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Q17RB8

- LONF1_HUMAN

UniProt

Q17RB8 - LONF1_HUMAN

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Protein
LON peptidase N-terminal domain and RING finger protein 1
Gene
LONRF1, RNF191
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri123 – 15937RING-type 1
Add
BLAST
Zinc fingeri479 – 51739RING-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP-dependent peptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 1
Alternative name(s):
RING finger protein 191
Gene namesi
Name:LONRF1
Synonyms:RNF191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:26302. LONRF1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773LON peptidase N-terminal domain and RING finger protein 1
PRO_0000277669Add
BLAST

Proteomic databases

PaxDbiQ17RB8.
PRIDEiQ17RB8.

PTM databases

PhosphoSiteiQ17RB8.

Expressioni

Gene expression databases

ArrayExpressiQ17RB8.
BgeeiQ17RB8.
CleanExiHS_LONRF1.
GenevestigatoriQ17RB8.

Organism-specific databases

HPAiHPA023584.
HPA024814.

Interactioni

Protein-protein interaction databases

BioGridi124867. 5 interactions.
IntActiQ17RB8. 3 interactions.
STRINGi9606.ENSP00000381298.

Structurei

3D structure databases

ProteinModelPortaliQ17RB8.
SMRiQ17RB8. Positions 118-149, 230-292, 477-539.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 8134TPR 1
Add
BLAST
Repeati212 – 24433TPR 2
Add
BLAST
Repeati246 – 27833TPR 3
Add
BLAST
Repeati279 – 31234TPR 4
Add
BLAST
Domaini567 – 766200Lon
Add
BLAST

Sequence similaritiesi

Contains 1 Lon domain.
Contains 4 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2802.
HOGENOMiHOG000060199.
HOVERGENiHBG081924.
InParanoidiQ17RB8.
OMAiGHSYCRR.
OrthoDBiEOG7S7SD6.
PhylomeDBiQ17RB8.
TreeFamiTF327043.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR003111. Pept_S16_N.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF02190. LON. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 2 hits.
PS50089. ZF_RING_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q17RB8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL    50
LLRRGELLAL GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR 100
HGLGWSAAPV AGADGGAGGL LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE 150
LRARCRLCRD RLPPATASAT DAEGTAPRPP PLAAAIAASD FRTSVVLNHL 200
AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA EPSDLIVKIY 250
RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ 300
LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR 350
PFDFHSVMEE SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE 400
MPAREDCLKR VSSEPVLSVQ EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ 450
GETPNEVCMF SLAYGDIPEE LIDVSDFECS LCMRLFFEPV TTPCGHSFCK 500
NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV KYLPDELSER 550
KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ 600
TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL 650
KRGMKDGYCT ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD 700
RFRSQILQHF GSMPEREENL QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM 750
KSLKERLTKI QHILTYFSRD QSK 773
Length:773
Mass (Da):86,725
Last modified:September 1, 2009 - v2
Checksum:iB151BEB07CF3638B
GO
Isoform 2 (identifier: Q17RB8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-462: Missing.

Show »
Length:762
Mass (Da):85,473
Checksum:iA9A06A836F433EE5
GO

Sequence cautioni

The sequence BAB85052.1 differs from that shown. Reason: Frameshift at position 463.
The sequence BAG59741.1 differs from that shown. Reason: Frameshift at position 293.
The sequence AAI17382.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI17386.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG62246.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti265 – 2651I → L.
Corresponds to variant rs1139354 [ dbSNP | Ensembl ].
VAR_058706

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei452 – 46211Missing in isoform 2.
VSP_037971Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti663 – 6631I → V in BAG62246. 1 Publication
Sequence conflicti773 – 7731K → E in BAG59741. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123777 Genomic DNA. No translation available.
AK074329 mRNA. Translation: BAB85052.1. Frameshift.
AK297266 mRNA. Translation: BAG59741.1. Frameshift.
AK300538 mRNA. Translation: BAG62246.1. Different initiation.
BC004538 mRNA. Translation: AAH04538.2.
BC117381 mRNA. Translation: AAI17382.1. Different initiation.
BC117385 mRNA. Translation: AAI17386.1. Different initiation.
CCDSiCCDS5987.2. [Q17RB8-1]
RefSeqiNP_689484.3. NM_152271.3. [Q17RB8-1]
XP_005273742.1. XM_005273685.1. [Q17RB8-2]
UniGeneiHs.180178.

Genome annotation databases

EnsembliENST00000398246; ENSP00000381298; ENSG00000154359. [Q17RB8-1]
ENST00000533751; ENSP00000432130; ENSG00000154359.
GeneIDi91694.
KEGGihsa:91694.
UCSCiuc003wwd.1. human. [Q17RB8-1]

Polymorphism databases

DMDMi257051033.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123777 Genomic DNA. No translation available.
AK074329 mRNA. Translation: BAB85052.1 . Frameshift.
AK297266 mRNA. Translation: BAG59741.1 . Frameshift.
AK300538 mRNA. Translation: BAG62246.1 . Different initiation.
BC004538 mRNA. Translation: AAH04538.2 .
BC117381 mRNA. Translation: AAI17382.1 . Different initiation.
BC117385 mRNA. Translation: AAI17386.1 . Different initiation.
CCDSi CCDS5987.2. [Q17RB8-1 ]
RefSeqi NP_689484.3. NM_152271.3. [Q17RB8-1 ]
XP_005273742.1. XM_005273685.1. [Q17RB8-2 ]
UniGenei Hs.180178.

3D structure databases

ProteinModelPortali Q17RB8.
SMRi Q17RB8. Positions 118-149, 230-292, 477-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124867. 5 interactions.
IntActi Q17RB8. 3 interactions.
STRINGi 9606.ENSP00000381298.

PTM databases

PhosphoSitei Q17RB8.

Polymorphism databases

DMDMi 257051033.

Proteomic databases

PaxDbi Q17RB8.
PRIDEi Q17RB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398246 ; ENSP00000381298 ; ENSG00000154359 . [Q17RB8-1 ]
ENST00000533751 ; ENSP00000432130 ; ENSG00000154359 .
GeneIDi 91694.
KEGGi hsa:91694.
UCSCi uc003wwd.1. human. [Q17RB8-1 ]

Organism-specific databases

CTDi 91694.
GeneCardsi GC08M012579.
HGNCi HGNC:26302. LONRF1.
HPAi HPA023584.
HPA024814.
neXtProti NX_Q17RB8.
PharmGKBi PA128394743.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2802.
HOGENOMi HOG000060199.
HOVERGENi HBG081924.
InParanoidi Q17RB8.
OMAi GHSYCRR.
OrthoDBi EOG7S7SD6.
PhylomeDBi Q17RB8.
TreeFami TF327043.

Miscellaneous databases

GenomeRNAii 91694.
NextBioi 77403.
PROi Q17RB8.

Gene expression databases

ArrayExpressi Q17RB8.
Bgeei Q17RB8.
CleanExi HS_LONRF1.
Genevestigatori Q17RB8.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
3.30.40.10. 2 hits.
InterProi IPR003111. Pept_S16_N.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF02190. LON. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 2 hits.
SM00028. TPR. 3 hits.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 1 hit.
PROSITEi PS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 2 hits.
PS50089. ZF_RING_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-773 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-773 (ISOFORM 2).
    Tissue: Hepatoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-773 (ISOFORM 1).
    Tissue: Brain and Ovary.

Entry informationi

Entry nameiLONF1_HUMAN
AccessioniPrimary (citable) accession number: Q17RB8
Secondary accession number(s): B4DM29
, B4DU84, Q8TEA0, Q9BSV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 1, 2009
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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