROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 1
Alternative name(s):
RING finger protein 191
Gene namesi
Name:LONRF1
Synonyms:RNF191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26302. LONRF1.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi91694.
OpenTargetsiENSG00000154359.
PharmGKBiPA128394743.

Polymorphism and mutation databases

BioMutaiLONRF1.
DMDMi257051033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002776691 – 773LON peptidase N-terminal domain and RING finger protein 1Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei431PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ17RB8.
PaxDbiQ17RB8.
PeptideAtlasiQ17RB8.
PRIDEiQ17RB8.

PTM databases

iPTMnetiQ17RB8.
PhosphoSitePlusiQ17RB8.

Expressioni

Gene expression databases

BgeeiENSG00000154359.
CleanExiHS_LONRF1.
ExpressionAtlasiQ17RB8. baseline and differential.
GenevisibleiQ17RB8. HS.

Organism-specific databases

HPAiHPA023584.
HPA024814.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124867. 38 interactors.
IntActiQ17RB8. 71 interactors.
STRINGi9606.ENSP00000381298.

Structurei

3D structure databases

ProteinModelPortaliQ17RB8.
SMRiQ17RB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 81TPR 1Add BLAST34
Repeati212 – 244TPR 2Add BLAST33
Repeati246 – 278TPR 3Add BLAST33
Repeati279 – 312TPR 4Add BLAST34
Domaini565 – 766Lon N-terminalPROSITE-ProRule annotationAdd BLAST202

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri123 – 159RING-type 1PROSITE-ProRule annotationAdd BLAST37
Zinc fingeri479 – 517RING-type 2PROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00440000033329.
HOGENOMiHOG000060199.
HOVERGENiHBG081924.
InParanoidiQ17RB8.
OMAiKNCLERC.
OrthoDBiEOG091G050D.
PhylomeDBiQ17RB8.
TreeFamiTF327043.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR003111. Lon_substr-bd.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF02190. LON_substr_bdg. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
SMARTiView protein in SMART
SM00464. LON. 1 hit.
SM00184. RING. 2 hits.
SM00028. TPR. 4 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS51787. LON_N. 1 hit.
PS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 2 hits.
PS50089. ZF_RING_2. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17RB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL
60 70 80 90 100
LLRRGELLAL GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR
110 120 130 140 150
HGLGWSAAPV AGADGGAGGL LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE
160 170 180 190 200
LRARCRLCRD RLPPATASAT DAEGTAPRPP PLAAAIAASD FRTSVVLNHL
210 220 230 240 250
AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA EPSDLIVKIY
260 270 280 290 300
RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ
310 320 330 340 350
LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR
360 370 380 390 400
PFDFHSVMEE SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE
410 420 430 440 450
MPAREDCLKR VSSEPVLSVQ EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ
460 470 480 490 500
GETPNEVCMF SLAYGDIPEE LIDVSDFECS LCMRLFFEPV TTPCGHSFCK
510 520 530 540 550
NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV KYLPDELSER
560 570 580 590 600
KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ
610 620 630 640 650
TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL
660 670 680 690 700
KRGMKDGYCT ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD
710 720 730 740 750
RFRSQILQHF GSMPEREENL QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM
760 770
KSLKERLTKI QHILTYFSRD QSK
Length:773
Mass (Da):86,725
Last modified:September 1, 2009 - v2
Checksum:iB151BEB07CF3638B
GO
Isoform 2 (identifier: Q17RB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-462: Missing.

Show »
Length:762
Mass (Da):85,473
Checksum:iA9A06A836F433EE5
GO

Sequence cautioni

The sequence AAI17382 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI17386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB85052 differs from that shown. Reason: Frameshift at position 463.Curated
The sequence BAG59741 differs from that shown. Reason: Frameshift at position 293.Curated
The sequence BAG62246 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti663I → V in BAG62246 (PubMed:14702039).Curated1
Sequence conflicti773K → E in BAG59741 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058706265I → L. Corresponds to variant dbSNP:rs1139354Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037971452 – 462Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123777 Genomic DNA. No translation available.
AK074329 mRNA. Translation: BAB85052.1. Frameshift.
AK297266 mRNA. Translation: BAG59741.1. Frameshift.
AK300538 mRNA. Translation: BAG62246.1. Different initiation.
BC004538 mRNA. Translation: AAH04538.2.
BC117381 mRNA. Translation: AAI17382.1. Different initiation.
BC117385 mRNA. Translation: AAI17386.1. Different initiation.
CCDSiCCDS5987.2. [Q17RB8-1]
RefSeqiNP_001316905.1. NM_001329976.1. [Q17RB8-2]
NP_689484.3. NM_152271.4. [Q17RB8-1]
UniGeneiHs.180178.

Genome annotation databases

EnsembliENST00000398246; ENSP00000381298; ENSG00000154359. [Q17RB8-1]
GeneIDi91694.
KEGGihsa:91694.
UCSCiuc003wwd.2. human. [Q17RB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLONF1_HUMAN
AccessioniPrimary (citable) accession number: Q17RB8
Secondary accession number(s): B4DM29
, B4DU84, Q8TEA0, Q9BSV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 1, 2009
Last modified: August 30, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations