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Protein

Retrotransposon Gag-like protein 8B

Gene

RTL8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

RTL8B is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 8BImported
Alternative name(s):
Mammalian retrotransposon derived protein 8B
Gene namesi
Name:RTL8B
Synonyms:CXX1C, FAM127C, MAR8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000212747.4.
HGNCiHGNC:33156. RTL8B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212747.
PharmGKBiPA162385922.

Polymorphism and mutation databases

BioMutaiFAM127C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003116941 – 113Retrotransposon Gag-like protein 8BAdd BLAST113

Proteomic databases

MaxQBiQ17RB0.
PaxDbiQ17RB0.
PeptideAtlasiQ17RB0.
PRIDEiQ17RB0.

PTM databases

iPTMnetiQ17RB0.
PhosphoSitePlusiQ17RB0.

Expressioni

Gene expression databases

BgeeiENSG00000212747.
CleanExiHS_FAM127C.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi137545. 8 interactors.
IntActiQ17RB0. 10 interactors.
STRINGi9606.ENSP00000375268.

Structurei

3D structure databases

ProteinModelPortaliQ17RB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ17RB0.
OMAiWGFLAEM.
OrthoDBiEOG091G02TH.
PhylomeDBiQ17RB0.
TreeFamiTF337843.

Family and domain databases

InterProiView protein in InterPro
IPR032549. DUF4939.
IPR032567. LDOC1-rel.
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiView protein in Pfam
PF16297. DUF4939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17RB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGRVQLMKA LLARPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIKKESPL LSDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,246
Last modified:July 25, 2006 - v1
Checksum:i422EDCABF6CA9205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. No translation available.
BC113720 mRNA. Translation: AAI13721.1.
BC117393 mRNA. Translation: AAI17394.1.
CCDSiCCDS43996.1.
RefSeqiNP_001071641.1. NM_001078173.1.
UniGeneiHs.378813.

Genome annotation databases

EnsembliENST00000391440; ENSP00000375268; ENSG00000212747.
GeneIDi441518.
KEGGihsa:441518.
UCSCiuc004eyc.2. human.

Similar proteinsi

Entry informationi

Entry nameiRTL8B_HUMAN
AccessioniPrimary (citable) accession number: Q17RB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families