Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 827

Gene

ZNF827

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri374 – 39623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri817 – 83923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri845 – 86723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri897 – 91923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri929 – 95224C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1019 – 104123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1047 – 106923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 827
Gene namesi
Name:ZNF827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27193. ZNF827.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410714.

Polymorphism and mutation databases

BioMutaiZNF827.
DMDMi121945543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10811081Zinc finger protein 827PRO_0000325889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki466 – 466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki523 – 523Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki597 – 597Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki673 – 673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki673 – 673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki704 – 704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ17R98.
PaxDbiQ17R98.
PeptideAtlasiQ17R98.
PRIDEiQ17R98.

PTM databases

iPTMnetiQ17R98.
PhosphoSiteiQ17R98.
SwissPalmiQ17R98.

Expressioni

Gene expression databases

BgeeiENSG00000151612.
CleanExiHS_ZNF827.
ExpressionAtlasiQ17R98. baseline and differential.
GenevisibleiQ17R98. HS.

Organism-specific databases

HPAiHPA021166.
HPA057275.

Interactioni

Protein-protein interaction databases

BioGridi127447. 7 interactions.
DIPiDIP-61048N.
IntActiQ17R98. 2 interactions.
STRINGi9606.ENSP00000368761.

Structurei

3D structure databases

ProteinModelPortaliQ17R98.
SMRiQ17R98. Positions 365-456, 819-868, 897-960, 1005-1071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi311 – 35444Pro-richAdd
BLAST
Compositional biasi961 – 97212Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri374 – 39623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri817 – 83923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri845 – 86723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri897 – 91923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri929 – 95224C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1019 – 104123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1047 – 106923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125544.
HOGENOMiHOG000082483.
HOVERGENiHBG066774.
InParanoidiQ17R98.
OrthoDBiEOG091G01DQ.
PhylomeDBiQ17R98.
TreeFamiTF333046.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17R98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRKQEQPK RLPSHVSRQE EAEGELSEGE HWYGNSSETP SEASYGEVQE
60 70 80 90 100
NYKLSLEDRI QEQSTSPDTS LGSTTPSSHT LELVALDSEV LRDSLQCQDH
110 120 130 140 150
LSPGVSSLCD DDPGSNKPLS SNLRRLLEAG SLKLDAAATA NGRVESPVNV
160 170 180 190 200
GSNLSFSPPS HHAQQLSVLA RKLAEKQEQN DQYTPSNRFI WNQGKWLPNS
210 220 230 240 250
TTTCSLSPDS AILKLKAAAN AVLQDKSLTR TEETMRFESF SSPFSSQSAS
260 270 280 290 300
STLAALSKKV SERSLTPGQE HPPPASSFLS LASMTSSAAL LKEVAARAAG
310 320 330 340 350
SLLAEKSSLL PEDPLPPPPS EKKPEKVTPP PPPPPPPPPP PPPQSLELLL
360 370 380 390 400
LPVPKGRVSK PSNSASEEES GKPFQCPICG LVIKRKSYWK RHMVIHTGLK
410 420 430 440 450
SHQCPLCPFR CARKDNLKSH MKVHQHQDRG ETFQCQLCPF TSSRHFSLKL
460 470 480 490 500
HMRCHQHFLR TEAKVKEEIP DPDVKGSPHL SDSACLGQQR EGGGTELVGT
510 520 530 540 550
MMTSNTPERT SQGGAGVSPL LVKEEPKEDN GLPTSFTLNA ADRPANHTKL
560 570 580 590 600
KDPSEYVANS ASALFSQDIS VKMASDFLMK LSAANQKEPM NLNFKVKEEP
610 620 630 640 650
KEGESLSTTL PRSSYVFSPE SEVSAPGVSE DALKPQEGKG SVLRRDVSVK
660 670 680 690 700
AASELLMKLS AESYKETQMV KIKEEPMEVD IQDSHVSISP SRNVGYSTLI
710 720 730 740 750
GREKTEPLQK MPEGRVPPER NLFSQDISVK MASELLFQLS EKVSKEHNHT
760 770 780 790 800
KENTIRTTTS PFFSEDTFRQ SPFTSNSKEL LPSDSVLHGR ISAPETEKIV
810 820 830 840 850
LEAGNGLPSW KFNDQLFPCD VCGKVFGRQQ TLSRHLSLHT EERKYKCHLC
860 870 880 890 900
PYAAKCRANL NQHLTVHSVK LVSTDTEDIV SAVTSEGSDG KKHPYYYSCH
910 920 930 940 950
VCGFETELNV QFVSHMSLHV DKEQWMFSIC CTACDFVTME EAEIKTHIGT
960 970 980 990 1000
KHTGEDRKTP SESNSPSSSS LSALSDSANS KDDSDGSQKN KGGNNLLVIS
1010 1020 1030 1040 1050
VMPGSQPSLN SEEKPEKGFE CVFCNFVCKT KNMFERHLQI HLITRMFECD
1060 1070 1080
VCHKFMKTPE QLLEHKKCHT VPTGGLNSGQ W
Length:1,081
Mass (Da):119,165
Last modified:July 25, 2006 - v1
Checksum:iBA32DF19FE700EFA
GO
Isoform 2 (identifier: Q17R98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1077-1077: N → K
     1078-1081: Missing.

Note: No experimental confirmation available.
Show »
Length:1,077
Mass (Da):118,721
Checksum:i09000EFA9DDC74CE
GO
Isoform 3 (identifier: Q17R98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-365: Missing.

Note: No experimental confirmation available.
Show »
Length:731
Mass (Da):81,863
Checksum:iB3958BAE22BADCE3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151H → P in AAP97679 (Ref. 1) Curated
Sequence conflicti39 – 391T → A in BAC03591 (PubMed:14702039).Curated
Sequence conflicti164 – 1641Q → R in BAC03591 (PubMed:14702039).Curated
Sequence conflicti240 – 2401F → L in BAC03591 (PubMed:14702039).Curated
Sequence conflicti859 – 8591N → D in AAP97679 (Ref. 1) Curated
Sequence conflicti905 – 9051E → G in BAC03591 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 365350Missing in isoform 3. 1 PublicationVSP_032463Add
BLAST
Alternative sequencei1077 – 10771N → K in isoform 2. 1 PublicationVSP_032464
Alternative sequencei1078 – 10814Missing in isoform 2. 1 PublicationVSP_032465

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450485 mRNA. Translation: AAP97679.1.
AK091130 mRNA. Translation: BAC03591.1.
BC117407 mRNA. Translation: AAI17408.1.
BC143577 mRNA. Translation: AAI43578.1.
CCDSiCCDS34072.1. [Q17R98-2]
CCDS77968.1. [Q17R98-1]
RefSeqiNP_001293144.1. NM_001306215.1. [Q17R98-1]
NP_849157.2. NM_178835.4. [Q17R98-2]
UniGeneiHs.133916.
Hs.633543.

Genome annotation databases

EnsembliENST00000379448; ENSP00000368761; ENSG00000151612. [Q17R98-2]
ENST00000508784; ENSP00000421863; ENSG00000151612. [Q17R98-1]
GeneIDi152485.
KEGGihsa:152485.
UCSCiuc003ikm.4. human. [Q17R98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450485 mRNA. Translation: AAP97679.1.
AK091130 mRNA. Translation: BAC03591.1.
BC117407 mRNA. Translation: AAI17408.1.
BC143577 mRNA. Translation: AAI43578.1.
CCDSiCCDS34072.1. [Q17R98-2]
CCDS77968.1. [Q17R98-1]
RefSeqiNP_001293144.1. NM_001306215.1. [Q17R98-1]
NP_849157.2. NM_178835.4. [Q17R98-2]
UniGeneiHs.133916.
Hs.633543.

3D structure databases

ProteinModelPortaliQ17R98.
SMRiQ17R98. Positions 365-456, 819-868, 897-960, 1005-1071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127447. 7 interactions.
DIPiDIP-61048N.
IntActiQ17R98. 2 interactions.
STRINGi9606.ENSP00000368761.

PTM databases

iPTMnetiQ17R98.
PhosphoSiteiQ17R98.
SwissPalmiQ17R98.

Polymorphism and mutation databases

BioMutaiZNF827.
DMDMi121945543.

Proteomic databases

MaxQBiQ17R98.
PaxDbiQ17R98.
PeptideAtlasiQ17R98.
PRIDEiQ17R98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379448; ENSP00000368761; ENSG00000151612. [Q17R98-2]
ENST00000508784; ENSP00000421863; ENSG00000151612. [Q17R98-1]
GeneIDi152485.
KEGGihsa:152485.
UCSCiuc003ikm.4. human. [Q17R98-1]

Organism-specific databases

CTDi152485.
GeneCardsiZNF827.
HGNCiHGNC:27193. ZNF827.
HPAiHPA021166.
HPA057275.
neXtProtiNX_Q17R98.
PharmGKBiPA162410714.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125544.
HOGENOMiHOG000082483.
HOVERGENiHBG066774.
InParanoidiQ17R98.
OrthoDBiEOG091G01DQ.
PhylomeDBiQ17R98.
TreeFamiTF333046.

Miscellaneous databases

ChiTaRSiZNF827. human.
GenomeRNAii152485.
PROiQ17R98.

Gene expression databases

BgeeiENSG00000151612.
CleanExiHS_ZNF827.
ExpressionAtlasiQ17R98. baseline and differential.
GenevisibleiQ17R98. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN827_HUMAN
AccessioniPrimary (citable) accession number: Q17R98
Secondary accession number(s): B7ZL52, Q7Z4S7, Q8N279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.