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Q17RB8 (LONF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LON peptidase N-terminal domain and RING finger protein 1
Alternative name(s):
RING finger protein 191
Gene names
Name:LONRF1
Synonyms:RNF191
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length773 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Lon domain.

Contains 2 RING-type zinc fingers.

Contains 4 TPR repeats.

Sequence caution

The sequence AAI17382.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI17386.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB85052.1 differs from that shown. Reason: Frameshift at position 463.

The sequence BAG59741.1 differs from that shown. Reason: Frameshift at position 293.

The sequence BAG62246.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
TPR repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q17RB8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q17RB8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     452-462: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 773773LON peptidase N-terminal domain and RING finger protein 1
PRO_0000277669

Regions

Repeat48 – 8134TPR 1
Repeat212 – 24433TPR 2
Repeat246 – 27833TPR 3
Repeat279 – 31234TPR 4
Domain567 – 766200Lon
Zinc finger123 – 15937RING-type 1
Zinc finger479 – 51739RING-type 2

Natural variations

Alternative sequence452 – 46211Missing in isoform 2.
VSP_037971
Natural variant2651I → L.
Corresponds to variant rs1139354 [ dbSNP | Ensembl ].
VAR_058706

Experimental info

Sequence conflict6631I → V in BAG62246. Ref.2
Sequence conflict7731K → E in BAG59741. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 1, 2009. Version 2.
Checksum: B151BEB07CF3638B

FASTA77386,725
        10         20         30         40         50         60 
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL LLRRGELLAL 

        70         80         90        100        110        120 
GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR HGLGWSAAPV AGADGGAGGL 

       130        140        150        160        170        180 
LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE LRARCRLCRD RLPPATASAT DAEGTAPRPP 

       190        200        210        220        230        240 
PLAAAIAASD FRTSVVLNHL AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA 

       250        260        270        280        290        300 
EPSDLIVKIY RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ 

       310        320        330        340        350        360 
LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR PFDFHSVMEE 

       370        380        390        400        410        420 
SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE MPAREDCLKR VSSEPVLSVQ 

       430        440        450        460        470        480 
EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ GETPNEVCMF SLAYGDIPEE LIDVSDFECS 

       490        500        510        520        530        540 
LCMRLFFEPV TTPCGHSFCK NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV 

       550        560        570        580        590        600 
KYLPDELSER KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ 

       610        620        630        640        650        660 
TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL KRGMKDGYCT 

       670        680        690        700        710        720 
ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD RFRSQILQHF GSMPEREENL 

       730        740        750        760        770 
QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM KSLKERLTKI QHILTYFSRD QSK 

« Hide

Isoform 2 [UniParc].

Checksum: A9A06A836F433EE5
Show »

FASTA76285,473

References

[1]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-773 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-773 (ISOFORM 2).
Tissue: Hepatoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-773 (ISOFORM 1).
Tissue: Brain and Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC123777 Genomic DNA. No translation available.
AK074329 mRNA. Translation: BAB85052.1. Frameshift.
AK297266 mRNA. Translation: BAG59741.1. Frameshift.
AK300538 mRNA. Translation: BAG62246.1. Different initiation.
BC004538 mRNA. Translation: AAH04538.2.
BC117381 mRNA. Translation: AAI17382.1. Different initiation.
BC117385 mRNA. Translation: AAI17386.1. Different initiation.
RefSeqNP_689484.3. NM_152271.3.
XP_005273742.1. XM_005273685.1.
UniGeneHs.180178.

3D structure databases

ProteinModelPortalQ17RB8.
SMRQ17RB8. Positions 41-78, 223-325, 475-521, 567-666.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124867. 5 interactions.
IntActQ17RB8. 3 interactions.
STRING9606.ENSP00000381298.

PTM databases

PhosphoSiteQ17RB8.

Polymorphism databases

DMDM257051033.

Proteomic databases

PaxDbQ17RB8.
PRIDEQ17RB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398246; ENSP00000381298; ENSG00000154359. [Q17RB8-1]
ENST00000533751; ENSP00000432130; ENSG00000154359.
GeneID91694.
KEGGhsa:91694.
UCSCuc003wwd.1. human. [Q17RB8-1]

Organism-specific databases

CTD91694.
GeneCardsGC08M012579.
HGNCHGNC:26302. LONRF1.
HPAHPA023584.
HPA024814.
neXtProtNX_Q17RB8.
PharmGKBPA128394743.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2802.
HOGENOMHOG000060199.
HOVERGENHBG081924.
InParanoidQ17RB8.
OMAGHSYCRR.
OrthoDBEOG7S7SD6.
PhylomeDBQ17RB8.
TreeFamTF327043.

Gene expression databases

ArrayExpressQ17RB8.
BgeeQ17RB8.
CleanExHS_LONRF1.
GenevestigatorQ17RB8.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
3.30.40.10. 2 hits.
InterProIPR003111. Pept_S16_N.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF02190. LON. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 2 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMSSF88697. SSF88697. 1 hit.
PROSITEPS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 2 hits.
PS50089. ZF_RING_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi91694.
NextBio77403.
PROQ17RB8.

Entry information

Entry nameLONF1_HUMAN
AccessionPrimary (citable) accession number: Q17RB8
Secondary accession number(s): B4DM29 expand/collapse secondary AC list , B4DU84, Q8TEA0, Q9BSV1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 1, 2009
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM