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Q17RB8

- LONF1_HUMAN

UniProt

Q17RB8 - LONF1_HUMAN

Protein

LON peptidase N-terminal domain and RING finger protein 1

Gene

LONRF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri123 – 15937RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri479 – 51739RING-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP-dependent peptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 1
    Alternative name(s):
    RING finger protein 191
    Gene namesi
    Name:LONRF1
    Synonyms:RNF191
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26302. LONRF1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394743.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773LON peptidase N-terminal domain and RING finger protein 1PRO_0000277669Add
    BLAST

    Proteomic databases

    PaxDbiQ17RB8.
    PRIDEiQ17RB8.

    PTM databases

    PhosphoSiteiQ17RB8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ17RB8.
    BgeeiQ17RB8.
    CleanExiHS_LONRF1.
    GenevestigatoriQ17RB8.

    Organism-specific databases

    HPAiHPA023584.
    HPA024814.

    Interactioni

    Protein-protein interaction databases

    BioGridi124867. 5 interactions.
    IntActiQ17RB8. 3 interactions.
    STRINGi9606.ENSP00000381298.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17RB8.
    SMRiQ17RB8. Positions 118-149, 230-292, 477-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati48 – 8134TPR 1Add
    BLAST
    Repeati212 – 24433TPR 2Add
    BLAST
    Repeati246 – 27833TPR 3Add
    BLAST
    Repeati279 – 31234TPR 4Add
    BLAST
    Domaini567 – 766200LonAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Lon domain.Curated
    Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
    Contains 4 TPR repeats.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri123 – 15937RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri479 – 51739RING-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, TPR repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2802.
    HOGENOMiHOG000060199.
    HOVERGENiHBG081924.
    InParanoidiQ17RB8.
    OMAiGHSYCRR.
    OrthoDBiEOG7S7SD6.
    PhylomeDBiQ17RB8.
    TreeFamiTF327043.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    3.30.40.10. 2 hits.
    InterProiIPR003111. Pept_S16_N.
    IPR015947. PUA-like_domain.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF02190. LON. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 2 hits.
    SM00028. TPR. 3 hits.
    [Graphical view]
    SUPFAMiSSF88697. SSF88697. 1 hit.
    PROSITEiPS50293. TPR_REGION. 1 hit.
    PS00518. ZF_RING_1. 2 hits.
    PS50089. ZF_RING_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q17RB8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL    50
    LLRRGELLAL GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR 100
    HGLGWSAAPV AGADGGAGGL LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE 150
    LRARCRLCRD RLPPATASAT DAEGTAPRPP PLAAAIAASD FRTSVVLNHL 200
    AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA EPSDLIVKIY 250
    RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ 300
    LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR 350
    PFDFHSVMEE SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE 400
    MPAREDCLKR VSSEPVLSVQ EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ 450
    GETPNEVCMF SLAYGDIPEE LIDVSDFECS LCMRLFFEPV TTPCGHSFCK 500
    NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV KYLPDELSER 550
    KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ 600
    TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL 650
    KRGMKDGYCT ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD 700
    RFRSQILQHF GSMPEREENL QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM 750
    KSLKERLTKI QHILTYFSRD QSK 773
    Length:773
    Mass (Da):86,725
    Last modified:September 1, 2009 - v2
    Checksum:iB151BEB07CF3638B
    GO
    Isoform 2 (identifier: Q17RB8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         452-462: Missing.

    Show »
    Length:762
    Mass (Da):85,473
    Checksum:iA9A06A836F433EE5
    GO

    Sequence cautioni

    The sequence BAB85052.1 differs from that shown. Reason: Frameshift at position 463.
    The sequence BAG59741.1 differs from that shown. Reason: Frameshift at position 293.
    The sequence AAI17382.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI17386.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG62246.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti663 – 6631I → V in BAG62246. (PubMed:14702039)Curated
    Sequence conflicti773 – 7731K → E in BAG59741. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti265 – 2651I → L.
    Corresponds to variant rs1139354 [ dbSNP | Ensembl ].
    VAR_058706

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei452 – 46211Missing in isoform 2. 1 PublicationVSP_037971Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123777 Genomic DNA. No translation available.
    AK074329 mRNA. Translation: BAB85052.1. Frameshift.
    AK297266 mRNA. Translation: BAG59741.1. Frameshift.
    AK300538 mRNA. Translation: BAG62246.1. Different initiation.
    BC004538 mRNA. Translation: AAH04538.2.
    BC117381 mRNA. Translation: AAI17382.1. Different initiation.
    BC117385 mRNA. Translation: AAI17386.1. Different initiation.
    CCDSiCCDS5987.2. [Q17RB8-1]
    RefSeqiNP_689484.3. NM_152271.3. [Q17RB8-1]
    XP_005273742.1. XM_005273685.1. [Q17RB8-2]
    UniGeneiHs.180178.

    Genome annotation databases

    EnsembliENST00000398246; ENSP00000381298; ENSG00000154359. [Q17RB8-1]
    ENST00000533751; ENSP00000432130; ENSG00000154359.
    GeneIDi91694.
    KEGGihsa:91694.
    UCSCiuc003wwd.1. human. [Q17RB8-1]

    Polymorphism databases

    DMDMi257051033.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123777 Genomic DNA. No translation available.
    AK074329 mRNA. Translation: BAB85052.1 . Frameshift.
    AK297266 mRNA. Translation: BAG59741.1 . Frameshift.
    AK300538 mRNA. Translation: BAG62246.1 . Different initiation.
    BC004538 mRNA. Translation: AAH04538.2 .
    BC117381 mRNA. Translation: AAI17382.1 . Different initiation.
    BC117385 mRNA. Translation: AAI17386.1 . Different initiation.
    CCDSi CCDS5987.2. [Q17RB8-1 ]
    RefSeqi NP_689484.3. NM_152271.3. [Q17RB8-1 ]
    XP_005273742.1. XM_005273685.1. [Q17RB8-2 ]
    UniGenei Hs.180178.

    3D structure databases

    ProteinModelPortali Q17RB8.
    SMRi Q17RB8. Positions 118-149, 230-292, 477-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124867. 5 interactions.
    IntActi Q17RB8. 3 interactions.
    STRINGi 9606.ENSP00000381298.

    PTM databases

    PhosphoSitei Q17RB8.

    Polymorphism databases

    DMDMi 257051033.

    Proteomic databases

    PaxDbi Q17RB8.
    PRIDEi Q17RB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398246 ; ENSP00000381298 ; ENSG00000154359 . [Q17RB8-1 ]
    ENST00000533751 ; ENSP00000432130 ; ENSG00000154359 .
    GeneIDi 91694.
    KEGGi hsa:91694.
    UCSCi uc003wwd.1. human. [Q17RB8-1 ]

    Organism-specific databases

    CTDi 91694.
    GeneCardsi GC08M012579.
    HGNCi HGNC:26302. LONRF1.
    HPAi HPA023584.
    HPA024814.
    neXtProti NX_Q17RB8.
    PharmGKBi PA128394743.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2802.
    HOGENOMi HOG000060199.
    HOVERGENi HBG081924.
    InParanoidi Q17RB8.
    OMAi GHSYCRR.
    OrthoDBi EOG7S7SD6.
    PhylomeDBi Q17RB8.
    TreeFami TF327043.

    Miscellaneous databases

    GenomeRNAii 91694.
    NextBioi 77403.
    PROi Q17RB8.

    Gene expression databases

    ArrayExpressi Q17RB8.
    Bgeei Q17RB8.
    CleanExi HS_LONRF1.
    Genevestigatori Q17RB8.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    3.30.40.10. 2 hits.
    InterProi IPR003111. Pept_S16_N.
    IPR015947. PUA-like_domain.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF02190. LON. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 2 hits.
    SM00028. TPR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF88697. SSF88697. 1 hit.
    PROSITEi PS50293. TPR_REGION. 1 hit.
    PS00518. ZF_RING_1. 2 hits.
    PS50089. ZF_RING_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-773 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-773 (ISOFORM 2).
      Tissue: Hepatoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-773 (ISOFORM 1).
      Tissue: Brain and Ovary.

    Entry informationi

    Entry nameiLONF1_HUMAN
    AccessioniPrimary (citable) accession number: Q17RB8
    Secondary accession number(s): B4DM29
    , B4DU84, Q8TEA0, Q9BSV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3