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Protein
Submitted name:

Interleukin 6 signal transducer (Gp130, oncostatin M receptor)

Gene

IL6ST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 6 signal transducer (Gp130, oncostatin M receptor)Imported
Gene namesi
Name:IL6STImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei621 – 641HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501109791823 – 918Sequence analysisAdd BLAST896

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ17RA0. 4 interactors.

Structurei

3D structure databases

SMRiQ17RA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 324Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini329 – 424Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini426 – 517Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini518 – 613Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF1N. Eukaryota.
ENOG410YNQ4. LUCA.
HOVERGENiHBG052119.
KOiK05060.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 6 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. TypeI_recpt_CBD.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
SMARTiView protein in SMART
SM00060. FN3. 5 hits.
SUPFAMiSSF49265. SSF49265. 5 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17RA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
60 70 80 90 100
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
110 120 130 140 150
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDRGR
160 170 180 190 200
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
210 220 230 240 250
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
260 270 280 290 300
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
310 320 330 340 350
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV
360 370 380 390 400
WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYVATL
410 420 430 440 450
TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV
460 470 480 490 500
KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY
510 520 530 540 550
ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF
560 570 580 590 600
IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG
610 620 630 640 650
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH
660 670 680 690 700
IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND
710 720 730 740 750
KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS
760 770 780 790 800
QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD
810 820 830 840 850
HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ
860 870 880 890 900
QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG
910
MPKSYLPQTV RQGGYMPQ
Length:918
Mass (Da):103,622
Last modified:July 25, 2006 - v1
Checksum:iFB7FBEEEC68742AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117402 mRNA. Translation: AAI17403.1.
BC117404 mRNA. Translation: AAI17405.1.
RefSeqiNP_002175.2. NM_002184.3.
UniGeneiHs.532082.
Hs.706627.

Genome annotation databases

GeneIDi3572.
KEGGihsa:3572.

Similar proteinsi

Entry informationi

Entry nameiQ17RA0_HUMAN
AccessioniPrimary (citable) accession number: Q17RA0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.