Q17RA0 (Q17RA0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Interleukin 6 signal transducer (Gp130, oncostatin M receptor) EMBL AAI17405.1

Gene names

Name:

IL6ST EMBL AAI17405.1

Organism

Homo sapiens (Human) EMBL AAI17405.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	918 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Receptor EMBL AAI17405.1
Gene Ontology (GO)
Biological_process	cytokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	cytokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q17RA0 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: FB7FBEEEC68742AC	FASTA	918	103,622
	10 20 30 40 50 60 MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV 70 80 90 100 110 120 NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI 130 140 150 160 170 180 ISGLPPEKPK NLSCIVNEGK KMRCEWDRGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT 190 200 210 220 230 240 SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL 250 260 270 280 290 300 KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 310 320 330 340 350 360 CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN 370 380 390 400 410 420 GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYVATL TVRNLVGKSD AAVLTIPACD 430 440 450 460 470 480 FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT 490 500 510 520 530 540 YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD 550 560 570 580 590 600 QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 610 620 630 640 650 660 KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK 670 680 690 700 710 720 SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN 730 740 750 760 770 780 TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS 790 800 810 820 830 840 ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV 850 860 870 880 890 900 NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 910 MPKSYLPQTV RQGGYMPQ

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI17405.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC117402 mRNA. Translation: AAI17403.1. BC117404 mRNA. Translation: AAI17405.1.
IPI	IPI00297124.
RefSeq	NP_002175.2. NM_002184.3.
UniGene	Hs.532082. Hs.706627.
3D structure databases
ProteinModelPortal	Q17RA0.
SMR	Q17RA0. Positions 24-325.
ModBase	Search...
Protein-protein interaction databases
STRING	Q17RA0.
Proteomic databases
PRIDE	Q17RA0.
Protocols and materials databases
DNASU	3572.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3572.
KEGG	hsa:3572.
Organism-specific databases
CTD	3572.
Phylogenomic databases
HOVERGEN	HBG052119.
KO	K05060.
Gene expression databases
ArrayExpress	Q17RA0.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR003961. Fibronectin_type3. IPR003529. Hematopoietin_rcpt_Gp130_CS. IPR013783. Ig-like_fold. IPR010457. IgC2-like_lig-bd. IPR015321. IL6_recept-bd. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF09240. IL6Ra-bind. 1 hit. PF06328. Lep_receptor_Ig. 1 hit. [Graphical view]
SMART	SM00060. FN3. 5 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 6 hits.
PROSITE	PS50853. FN3. 5 hits. PS01353. HEMATOPO_REC_L_F2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IL6ST. human.
GenomeRNAi	3572.
NextBio	13960.

Entry information

Entry name

Q17RA0_HUMAN

Accession

Primary (citable) accession number: Q17RA0

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	March 6, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.