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Protein

Protein FAM127C

Gene

FAM127C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM127C
Alternative name(s):
Mammalian retrotransposon derived protein 8B
Gene namesi
Name:FAM127C
Synonyms:CXX1C, MAR8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33156. FAM127C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385922.

Polymorphism and mutation databases

BioMutaiFAM127C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Protein FAM127CPRO_0000311694Add
BLAST

Proteomic databases

EPDiQ17RB0.
PaxDbiQ17RB0.
PeptideAtlasiQ17RB0.
PRIDEiQ17RB0.

PTM databases

iPTMnetiQ17RB0.
PhosphoSiteiQ17RB0.

Expressioni

Gene expression databases

BgeeiQ17RB0.
CleanExiHS_FAM127C.

Organism-specific databases

HPAiHPA042173.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-10238588,EBI-3905054
CCDC102BA1A4H13EBI-10238588,EBI-10171570
KRT13A1A4E93EBI-10238588,EBI-10171552
PEG10Q86TG73EBI-10238588,EBI-2858265
TADA2AO754783EBI-10238588,EBI-742268
UBQLN1Q9UMX03EBI-10238588,EBI-741480
UBQLN1Q9UMX0-23EBI-10238588,EBI-10173939

Protein-protein interaction databases

BioGridi137545. 7 interactions.
IntActiQ17RB0. 7 interactions.
STRINGi9606.ENSP00000375268.

Structurei

3D structure databases

ProteinModelPortaliQ17RB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ17RB0.
OMAiWGFLAEM.
OrthoDBiEOG722JBJ.
PhylomeDBiQ17RB0.
TreeFamiTF337843.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17RB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGRVQLMKA LLARPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIKKESPL LSDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,246
Last modified:July 25, 2006 - v1
Checksum:i422EDCABF6CA9205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAD92616.2.
BC113720 mRNA. Translation: AAI13721.1.
BC117393 mRNA. Translation: AAI17394.1.
CCDSiCCDS43996.1.
RefSeqiNP_001071641.1. NM_001078173.1.
UniGeneiHs.378813.

Genome annotation databases

EnsembliENST00000391440; ENSP00000375268; ENSG00000212747.
GeneIDi441518.
KEGGihsa:441518.
UCSCiuc004eyc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAD92616.2.
BC113720 mRNA. Translation: AAI13721.1.
BC117393 mRNA. Translation: AAI17394.1.
CCDSiCCDS43996.1.
RefSeqiNP_001071641.1. NM_001078173.1.
UniGeneiHs.378813.

3D structure databases

ProteinModelPortaliQ17RB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137545. 7 interactions.
IntActiQ17RB0. 7 interactions.
STRINGi9606.ENSP00000375268.

PTM databases

iPTMnetiQ17RB0.
PhosphoSiteiQ17RB0.

Polymorphism and mutation databases

BioMutaiFAM127C.

Proteomic databases

EPDiQ17RB0.
PaxDbiQ17RB0.
PeptideAtlasiQ17RB0.
PRIDEiQ17RB0.

Protocols and materials databases

DNASUi441518.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391440; ENSP00000375268; ENSG00000212747.
GeneIDi441518.
KEGGihsa:441518.
UCSCiuc004eyc.2. human.

Organism-specific databases

CTDi441518.
GeneCardsiFAM127C.
HGNCiHGNC:33156. FAM127C.
HPAiHPA042173.
neXtProtiNX_Q17RB0.
PharmGKBiPA162385922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ17RB0.
OMAiWGFLAEM.
OrthoDBiEOG722JBJ.
PhylomeDBiQ17RB0.
TreeFamiTF337843.

Miscellaneous databases

GenomeRNAii441518.
PROiQ17RB0.

Gene expression databases

BgeeiQ17RB0.
CleanExiHS_FAM127C.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF127C_HUMAN
AccessioniPrimary (citable) accession number: Q17RB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.