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Protein

Zinc finger protein 827

Gene

ZNF827

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri374 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri817 – 839C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri845 – 867C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 952C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 827
Gene namesi
Name:ZNF827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27193. ZNF827.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi152485.
OpenTargetsiENSG00000151612.
PharmGKBiPA162410714.

Polymorphism and mutation databases

BioMutaiZNF827.
DMDMi121945543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258891 – 1081Zinc finger protein 827Add BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki523Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki597Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ17R98.
PaxDbiQ17R98.
PeptideAtlasiQ17R98.
PRIDEiQ17R98.

PTM databases

iPTMnetiQ17R98.
PhosphoSitePlusiQ17R98.
SwissPalmiQ17R98.

Expressioni

Gene expression databases

BgeeiENSG00000151612.
CleanExiHS_ZNF827.
ExpressionAtlasiQ17R98. baseline and differential.
GenevisibleiQ17R98. HS.

Organism-specific databases

HPAiHPA021166.
HPA057275.

Interactioni

Protein-protein interaction databases

BioGridi127447. 7 interactors.
DIPiDIP-61048N.
IntActiQ17R98. 2 interactors.
STRINGi9606.ENSP00000368761.

Structurei

3D structure databases

ProteinModelPortaliQ17R98.
SMRiQ17R98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 354Pro-richAdd BLAST44
Compositional biasi961 – 972Poly-SerAdd BLAST12

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri374 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri817 – 839C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri845 – 867C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 952C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132304.
HOGENOMiHOG000082483.
HOVERGENiHBG066774.
InParanoidiQ17R98.
OrthoDBiEOG091G01DQ.
PhylomeDBiQ17R98.
TreeFamiTF333046.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17R98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRKQEQPK RLPSHVSRQE EAEGELSEGE HWYGNSSETP SEASYGEVQE
60 70 80 90 100
NYKLSLEDRI QEQSTSPDTS LGSTTPSSHT LELVALDSEV LRDSLQCQDH
110 120 130 140 150
LSPGVSSLCD DDPGSNKPLS SNLRRLLEAG SLKLDAAATA NGRVESPVNV
160 170 180 190 200
GSNLSFSPPS HHAQQLSVLA RKLAEKQEQN DQYTPSNRFI WNQGKWLPNS
210 220 230 240 250
TTTCSLSPDS AILKLKAAAN AVLQDKSLTR TEETMRFESF SSPFSSQSAS
260 270 280 290 300
STLAALSKKV SERSLTPGQE HPPPASSFLS LASMTSSAAL LKEVAARAAG
310 320 330 340 350
SLLAEKSSLL PEDPLPPPPS EKKPEKVTPP PPPPPPPPPP PPPQSLELLL
360 370 380 390 400
LPVPKGRVSK PSNSASEEES GKPFQCPICG LVIKRKSYWK RHMVIHTGLK
410 420 430 440 450
SHQCPLCPFR CARKDNLKSH MKVHQHQDRG ETFQCQLCPF TSSRHFSLKL
460 470 480 490 500
HMRCHQHFLR TEAKVKEEIP DPDVKGSPHL SDSACLGQQR EGGGTELVGT
510 520 530 540 550
MMTSNTPERT SQGGAGVSPL LVKEEPKEDN GLPTSFTLNA ADRPANHTKL
560 570 580 590 600
KDPSEYVANS ASALFSQDIS VKMASDFLMK LSAANQKEPM NLNFKVKEEP
610 620 630 640 650
KEGESLSTTL PRSSYVFSPE SEVSAPGVSE DALKPQEGKG SVLRRDVSVK
660 670 680 690 700
AASELLMKLS AESYKETQMV KIKEEPMEVD IQDSHVSISP SRNVGYSTLI
710 720 730 740 750
GREKTEPLQK MPEGRVPPER NLFSQDISVK MASELLFQLS EKVSKEHNHT
760 770 780 790 800
KENTIRTTTS PFFSEDTFRQ SPFTSNSKEL LPSDSVLHGR ISAPETEKIV
810 820 830 840 850
LEAGNGLPSW KFNDQLFPCD VCGKVFGRQQ TLSRHLSLHT EERKYKCHLC
860 870 880 890 900
PYAAKCRANL NQHLTVHSVK LVSTDTEDIV SAVTSEGSDG KKHPYYYSCH
910 920 930 940 950
VCGFETELNV QFVSHMSLHV DKEQWMFSIC CTACDFVTME EAEIKTHIGT
960 970 980 990 1000
KHTGEDRKTP SESNSPSSSS LSALSDSANS KDDSDGSQKN KGGNNLLVIS
1010 1020 1030 1040 1050
VMPGSQPSLN SEEKPEKGFE CVFCNFVCKT KNMFERHLQI HLITRMFECD
1060 1070 1080
VCHKFMKTPE QLLEHKKCHT VPTGGLNSGQ W
Length:1,081
Mass (Da):119,165
Last modified:July 25, 2006 - v1
Checksum:iBA32DF19FE700EFA
GO
Isoform 2 (identifier: Q17R98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1077-1077: N → K
     1078-1081: Missing.

Note: No experimental confirmation available.
Show »
Length:1,077
Mass (Da):118,721
Checksum:i09000EFA9DDC74CE
GO
Isoform 3 (identifier: Q17R98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-365: Missing.

Note: No experimental confirmation available.
Show »
Length:731
Mass (Da):81,863
Checksum:iB3958BAE22BADCE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15H → P in AAP97679 (Ref. 1) Curated1
Sequence conflicti39T → A in BAC03591 (PubMed:14702039).Curated1
Sequence conflicti164Q → R in BAC03591 (PubMed:14702039).Curated1
Sequence conflicti240F → L in BAC03591 (PubMed:14702039).Curated1
Sequence conflicti859N → D in AAP97679 (Ref. 1) Curated1
Sequence conflicti905E → G in BAC03591 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03246316 – 365Missing in isoform 3. 1 PublicationAdd BLAST350
Alternative sequenceiVSP_0324641077N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_0324651078 – 1081Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450485 mRNA. Translation: AAP97679.1.
AK091130 mRNA. Translation: BAC03591.1.
BC117407 mRNA. Translation: AAI17408.1.
BC143577 mRNA. Translation: AAI43578.1.
CCDSiCCDS34072.1. [Q17R98-2]
CCDS77968.1. [Q17R98-1]
RefSeqiNP_001293144.1. NM_001306215.1. [Q17R98-1]
NP_849157.2. NM_178835.4. [Q17R98-2]
XP_016863261.1. XM_017007772.1. [Q17R98-2]
XP_016863262.1. XM_017007773.1. [Q17R98-2]
XP_016863263.1. XM_017007774.1. [Q17R98-2]
XP_016863264.1. XM_017007775.1. [Q17R98-2]
UniGeneiHs.133916.
Hs.633543.

Genome annotation databases

EnsembliENST00000379448; ENSP00000368761; ENSG00000151612. [Q17R98-2]
ENST00000508784; ENSP00000421863; ENSG00000151612. [Q17R98-1]
GeneIDi152485.
KEGGihsa:152485.
UCSCiuc003ikm.4. human. [Q17R98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450485 mRNA. Translation: AAP97679.1.
AK091130 mRNA. Translation: BAC03591.1.
BC117407 mRNA. Translation: AAI17408.1.
BC143577 mRNA. Translation: AAI43578.1.
CCDSiCCDS34072.1. [Q17R98-2]
CCDS77968.1. [Q17R98-1]
RefSeqiNP_001293144.1. NM_001306215.1. [Q17R98-1]
NP_849157.2. NM_178835.4. [Q17R98-2]
XP_016863261.1. XM_017007772.1. [Q17R98-2]
XP_016863262.1. XM_017007773.1. [Q17R98-2]
XP_016863263.1. XM_017007774.1. [Q17R98-2]
XP_016863264.1. XM_017007775.1. [Q17R98-2]
UniGeneiHs.133916.
Hs.633543.

3D structure databases

ProteinModelPortaliQ17R98.
SMRiQ17R98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127447. 7 interactors.
DIPiDIP-61048N.
IntActiQ17R98. 2 interactors.
STRINGi9606.ENSP00000368761.

PTM databases

iPTMnetiQ17R98.
PhosphoSitePlusiQ17R98.
SwissPalmiQ17R98.

Polymorphism and mutation databases

BioMutaiZNF827.
DMDMi121945543.

Proteomic databases

MaxQBiQ17R98.
PaxDbiQ17R98.
PeptideAtlasiQ17R98.
PRIDEiQ17R98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379448; ENSP00000368761; ENSG00000151612. [Q17R98-2]
ENST00000508784; ENSP00000421863; ENSG00000151612. [Q17R98-1]
GeneIDi152485.
KEGGihsa:152485.
UCSCiuc003ikm.4. human. [Q17R98-1]

Organism-specific databases

CTDi152485.
DisGeNETi152485.
GeneCardsiZNF827.
HGNCiHGNC:27193. ZNF827.
HPAiHPA021166.
HPA057275.
neXtProtiNX_Q17R98.
OpenTargetsiENSG00000151612.
PharmGKBiPA162410714.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132304.
HOGENOMiHOG000082483.
HOVERGENiHBG066774.
InParanoidiQ17R98.
OrthoDBiEOG091G01DQ.
PhylomeDBiQ17R98.
TreeFamiTF333046.

Miscellaneous databases

ChiTaRSiZNF827. human.
GenomeRNAii152485.
PROiQ17R98.

Gene expression databases

BgeeiENSG00000151612.
CleanExiHS_ZNF827.
ExpressionAtlasiQ17R98. baseline and differential.
GenevisibleiQ17R98. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN827_HUMAN
AccessioniPrimary (citable) accession number: Q17R98
Secondary accession number(s): B7ZL52, Q7Z4S7, Q8N279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.